USA/AU/EU warehouse supply raw powder Montelukast CAS 158966-92-8 and good price Montelukast
2 Inquiries
158966-92-8
Pharmaceutical Grade
99%
guangdong
1kg/bag;25kg/Cardboard Drum
2025-05-14
Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceSolid
Solid
Montelukast is a member of quinolines, a monocarboxylic acid and an aliphatic sulfide. It has a role as a leukotriene antagonist, an anti-asthmatic drug and an anti-arrhythmia drug. It is a conjugate acid of a montelukast(1-).|Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs. Although capable of demonstrating effectiveness, the use of such LTRAs like montelukast is typically in addition to or complementary with the use of inhaled corticosteroids or other agents in asthma step therapy. Regardless, in 2008-2009, there were FDA-led investigations into the possibility of montelukast to elicit neuropsychiatric effects like agitation, hallucinations, suicidal behaviour, and others in individuals who used the medication. And although these kinds of effects are currently included in the official prescribing information for montelukast, the drug still sees extensive use worldwide via millions of prescriptions annually and has since become available as a generic and as a brand name product.|Montelukast is a Leukotriene Receptor Antagonist. The mechanism of action of montelukast is as a Leukotriene Receptor Antagonist.|Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury.|Montelukast is a selective cysteinyl leukotriene receptor antagonist with anti-inflammatory and bronchodilating activities. Upon administration, montelukast selectively and competitively blocks the cysteinyl leukotriene 1 (CysLT1) receptor, preventing binding of the inflammatory mediator leukotriene D4 (LTD4). Inhibition of LTD4 activity results in inhibition of leukotriene-mediated inflammatory events including migration of eosinophils and neutrophils, adhesion of leukocytes to vascular endothelium, monocyte and neutrophil aggregation, increased airway edema, increased capillary permeability, and bronchoconstriction. The CysLT1 receptor is found in a number of tissues including spleen, lung, placenta, small intestine, and nasal mucosa, and in a variety of cell types including monocyte/macrophages, mast cells, eosinophils, CD34-positive hemopoietic progenitor cells, neutrophils and endothelial cells.Basic Info-
Product Name:
Montelukast
Other Name:Cyclopropaneacetic acid,1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-;Cyclopropaneacetic acid,1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-,[R-(E)]-;1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid;Montelukast;2-[1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropyl]acetic acid;1-[[[(R)-1-[3-[(E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid;[1-[[[(1R)-1-[3-[(E)-2-(7-Chloroquinolin-2-yl)vinyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetic acid;(R,E)-1-[[[1-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid;Velukast
CAS No.:158966-92-8
Molecular Formula:C35H36ClNO3S
InChIKeys:InChIKey=UCHDWCPVSPXUMX-TZIWLTJVSA-N
Molecular Weight:586.18
Exact Mass:586.18
EC Number:605-168-4
UNII:MHM278SD3E
DSSTox ID:DTXSID9023334
NCI Thesaurus Code:C66189
ATC Code:R03DC03|R - Respiratory system
Categories:
Characteristics-
PSA:
95.7
XLogP3:7.9
Appearance:Solid
Density:1.272±0.06 g/cm3(Predicted)
Melting Point:145-148 °C @ Solvent: Toluene, Methanol
Boiling Point:750.5±60.0 °C(Predicted)
Flash Point:407.7±32.9 °C
Refractive Index:1.678
Water Solubility:8.20e-06 g/L
Storage Conditions:Commercially available montelukast sodium film-coated and chewable tablets and oral granules should be stored at 25 deg C and protected from light and moisture with exposure for short periods to temperatures of 15-30 deg C permitted. When stored as directed, montelukast sodium film-coated and chewable tablets have an expiration date of 2 years after the date of manufacture.
Vapor Pressure:4.14X10-21 mm Hg at 25 deg C (est)
Henrys Law Constant:Henry's Law constant = 1.42X10-20 atm-cu m/mole at 25 °C (est)
Collision Cross Section:243 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]
Experimental Properties:Hydroxyl radical reaction rate constant = 1.06X10-14 cu cm/molec-sec at 25 °C (est) /cis isomer/|Hydroxyl radical reaction rate constant = 1.14X10-14 cu cm/molec-sec at 25 °C (est) /trans isomer/|Ozone reaction rate constant = 1.3X10-18 cu cm/molec-sec at 25 °C (est) /cis isomer/|Ozone reaction rate constant = 2.5X10-18 cu cm/molec-sec at 25 °C (est) /trans isomer/
Hazard IdentificationClassification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
Pictogram(s) No symbol. Signal word No signal word
Hazard statement(s) none
Precautionary statement(s) Prevention none
Response none
Storage none
Disposal none
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10
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Location:
XINYUAN DADUHUI PHASE 1, NO.258 TAOYUAN NORTH ROAD, LIANHU DISTRICT, XI 'AN , SHAANXI CHINA
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Payment Terms:
TT against copy of documents,100% TT in advance
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Average lead Time:
30
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2023
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
Pakistan
Montilukast
2 KG Feb 10, 2025 
Bangladesh
Montelukast
1 MT Jul 15, 2024 Post an enquiry for this product
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