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Pharmceutical Intermediate 2-Aminopyrimidine CAS:109-12-6 Best Quality and Sample Available

Name: Pharmceutical Intermediate 2-Aminopyrimidine CAS:109-12-6 Best Quality and Sample Available
Brand: HyperChem
SKU: pr2503241369
Price: 125 USD
Availability: InStock

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CAS No.:

109-12-6

Grade:

Pharmaceutical Grade

Content:

99.9%

Port:

Hangzhou

Brand:

HyperChem

Packaging:

1kg/Bag or other quantities

Price valid (until):

2025-04-24

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	2-Aminopyrimidine
CAS number	109-12-6
Synonym	SPYRIMIDIN-2-AMINE; PYRIMIDIN-2-YLAMINE;
Related APIs #	5-Aminopyrimidine 4-Aminopyrimidine 2-Amino-4-methylpyrimidine 2-Amino-5-bromopyrimidine 2-Amino-4,6-dichloropyrimidine
Description	Description: 2-Aminopyrimidine (CAS 109-12-6) is a heterocyclic organic compound with the molecular formula C₄H₅N₃ and a molecular weight of 95.10 g/mol. It is a pyrimidine derivative characterized by a six-membered aromatic ring containing two nitrogen atoms at positions 1 and 3, with an amino group (-NH₂) substituted at position 2. The compound exists as a white to off-white crystalline solid at room temperature, with a melting point of 85–88°C and a boiling point of 267°C. It is sparingly soluble in water but dissolves readily in polar organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). As a versatile building block in organic synthesis, 2-aminopyrimidine is widely utilized in pharmaceutical, agrochemical, and material science industries. Its structural similarity to nucleic acid bases (e.g., cytosine and thymine) makes it a critical scaffold for designing bioactive molecules. The compound is commercially available in high purity grades (>98%) and is typically supplied in sealed containers under inert gas to prevent degradation. 2. Applications and Use Cases 2.1 Pharmaceutical Industry 2-Aminopyrimidine is a key intermediate in synthesizing kinase inhibitors, antiviral agents, and anticancer drugs. For example: Imatinib, a tyrosine kinase inhibitor for chronic myeloid leukemia, incorporates a pyrimidine backbone derived from 2-aminopyrimidine. Baricitinib, a JAK inhibitor for rheumatoid arthritis, utilizes 2-aminopyrimidine as a core structure. Antimicrobial agents such as trimethoprim rely on pyrimidine derivatives to inhibit bacterial dihydrofolate reductase. 2.2 Agrochemicals The compound is used to develop herbicides and fungicides. Its ability to disrupt enzymatic pathways in plants and pests makes it valuable for crop protection. 2.3 Material Science In coordination chemistry, 2-aminopyrimidine acts as a ligand for metal complexes, enabling applications in catalysis and luminescent materials. 3. Biological Mechanisms 3.1 Role in Kinase Inhibition 2-Aminopyrimidine derivatives are renowned for their ability to inhibit protein kinases, enzymes critical for signal transduction in cellular processes. The amino group at position 2 enhances hydrogen bonding with kinase ATP-binding pockets, enabling competitive inhibition. For instance: EGFR (Epidermal Growth Factor Receptor) inhibitors like gefitinib utilize pyrimidine scaffolds to block aberrant signaling in cancer cells. CDK (Cyclin-Dependent Kinase) inhibitors arrest the cell cycle by binding to CDK-ATP sites. 3.2 Antifolate Activity In antimicrobial and anticancer contexts, 2-aminopyrimidine derivatives interfere with dihydrofolate reductase (DHFR), an enzyme essential for nucleotide synthesis. By mimicking dihydrofolate, these compounds deplete tetrahydrofolate pools, halting DNA replication in pathogens or rapidly dividing cancer cells. 3.3 Antiviral Action Pyrimidine analogs, including 2-aminopyrimidine derivatives, inhibit viral polymerases or integrases. For example, HIV reverse transcriptase inhibitors incorporate modified pyrimidines to terminate viral DNA elongation. 4. Usage Guidelines 4.1 Handling and Storage Storage: Store in a cool (<25°C), dry place under inert gas (argon or nitrogen) to prevent oxidation. Protect from light and moisture. Handling: Use personal protective equipment (PPE), including gloves, lab coats, and safety goggles. Avoid inhalation or skin contact. 4.2 Solubility and Formulation For biological assays, dissolve 2-aminopyrimidine in DMSO (up to 50 mg/mL) and dilute in aqueous buffers. Note that prolonged storage in DMSO may degrade the compound. In synthetic chemistry, reactions often employ anhydrous solvents (e.g., THF, dichloromethane) under nitrogen atmosphere to enhance stability. 4.3 Safety Data GHS Hazard Statements: H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation). First Aid: Rinse skin/eyes with water for 15 minutes if exposed. Seek medical attention for ingestion or inhalation. 5. Synthetic Routes 2-Aminopyrimidine is synthesized via: Condensation Reactions: Heating malononitrile with guanidine derivatives in acidic or basic conditions. Modified Pinner Synthesis: Reacting amidines with β-ketoesters or β-diketones. Catalytic Amination: Transition metal-catalyzed amination of halopyrimidines using ammonia or amines. 6. Research and Development Trends Recent studies focus on: PROTACs (Proteolysis-Targeting Chimeras): Incorporating 2-aminopyrimidine to degrade disease-causing proteins. Covalent Inhibitors: Designing pyrimidine-based electrophiles (e.g., acrylamides) for irreversible kinase binding. AI-Driven Drug Discovery: Screening 2-aminopyrimidine libraries via machine learning to optimize pharmacokinetic properties. 7. Regulatory and Environmental Considerations REACH Compliance: 2-Aminopyrimidine is registered under EU REACH for industrial use. Ecotoxicity: Limited data suggest moderate toxicity to aquatic organisms (EC₅₀ ~10 mg/L for algae). Proper waste disposal via incineration is recommended. 8. Conclusion 2-Aminopyrimidine is a cornerstone of modern medicinal chemistry, offering unparalleled versatility in drug design and industrial applications. Its unique pharmacophoric features and tunable reactivity ensure its continued prominence in scientific and commercial endeavors. Researchers and manufacturers must adhere to safety protocols while leveraging its potential to address unmet medical and technological challenges.
Molecular Formula	C₄H₅N₃
Molecular Weight	95.1 g/mol
Appearance	White or almost white powder
Quality Standard	Enterprise standard; 98%- 102%(ICP-AES)
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0-28℃ for short term (days to weeks) or -5-8 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Double plastic bags inside, fiber drum outside, any quantity available.
Commercial package	Aluminium Tin, Fiber drum
Origin	China

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FAQ

Q1. What is the Hyper chem payment term?
T/T advance
LC at sight
DP at sight
Trade assurance
Money gram

Q2. What is Hyper chem shipment policy?
Our policy is to strive for the quickest shipment time possible, with ready stock sample shipment typically going out the same day that your order was placed. Your satisfaction is very important to us.
For non-ready stock, please contact the Hyper Chem sales team to negotiate.

Q3. What hyper chem will provide after shipment?
For sample orders:
After shipment is done, an timely email including:

Track details (Fedex /TNT/DHL/EMS Track number)

Package photo

COA, MSDS, etc

Dispatch date & Estimated arriving time

Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided
in scan-copy and original, to help customers complete the customs clearance process.

Q4. What is Hyper Chem shipment term?

By Express
DHL  FedEx  TNT  EMS
Fast:5 days around
High cost, door to door service

By Air
Suitable for more than 50kg
Fast :3-7 days Hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Slow:7-45 days, Low cost, port to port, professional broker needed
We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. Does hyper chem provide a shipment return policy?
Yes, we have.
Return Policy: At Hyper chem, your satisfaction is guaranteed. If you are dissatisfied for any reason with a product, please send back the unused portion along with your packing slip and a brief note on why you were dissatisfied within 45 days of purchase for a full refund to:

Q6. What is hyper chem After-sales service
•Documents support: COA ,MSDS, MOA ,MS Report,HNMR Report,SDS,DMF
• Customer Support: Shipment clearance support, quality issue support
• Automated Customer Service: Our worldwide customers enjoy immediate 24/7 access to the HYPER CHEM support team from any location, at any time.

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

Certificates

Basic Info

Product Name:

2-Aminopyrimidine

Other Name:

2-Pyrimidinamine;Pyrimidine,2-amino-;Pyrimidine,1,2-dihydro-2-imino-;2-Aminopyrimidine;1,2-Dihydro-2-iminopyrimidine;2-Pyrimidylamine;Pyrimidin-2-ylamine;NSC 1912;6918-31-6

CAS No.:

109-12-6

Molecular Formula:

C4H5N3

InChIKeys:

InChIKey=LJXQPZWIHJMPQQ-UHFFFAOYSA-N

Molecular Weight:

95.1

Exact Mass:

95.10

BRN:

107014

EC Number:

203-648-4

UNII:

OB8I17P2G4

NSC Number:

1912

HScode:

29335995

Categories:

Food Antioxidants

Characteristics

PSA:

51.8

XLogP3:

-0.2

Appearance:

White to light yellow Powder

Density:

1.1031 (rough estimate)

Melting Point:

127.5 °C

Boiling Point:

157 °C @ Press: 135 Torr

Flash Point:

103 °C

Refractive Index:

1.5200 (estimate)

Water Solubility:

SOLUBLE

Storage Conditions:

-20°C

Vapor Pressure:

0.00521mmHg at 25°C

See More 2-Aminopyrimidine Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 2-Aminopyrimidine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
Thailand	2-(diethylamino)-6-methyl-1H-pyrimidin-4-one	1 MT	Mar 25, 2025
Thailand	2-Aminopyrimidine	1 KG	Mar 24, 2025
Thailand	2-Aminopyrimidine	1 MT	Mar 24, 2025

Post an enquiry for this product

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Pharmceutical Intermediate 2-Aminopyrimidine CAS:109-12-6 Best Quality and Sample Available

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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