99% N-ETHYL-4-HYDROXYPIPERIDINE 3518-83-0

N-Ethyl-4-hydroxypiperidine More Info

N-Ethyl-4-hydroxypiperidine typically appears as a colorless to pale yellow viscous liquid at room temperature, though it may crystallize into a low-melting solid when cooled below 15°C. The compound exhibits moderate viscosity similar to light machine oil and possesses a characteristic amine-like odor that becomes more pronounced upon exposure to air. It demonstrates excellent solubility in water and most common organic solvents . The material shows stability under normal storage conditions but may gradually darken upon prolonged exposure to air or light. Optimal preservation requires storage in tightly sealed amber glass containers under inert atmosphere at temperatures between 2-8°C, with some suppliers recommending the addition of stabilizers for long-term storage.

Introduction

This heterocyclic organic compound features both a hydroxyl group and a tertiary amine group on a six-membered piperidine ring, making it a versatile intermediate in organic synthesis. The presence of these two functional groups at the 1 and 4 positions creates unique reactivity patterns that facilitate its use in various chemical transformations. The ethyl substitution on the  atom influences both the basicity of the amine and the compound's overall lipophilicity. In solution, it can act as both a hydrogen bond donor (through the hydroxyl group) and acceptor , giving it interesting solvent properties. The molecule's conformational flexibility allows it to adapt to different chemical environments, contributing to its utility in multiple applications.

Source

N-Ethyl-4-hydroxypiperidine is primarily produced through synthetic organic routes, most commonly via the reduction of N-ethyl-4-piperidone or through the nucleophilic substitution reactions of 4-hydroxypiperidine. Industrial production occurs in specialized chemical facilities equipped to handle amine chemistry, with typical batch sizes ranging from kilograms to metric tons. The synthesis involves multiple purification steps including distillation under reduced pressure or recrystallization to achieve technical (95-98%) or higher purity grades (99%+). For laboratory use, it's available through fine chemical suppliers in quantities from 100g to several kilograms, with packaging options including glass bottles, metal cans, or specialized chemical-resistant plastic containers depending on quantity and customer requirements.

Uses

This compound serves as a valuable building block in pharmaceutical synthesis, particularly for creating active pharmaceutical ingredients with piperidine moieties. Its applications extend to the production of various therapeutic agents including antipsychotics, analgesics, and antiviral medications. In material science, it functions as a monomer or modifier in polymer synthesis, contributing to the development of specialty resins and coatings. The compound also finds use as a catalyst or co-catalyst in certain organic transformations, particularly those requiring both basic and nucleophilic character. Additional applications include its use as a corrosion inhibitor in industrial formulations and as a precursor for more complex nitrogen-containing compounds in research settings.

Applications

Pharmaceutical applications include:

Intermediate for serotonin receptor modulators

Precursor to local anesthetic compounds

Building block for kinase inhibitor development

Industrial applications encompass:

Additive for polyurethane formulations

Component in epoxy curing systems

Ingredient in specialty adhesive formulations

Research applications involve:

Studies of molecular recognition in host-guest chemistry

Development of ionic liquids for green chemistry

Investigations into structure-activity relationships

Specialty uses include:

Chiral auxiliary in asymmetric synthesis

Ligand for metal complexation

Template molecule for molecular imprinting

Precautions

Important safety considerations include:

Personal protection: Requires chemical-resistant gloves (nitrile or neoprene), safety goggles, and proper ventilation due to moderate volatility

Storage conditions: Best preserved under nitrogen atmosphere in corrosion-resistant containers away from oxidizers

Fire safety: Combustible liquid requiring appropriate fire suppression systems (alcohol-resistant foam preferred)

Spill management: Absorb with inert material and dispose as hazardous waste

First aid measures: Immediate flushing with water for eye contact, removal of contaminated clothing for skin exposure

Environmental precautions: Prevent entry into waterways or sewage systems

Regulatory status: Verify local regulations as classification may vary by jurisdiction

Stability concerns: Potential for peroxide formation with long-term storage requires periodic testing

Incompatibilities: Avoid strong acids, oxidizing agents, and reactive metals

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
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Suitable for more than 50kg 
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By Sea
Suitable for more than 500kg      
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We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.