Name | Nicotinamide riboside |
CAS number | 1341-23-7 |
Description | Nicotinamide riboside is a derivative of vitamin B3. It appears as a white or pale yellow crystalline powder, odorless with a bitter taste, and slight hygroscopicity. It is primarily used in the field of biochemical engineering. |
Structural formula | |
Molecular Formula | C11H15N2O5+ |
Molecular Weight | 255.25 g/mol |
Appearance | White powder |
Quality Standard | 99% |
Storage Condition | Store at -20°C |
Shelf Life | >2 years if stored properly |
Sample package | Aluminium foil bag |
Commercial package | Aluminium Tin, Fiber drum |
Origin | China |
Ciclopirox ethanolamine More Info
Nicotinamide riboside is a derivative of vitamin B3. It appears as a white or pale yellow crystalline powder, odorless with a bitter taste, and slight hygroscopicity. It is primarily used in the field of biochemical engineering.
Nicotinamide riboside (NR) is a derivative of vitamin B3 that can combine with phosphate and adenine to form nicotinamide adenine dinucleotide (NAD, also known as Coenzyme I) and nicotinamide adenine dinucleotide phosphate (NADP, also known as Coenzyme II). It is an important precursor to the essential coenzyme NAD+.
Nicotinamide riboside plays a crucial role in cellular energy production in human cells. It participates in the synthesis of nicotinamide adenine dinucleotide (NAD), a vital coenzyme involved in cellular energy conversion.
Industrial Applications of Nicotinamide Riboside (CAS 1341-23-7)
Nicotinamide riboside (NR) is increasingly utilized in the biochemical and pharmaceutical industries due to its role as a precursor to NAD+ (nicotinamide adenine dinucleotide), a critical coenzyme in cellular metabolism. Industrially, NR is employed in the production of high-value nutraceuticals and anti-aging supplements, where its stability and bioavailability make it a preferred NAD+ booster over other precursors like nicotinamide or nicotinic acid. Additionally, NR is used in microbial fermentation processes to enhance NAD+ levels in engineered bacteria and yeast, optimizing yields in the biosynthesis of pharmaceuticals, enzymes, and biofuels. Its hygroscopic nature requires controlled handling in industrial settings, often involving encapsulation or stabilization techniques to ensure product integrity during large-scale manufacturing.
Food and Dietary Applications of Nicotinamide Riboside (CAS 1341-23-7)
In the food and dietary supplement sector, nicotinamide riboside is marketed as an advanced form of vitamin B3, offering superior NAD+-boosting capabilities compared to traditional niacin. It is incorporated into functional foods, fortified beverages, and premium dietary supplements aimed at improving cellular energy metabolism, reducing oxidative stress, and supporting healthy aging. Regulatory agencies such as the FDA and EFSA have recognized NR as a Generally Recognized as Safe (GRAS) ingredient, allowing its use in meal replacement shakes, sports nutrition products, and longevity-focused formulations. Due to its bitter taste, NR is often microencapsulated or combined with flavor-masking agents in consumer products to improve palatability while maintaining efficacy.
Chemical and Research Applications of Nicotinamide Riboside (CAS 1341-23-7)
Chemically, nicotinamide riboside is a -nucleoside analog that serves as a key intermediate in synthetic pathways for NAD+ and its derivatives (NADP+). In research laboratories, NR is widely used to study mitochondrial function, sirtuin activation, and age-related metabolic decline, given its ability to efficiently elevate intracellular NAD+ levels. It also acts as a substrate for enzymatic assays and cell culture studies investigating metabolic disorders, neurodegenerative diseases, and cancer metabolism. Furthermore, NR’s crystalline form (CAS 1341-23-7) is employed in analytical chemistry as a reference standard for HPLC and mass spectrometry, ensuring quality control in both industrial and academic settings. Its stability under controlled conditions makes it a reliable reagent for biochemical and pharmacological research.
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