Factory supply Helicid Best Quality CAS 80154-34-3

I. Overview

1. Chemical Properties and Sources
   • Chemical Structure: Helicid (also known as 4-(β-D-Allopyranosyloxy)-benzaldehyde) is a monomeric glycoside with the molecular formula C₁₃H₁₆O₇ (molecular weight: 284.26; CAS No.: 80154-34-3). It appears as a white to faint yellow crystalline powder in needle, rod, or flake forms, odorless, with a slightly bitter taste.
   • Solubility: Freely soluble in hot water, sparingly soluble in cold water, ethanol, or methanol, and insoluble in ether or chloroform.
   • Stability: Melting point: 195–199°C; specific optical rotation: -105° to -110°. Requires storage in airtight, dry conditions.
   • Natural Sources: Extracted from the fruits of Helicia nilgirica Bedd (Proteaceae family), a plant native to Yunnan, China. Structurally similar to gastrodin (a major active component of Gastrodia elata).
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2. Pharmacological Actions
   • CNS Regulation: Modulates the balance between cortical excitation and inhibition, exerting sedative, hypnotic, and analgesic effects. Its sedative, hypnotic, and analgesic efficacy surpasses gastrodin, with rapid onset (typically effective within 3–7 days).
   • Antidepressant Effects: Animal studies demonstrate that Helicid alleviates depressive-like behaviors in rats induced by chronic unpredictable mild stress (CUMS).
   • Safety Profile:
     • Acute Toxicity: No abnormalities observed in mice at intravenous doses of 1500 mg/kg.
     • Subchronic Toxicity: Rats administered 300 mg/kg/day for 15 days showed no significant changes in hematology, blood chemistry, or major organ pathology.
     • Developmental Safety: High-dose Helicid exposure during pregnancy did not impair early physical or central nervous system development in offspring rats.

II. Applications

1. Clinical Uses
   • Neurosis and Psychosomatic Disorders: Effective for treating headaches, dizziness, and sleep disturbances caused by neurosis, with rapid efficacy and high safety.
   • Primary Headache Disorders: Provides symptomatic relief for primary headaches.
   • Adjuvant Therapy: Improves sleep quality, particularly for insomnia associated with pain or neurasthenia.
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2. Pharmaceutical Formulations
   • Dispersible Tablets: Characterized by rapid disintegration, excellent dispersibility, and accelerated drug dissolution/absorption, enhancing bioavailability. Suitable for oral administration (swallowed whole or dispersed in water), ideal for elderly, pediatric, or dysphagic patients.
   • Conventional Tablets: Also used clinically, though dispersible tablets offer superior efficacy and patient compliance.
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3. Research Applications
   • Neuroscience Research: Employed in studies of psychoneurosis to investigate mechanisms underlying sedation, sleep promotion, and analgesia.
   • Pharmacological Experiments: Utilized as a research tool to evaluate the efficacy and safety of CNS-active drugs.
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4. Advantages and Characteristics
   • Natural and Low-Toxicity: A safer alternative to synthetic sedative-hypnotics due to its natural origin and low toxicity.
   • Non-Addictive: Suitable for long-term use without risk of dependence.
   • Mild and Sustained Effects: Rapid symptom relief combined with prolonged therapeutic duration.