Best Quality 99% Ascorbyl Palmitate CAS:137-66-6 Food Grade BP/USP/FCC/Ph.Eur./E304

S-ASCORBIC ACID

6-O-Palmitoyl ascorbate;Palmitoyl ascorbate;

L-Ascorbic Acid 2-Glucoside

D-Isoascorbic acid

3-O-Ethyl Ascorbic Acid

​​Ascorbyl Palmitate: A Stable, Fat-Soluble Derivative of Vitamin C for Enhanced Formulation Versatility​​

Ascorbyl palmitate is a highly functional and scientifically validated ester formed by the conjugation of ascorbic acid (vitamin C) with palmitic acid, a naturally occurring fatty acid. This unique molecular structure combines the potent antioxidant properties of vitamin C with the lipid-soluble characteristics of palmitate, resulting in a versatile ingredient widely utilized in food, cosmetic, and nutraceutical applications. Its stability, efficacy, and multifunctional benefits make it a preferred choice for formulations requiring oxidation resistance, skin rejuvenation, or enhanced bioavailability.

​​Chemical Properties and Stability​​
Unlike pure ascorbic acid, which is water-soluble and prone to rapid degradation in the presence of light, heat, and oxygen, ascorbyl palmitate exhibits superior stability due to its lipophilic nature. The esterification process enhances its resistance to oxidation, allowing it to remain effective in lipid-based systems such as oils, emulsions, and anhydrous formulations. This stability is particularly advantageous in products with prolonged shelf-life requirements or those exposed to environmental stressors.

Ascorbyl palmitate functions as an antioxidant by donating electrons to neutralize free radicals, thereby preventing lipid peroxidation and oxidative rancidity. Its dual solubility profile—moderate solubility in oils and limited solubility in water—enables its incorporation into a broad range of delivery systems, including creams, serums, softgels, and fortified foods.

​​Mechanisms of Action and Benefits​​
​​Antioxidant Protection​​
Ascorbyl palmitate effectively scavenges reactive oxygen species (ROS), including superoxide anions and hydroxyl radicals, which contribute to cellular damage and premature aging. In topical applications, it helps mitigate UV-induced oxidative stress, supporting collagen synthesis and reducing visible signs of photoaging.
​​Skin Health and Cosmetic Applications​​
Due to its ability to penetrate the lipid-rich layers of the stratum corneum, ascorbyl palmitate is a valuable ingredient in anti-aging and brightening skincare formulations. It inhibits melanogenesis, promoting a more even skin tone, while stimulating fibroblast activity to enhance collagen production. Studies suggest that its lipophilic nature allows for sustained release, prolonging its efficacy compared to water-soluble vitamin C derivatives.
​​Food and Nutraceutical Stabilization​​
In the food industry, ascorbyl palmitate serves as a preservative to extend the freshness of oils, snacks, and processed foods by preventing oxidative spoilage. It is often combined with other antioxidants, such as tocopherols, to create synergistic effects. In dietary supplements, it provides a stable source of vitamin C, particularly in fat-soluble matrices where traditional ascorbic acid would degrade.
​​Bioavailability and Metabolic Conversion​​
Upon ingestion or dermal absorption, ascorbyl palmitate is hydrolyzed by esterases into free ascorbic acid and palmitic acid, both of which are metabolized naturally. This controlled release mechanism ensures optimal bioavailability while minimizing gastrointestinal irritation associated with high doses of pure ascorbic acid.
​​Regulatory and Safety Profile​​
Ascorbyl palmitate is generally recognized as safe (GRAS) by regulatory agencies for use in food and cosmetics. It is compliant with international standards, including those set by the FDA, EFSA, and COSMOS certification for organic formulations. Safety assessments indicate low risk of irritation or sensitization, making it suitable for sensitive skin types when used at recommended concentrations (typically 0.1–3%).

​​Formulation Considerations​​
To maximize efficacy, ascorbyl palmitate should be incorporated into lipid phases at temperatures below its decomposition point (∼110°C). In emulsions, pairing it with chelating agents (e.g., EDTA) can further enhance stability by sequestering pro-oxidant metal ions. For topical products, combining it with vitamin E or ferulic acid amplifies photoprotective effects.

​​Conclusion​​
Ascorbyl palmitate represents an advanced fusion of vitamin C’s bioactive potential with the practical advantages of lipid solubility. Its multifaceted role as an antioxidant, stabilizer, and skin-repair agent underscores its utility across industries. Whether employed to fortify anti-aging serums, preserve functional foods, or improve supplement delivery, this ingredient exemplifies innovation in bioactive chemistry—delivering science-backed benefits without compromising stability or safety.

For formulations seeking a robust, non-irritating, and multifunctional antioxidant, ascorbyl palmitate remains a gold-standard choice.