High Quality EP/JP/KP Standard Trimebutine maleate CAS 34140-59-5 with best price and fast felivery

Trimebutine maleate More Info

Trimebutine maleate is a pharmaceutical compound primarily used in the treatment of functional gastrointestinal disorders, particularly irritable bowel syndrome (IBS). It has been in use since the late 1960s and is recognized for its multifaceted pharmacological properties, making it effective in managing various gastrointestinal symptoms.

Mechanism of Action

Trimebutine exerts its effects through several mechanisms:
Opiate Receptor Agonism: It acts as an agonist on peripheral mu, kappa, and delta opiate receptors, which helps in modulating pain and gastrointestinal motility.
Gastrointestinal Peptide Modulation: Trimebutine influences the release of various gastrointestinal peptides, including motilin, vasoactive intestinal peptide, gastrin, and glucagon, which are crucial for digestive processes.
Motor Activity Regulation: It accelerates gastric emptying and induces phase III of the migrating motor complex in the intestines, while also modulating colonic contractility. This dual action allows it to alleviate both constipation and diarrhea associated with IBS.

Applications

Irritable Bowel Syndrome (IBS): It effectively relieves symptoms such as abdominal pain, cramps, and irregular bowel movements.
Functional Gastrointestinal Disorders: Used to treat various conditions characterized by gastrointestinal discomfort and dysmotility.
Postoperative Recovery: It can aid in restoring normal gut motility after surgical procedures.

Routes of Administration

Trimebutine maleate is typically administered orally in tablet form. The usual dosage ranges from 300 to 600 mg per day, divided into multiple doses based on individual patient needs.

Safety and Side Effects

Common Side Effects
Patients taking trimebutine may experience:
Nausea
Diarrhea
Constipation
Dry mouth
Dizziness
Fatigue
Abdominal pain
Foul taste
Serious Side Effects
More severe adverse effects can include:
Allergic Reactions: Symptoms such as rash or difficulty breathing may occur.
Neurological Symptoms: In cases of overdose or misuse, symptoms may include loss of consciousness or convulsions.
Cardiac Issues: Rarely reported but can include bradycardia or other arrhythmias.

Pharmacokinetics

Absorption and Distribution
Trimebutine is well absorbed from the gastrointestinal tract, with peak plasma concentrations typically reached within 1 to 2 hours after oral administration.
Metabolism and Excretion
The drug is primarily metabolized in the liver and excreted through urine. Its half-life allows for effective management of symptoms throughout the day.
Special Considerations
Due to its effects on the central nervous system, patients should be cautious when performing tasks that require alertness until they know how trimebutine affects them.

Package Image

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.