 Home > Active Pharmaceutical Ingredients > Circulatory System Drugs > Candesartan for Sale > Candesartan 139481-59-7

Candesartan 139481-59-7

1 Inquiries

Unit Price: Get Latest Price 

CAS No.:

139481-59-7

Port:

shanghai

Packaging:

25kg/drum

Sample Available:

Yes

Price valid (until):

2025-06-27

Contact Supplier

 Chat Now

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

Company Type:

Manufactory

Location:

China

Payment Terms:

TT against copy of documents,L/C

Average Lead Time:

7 days

Qualification:

Main Products:

D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP

 Visit Store

Product Description
Seller Information
Inquiry History

Description

Product Detail

Candesartan is an angiotensin II receptor antagonist with an IC50 of 0.26 nM.It is an angiotensin II receptor antagonist

Items	Specifications

ECHEMI Editorial Reference

Crystalline SolidChEBI: A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin eceptor antagonist used for the treatment of hypertension.Candesartan, (+)-1-[[(cyclohexyloxy)carbonyl]-oxy]ethyl 2- ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate(Atacand), like losartan, possesses the acidic
Solid
Candesartan is a benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension. It has a role as an antihypertensive agent, an angiotensin receptor antagonist, an environmental contaminant and a xenobiotic. It is a benzimidazolecarboxylic acid and a biphenylyltetrazole. It is a conjugate acid of a candesartan(2-).|Candesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. It is available as a prodrug in the form of [candesartan cilexetil].|Candesartan is an Angiotensin 2 Receptor Blocker. The mechanism of action of candesartan is as an Angiotensin 2 Receptor Antagonist.|Candesartan is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure. Candesartan is associated with a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury.|Candesartan is a synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with antihypertensive activity. Candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 (AT1) in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of AT1 in the adrenal gland inhibits angiotensin II-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure.

Basic Info

Product Name:

Candesartan

Other Name:

1H-Benzimidazole-7-carboxylic acid,2-ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-;1H-Benzimidazole-7-carboxylic acid,2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-;2-Ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid;CV 11974;Candesartan;Candesartan M1;2-Ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid;2-Ethoxy-1-[[2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-7-benzimidazolecarboxylic acid;2-Ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid;3-[[2′-(1H-Tetrazol-5-yl)biphenyl-4-yl]methyl]-2-ethoxy-3H-benzimidazole-4-carboxylic acid;1-((2′-(1H-Tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid;2-Ethoxy-1-([4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl)-1H-1,3-benzodiazole-7-carboxylic acid;875515-04-1

CAS No.:

139481-59-7

Molecular Formula:

C24H20N6O3

InChIKeys:

InChIKey=HTQMVQVXFRQIKW-UHFFFAOYSA-N

Molecular Weight:

440.45

Exact Mass:

440.45

EC Number:

1806241-263-5

UNII:

S8Q36MD2XX

NSC Number:

759858

DSSTox ID:

DTXSID0022725

NCI Thesaurus Code:

C65284

Color/Form:

Colorless crystals from ethyl acetate + methanol

ATC Code:

C - Cardiovascular system

HScode:

29419000

Categories:

Circulatory System Drugs

Characteristics

PSA:

119

XLogP3:

4.1

Appearance:

Solid

Density:

1.41±0.1 g/cm3(Predicted)

Melting Point:

183-185 °C

Boiling Point:

754.8±70.0 °C(Predicted)

Flash Point:

410.3±35.7 °C

Refractive Index:

1.719

Water Solubility:

soluble in ethyl acetate, methanol, water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).

Storage Conditions:

-20°C Freezer

Vapor Pressure:

1.8X10-18 mm Hg at 25 deg C (est)

Henrys Law Constant:

Henry's Law constant = 8.7X10-19 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pKa1 = 2.45 (carboxylic acid); pKa2 = 6.70 (N-heterocyclic) (est)

Experimental Properties:

Colorless crystals from ethanol + water, mp 163 °C (decomposes). Also reported as white to off-white powder, sparingly soluble in methanol. Practically insoluble in water. /Candesartan 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl ester/|White to off-white powder, mw - 610.67. Practically insoluble in water and sparingly soluble in methanol. ... a racemic mixture containing one chiral center at the cyclohexyloxycarbonyloxy ethyl ester group. Following oral administration ... undergoes hydrolysis at the ester link to form the active drug, candesartan, which is achiral. /Cilexetil/|White, or practically white, crystalline powder, mw - 297.72 .. Slightly soluble in water, but freely soluble in hydroxide solution /Cilexetil hydrochlorothiazide/|Hydroxyl radical reaction rate constant = 4.96X10-11 cu cm/molec-sec at 25 °C (est)

See More Candesartan Properties 

Hazard Identification

Classification of the substance or mixture

Reproductive toxicity, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H361 Suspected of damaging fertility or the unborn child
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Candesartan Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP

Location:
1613 Guangyin Building,No.42 E.Fengqi Road,Hangzhou,310012 China.

Payment Terms:
TT against copy of documents,L/C

Average lead Time:
7 days

Total Annual Revenue:
$25 million-$50 million

Total Employees:
11-50

Year of Establishment:
2011

Dawn Ray is a R&D and process improvement company,which is located in Hangzhou, Zhejiang province,China.We are dealing in multi-application of pharmaceuticals(APIs),antibiotics,food additives,peptides and plant extracts.

Dawn Ray has a wide range of products from milligram up to thousands of kilogram quantities.We are also increasing our breed all the time.Our products have been exported all over the world and have a good reputation.

Dawn Ray promises that we can offer you qualified products and excellent service in good prices.Our aim is "Best goods,best service".We sincerely invite customers from all over the world to visit our company,establish business relations and both get win.

Process Capacity: Synthetic,Ferment,extract

After-sale Service:24 hours on skype for business

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Candesartan	2000 KG	May 26, 2025

Post an enquiry for this product

More Choices Find All Products for Sale 

Product Name	Grade / Content	Supplier Name	Details
Candesartan	/99.00	HANGZHOU LEAP CHEM CO., LTD.	Inquiry
Cost-effective sourcing of 99% pure Candesartan CAS 139481-59-7 raw material	Pharmaceutical Grade/99	Xi'an Honest BioEngr Co.,Ltd.	Inquiry
Candesartan 99%	/98	Conier Chem&Pharma Limited	Inquiry
High Quality Intermediates Candesartan CAS: 139481-59-7	/0.00	SHANDONG LOOK CHEMICAL CO.,LTD	Inquiry
Candesartan	/99	Creative Enzymes	Inquiry

Hot Related Products



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.

Candesartan 139481-59-7

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

Related Products

More Choices Find All Products for Sale 

Related Searches

More from this Seller

Hot Related Products