Name | Trimebutine maleate |
CAS number | 34140-59-5 |
EINECS number | 251-845-9 |
Synonym | Trimebutine Maleate; Debridat; Polibutin; Modulon; Dromostat; EINECS 251-845-9; Ibutin; Polibutin; TM 906; Trimebutine maleate, Trimedat; [2-(dimethylamino)-2-phenylbutyl] 3,4,5-trimethoxybenzoate Maleate |
Description | Trimebutine maleate is a medication primarily used for the treatment of gastrointestinal disorders, including irritable bowel syndrome (IBS), functional dyspepsia, and postoperative ileus. It functions as a prokinetic agent that directly affects the smooth muscle of the gastrointestinal tract, regulating both hypo- and hyper-motility depending on the specific receptor subtypes activated. |
Structure |  |
Molecular Formula | C26H33NO9 |
Molecular Weight | 503.54 g/mol |
Appearance | Solid powder |
Quality Standard | KP/JP/EP Standard |
Assay | ≥98% |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Storage Condition | Store in cool place. Keep container tightly closed in a dry and well ventilated place. |
Shelf Life | >2 years if stored properly |
Sample package | Aluminium foil bag |
Commercial package | Aluminium Tin, Fiber drum |
Origin | China |
HS Code | 2922199090 |
Trimebutine maleate More Info
Trimebutine maleate is a pharmaceutical compound primarily used in the treatment of functional gastrointestinal disorders, particularly irritable bowel syndrome (IBS). It has been in use since the late 1960s and is recognized for its multifaceted pharmacological properties, making it effective in managing various gastrointestinal symptoms.
Mechanism of Action
Trimebutine exerts its effects through several mechanisms:
Opiate Receptor Agonism: It acts as an agonist on peripheral mu, kappa, and delta opiate receptors, which helps in modulating pain and gastrointestinal motility.
Gastrointestinal Peptide Modulation: Trimebutine influences the release of various gastrointestinal peptides, including motilin, vasoactive intestinal peptide, gastrin, and glucagon, which are crucial for digestive processes.
Motor Activity Regulation: It accelerates gastric emptying and induces phase III of the migrating motor complex in the intestines, while also modulating colonic contractility. This dual action allows it to alleviate both constipation and diarrhea associated with IBS.
Applications
Irritable Bowel Syndrome (IBS): It effectively relieves symptoms such as abdominal pain, cramps, and irregular bowel movements.
Functional Gastrointestinal Disorders: Used to treat various conditions characterized by gastrointestinal discomfort and dysmotility.
Postoperative Recovery: It can aid in restoring normal gut motility after surgical procedures.
Routes of Administration
Trimebutine maleate is typically administered orally in tablet form. The usual dosage ranges from 300 to 600 mg per day, divided into multiple doses based on individual patient needs.
Safety and Side Effects
Common Side Effects
Patients taking trimebutine may experience:
Nausea
Diarrhea
Constipation
Dry mouth
Dizziness
Fatigue
Abdominal pain
Foul taste
Serious Side Effects
More severe adverse effects can include:
Allergic Reactions: Symptoms such as rash or difficulty breathing may occur.
Neurological Symptoms: In cases of overdose or misuse, symptoms may include loss of consciousness or convulsions.
Cardiac Issues: Rarely reported but can include bradycardia or other arrhythmias.
Pharmacokinetics
Absorption and Distribution
Trimebutine is well absorbed from the gastrointestinal tract, with peak plasma concentrations typically reached within 1 to 2 hours after oral administration.
Metabolism and Excretion
The drug is primarily metabolized in the liver and excreted through urine. Its half-life allows for effective management of symptoms throughout the day.
Special Considerations
Due to its effects on the central nervous system, patients should be cautious when performing tasks that require alertness until they know how trimebutine affects them.
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