Food Grade JP/USP/In-house Standard Mecobalamin CAS 13422-55-4 Methylcobalamin Vitamin B12

Mecobalamin More Info

Mecobalamin (also known as methylcobalamin) is an active, coenzyme form of vitamin B12 used primarily to treat vitamin B12 deficiency-related conditions such as peripheral neuropathy and megaloblastic anemia.

Mechanism of Action

Mecobalamin acts as a cofactor for key enzymatic reactions in the body:
It serves as a coenzyme for methionine synthase, which catalyzes the conversion of homocysteine to methionine. This reaction is critical for DNA synthesis because it regenerates tetrahydrofolate from 5-methyltetrahydrofolate, supporting purine and pyrimidine synthesis needed for red blood cell production and neurological function.
Mecobalamin also acts as a cofactor for L-methylmalonyl-CoA mutase, converting L-methylmalonyl-CoA to succinyl-CoA, a step important in the metabolism of certain fatty acids and amino acids.
By facilitating these reactions, mecobalamin helps maintain myelin sheath integrity around nerve fibers, promoting nerve regeneration and protecting against neuronal damage.
Unlike cyanocobalamin, mecobalamin can cross the blood-brain barrier without conversion, directly supporting central nervous system function and neurotransmitter synthesis such as serotonin, which influences mood and cognitive function.

Applications

Treatment of peripheral neuropathies caused by vitamin B12 deficiency, diabetes, or other neurological disorders.
Management of megaloblastic anemia due to vitamin B12 deficiency.
Supportive therapy in conditions involving nerve damage or degeneration.
Sometimes used in high doses experimentally for neurodegenerative diseases like amyotrophic lateral sclerosis (ALS).

Routes of Administration and Dosage

Parenteral (intramuscular or subcutaneous) injection: Commonly used for rapid correction of deficiency and neurological symptoms.
Oral supplementation: Available but requires adequate intrinsic factor and intestinal absorption; high doses may be needed.
Other forms: Sublingual or nasal formulations exist but are less common.

Safety and Side Effects

Generally well tolerated.
Common side effects may include injection site pain, nausea, vomiting, diarrhea, headache, and mild gastrointestinal upset.
Rare allergic reactions or anaphylaxis can occur, especially with injectable forms.
Caution advised in patients with known hypersensitivity to vitamin B12 compounds.
Interactions may occur with certain antibiotics (e.g., chloramphenicol), anticancer agents, and anti-mycobacterial drugs.

Pharmacokinetics

Mecobalamin is absorbed in the intestine with the help of intrinsic factor or via passive diffusion at high doses.
In systemic circulation, it binds to transcobalamin II, which transports it into cells.
It is metabolized intracellularly and participates directly in enzymatic reactions.
Has a relatively short half-life but is retained in tissues as active coenzyme.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

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For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

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Q5. What HyperChem will provide after shipment?

For sample orders: 
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For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

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HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.