High Quality White Powder Nicotinamide Vitamin B3 CAS 98-92-0 Food Grade Cosmetic Grade

Nicotinamide More Info

Nicotinamide, also known as niacinamide or 3-pyridinecarboxamide (CAS 98-92-0), is a water-soluble form of vitamin B3 and an essential nutrient with broad biological and medical significance. It is an amide derivative of nicotinic acid and a key component of the vitamin B complex family.

Biological Role and Biochemistry

Nicotinamide is a precursor to the coenzymes nicotinamide adenine dinucleotide (NAD⁺) and nicotinamide adenine dinucleotide phosphate (NADP⁺), which are crucial for cellular metabolism. These cofactors participate in numerous enzymatic oxidation-reduction (redox) reactions such as glycolysis, the citric acid cycle, and the electron transport chain, facilitating energy production in the form of ATP.
NAD⁺ accepts hydride ions (H⁻) during metabolic reactions, becoming NADH, a high-energy molecule that donates electrons in the electron transport chain.
NADP⁺ and NADPH are involved in anabolic reactions and oxidative stress responses.
Nicotinamide is recycled in cells via the salvage pathway, maintaining NAD⁺ levels.
Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in NAD biosynthesis, regulating cellular metabolism, aging, inflammation, and stress responses through NAD-dependent enzymes like sirtuins and PARPs.

Medical Uses

Niacin deficiency (Pellagra): Nicotinamide is the preferred treatment for pellagra, preventing and curing this condition caused by vitamin B3 deficiency.
Acne: Topical nicotinamide creams (typically 2–4%) reduce inflammation, sebum production, and bacterial activation (Cutibacterium acnes), improving acne and inflammatory skin conditions.
Skin cancer prevention: Oral nicotinamide at doses of 500–1000 mg daily decreases the risk of non-melanoma skin cancers in high-risk individuals by enhancing DNA repair and preventing UV-induced immune suppression.
Cosmetic use: Nicotinamide improves skin barrier function by increasing ceramide biosynthesis and reduces hyperpigmentation and wrinkles.
Other potential uses: Investigated for diabetes prevention, neuroprotection, and anti-inflammatory effects.

Dietary Sources and Supplementation

Found naturally in yeast, meat, milk, green vegetables, and fortified grains.
Available over the counter as a generic supplement and included in multivitamins.
Commercially produced for use in food fortification and pharmaceuticals.

Safety and Side Effects

Side effects are minimal at normal doses.
At very high doses (>3 g/day), reversible liver toxicity has been reported, including elevated liver enzymes and rare cases of hepatotoxicity.
Nicotinamide is safe during pregnancy at recommended doses.
It does not cause flushing, unlike nicotinic acid.
No evidence of teratogenicity or oncogenicity in humans, though high doses may potentiate tumor formation in animal models under certain conditions.
Minor insulin resistance has been observed in some studies but is inconsistent.

Pharmacology and Mechanism of Action

Nicotinamide functions primarily as a vitamin and coenzyme precursor, facilitating energy metabolism and DNA repair. It modulates cellular stress responses by influencing NAD-dependent enzymes, including sirtuins, which regulate aging and inflammation. Nicotinamide can also be methylated in the liver to 1-methylnicotinamide, which has biological activity.

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Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

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HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.