Made In China Amlodipine

Amlodipine
Basic Introduction
amlodipine, chemically known as 6-methyl-2 -(2-aminoethoxy) methyl-4 -(2-chlorobenzyl)-1, 4-dihydro3, 5- pyr diformate, with the molecular formula C20H25ClN2O5, is a drug used to treat hypertension and coronary artery disease.

Basic information
Chinese name: Amlodipine

English name: amlodipine
CAS Number: 88150-42-9
Molecular formula: C20H25ClN2O5
Molecular weight: 408.879
Precise mass: 408.14500
PSA: 99.88000
LogP: 4.16

Physical and chemical properties
Density: 1.227 g/cm ³
Melting point: 178-179 ° C
Boiling point: 527.2 ° C
Flash point: 272.6℃
Refractive index: 1.546
Appearance and properties: Yellow solid
Water solubility: 75.3 mg/L [2]

The pharmacological effects of amlodipine
1. Dilate peripheral small arteries to reduce peripheral resistance (afterload), thereby decreasing myocardial energy consumption and oxygen demand;
2. Dilate the coronary arteries and small coronary arteries in both normal and ischemic areas to increase myocardial oxygen supply to patients with coronary spasm (variant angina pectoris).

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