High quality Ezetimibe 99%

Ezetimibe is a lipid-lowering medication primarily used to manage hypercholesterolemia by selectively inhibiting intestinal cholesterol absorption.

Mechanism of Action

Ezetimibe works by targeting the Niemann-Pick C1-Like 1 (NPC1L1) sterol transporter located at the brush border of the small intestine. It inhibits the interaction between the NPC1L1/cholesterol complex and the clathrin/AP2 endocytic machinery, thereby preventing the endocytosis and uptake of cholesterol into enterocytes. This leads to reduced intestinal absorption of dietary and biliary cholesterol without affecting the absorption of fat-soluble vitamins or triglycerides.
The reduced cholesterol absorption decreases the delivery of cholesterol to the liver, which in turn increases hepatic clearance of cholesterol from the blood, lowering plasma levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apo B), and non-high-density lipoprotein cholesterol (non-HDL-C). Ezetimibe typically lowers LDL-C by 13% to 20% when used as monotherapy and has additive effects when combined with statins or fenofibrate.

Applications

Primary hyperlipidemia (high cholesterol)
Mixed hyperlipidemia
Homozygous familial hypercholesterolemia (HoFH)
Homozygous sitosterolemia (phytosterolemia)
Adjunct therapy with statins or fenofibrate to enhance cholesterol lowering
Used in fixed-dose combinations with statins such as simvastatin or rosuvastatin for enhanced effect.

Routes of Administration and Dosage

Route: Oral tablets
Dose: Usually 10 mg once daily
Can be taken with or without food; food does not significantly affect the extent of absorption, though high-fat meals can increase peak plasma concentration by about 38%.
When combined with bile acid sequestrants, ezetimibe should be taken at least 2 hours before or 4 hours after the sequestrant to avoid interference with absorption.

Our company, Jianyan E-commerce Trading House in Yiwu City, is an innovative company mainly engaged in the research and development, production and sales of pharmaceutical intermediates and fine chemicals. The products are mainly used in the fields of medicine, health products, cosmetics, pesticides and electronic chemistry.
  We have a research and development centre and a production base. The R&D centre has advanced organic synthesis and analytical testing equipment. At the production base, we have large reaction vessels, including various specifications of stainless steel reaction vessels and enamel reaction vessels, capable of high-pressure,high-temperature and low-temperature reactions, with production capacities ranging from kilograms to tonnes. The company has established a comprehensive marketing network and its products are exported to countries and regions such as the United States, South Korea, Japan, India and Europe.

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1. Own your own chemical plant
2. Rich professional production experience
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4. Price, quality and service, we care about all your concerns
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7. Dedicated researchers customize it for you.
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FAQ
1. I did not find what I was looking for. Do you provide specific pack sizes or different packaging?

We are all about finding or creating the right solution for you. Our team is ready to work with you to meet your specific needs, even for small quantities. Please contact us.

2. Can I buy samples?

Please feel free to contact us.

3.What is your lead time?

It depends on the proudct and order quantity. Please contact us.

4. How can I get a price?

After we get your inquiry, we usually quote within 24 hours.

5. How to confirm the quality before placing the order？

You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.

7. Do you provide COA?

Yes. We'll provide certificate of analysis before shipment