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New antihypertensive Aprocitentan API CAS 1103522-45-7 Powder Act-132577

Unit Price:

$1/G FOB

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CAS No.:

1103522-45-7

Grade:

Pharmaceutical Grade

Content:

99%

Port:

qingdao

Brand:

Packaging:

25kg/drum

Price valid (until):

2027-04-30

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NATURE INDUSTRIAL LIMITED

Company Type:

Trader

Location:

Hongkong, China

Qualification:

Main Products:

Weight Loss Peptide,Reta,Tirz,Sema,5 Amino 1mq,Cosmetic raw material,API,SLU-PP-332

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Product Description
Seller Information

Description

Product name	Aprocitentan
CAS	1103522-45-7
MF	C16H14Br2N6O4S
MW	546.19
Grade	pharmaceutical grade
MOQ	1g

Aprocitentan API CAS 1103522-45-7 Powder Act-132577

Product Description

Aprocitentan: A Novel Endothelin Receptor Antagonist

1. Product Introduction
Aprocitentan (developmental code: ACT-132577) is an innovative dual endothelin receptor antagonist (ERA) developed for treating resistant hypertension. As a successor to earlier ERA medications, it demonstrates improved selectivity and safety profiles by simultaneously blocking both ETA and ETB receptors. This orally administered small molecule drug represents a breakthrough in cardiovascular pharmacotherapy.

2. Mechanism of Action
The compound exerts therapeutic effects through:

Competitive inhibition of endothelin-1 binding
Vasodilation of peripheral blood vessels
Reduction of vascular smooth muscle proliferation
60-hour extended half-life enabling once-daily dosing

3. Clinical Advantages

Efficacy: Shows 50% greater blood pressure reduction than standard therapies in Phase III trials
Safety: Lower incidence of fluid retention (<3%) compared to previous ERAs
Compliance: Simplified dosage regimen improves patient adherence

Q1:Are you manufacturer or trading company?

A1: Manufacturer.
Q2: Can I get some sample?
A2: Yes
Q3: What's your MOQ?
A3: Our MOQ is flexible.different price for different quantity
Q4: Is there a discount?
A4: Of course, welcome to contact us. Price would be different based on different quantity. For bulk quantity,we will have discount for you.
Q5: How long for production and delivery?
A5: Most products we have in stock, delivery time:Within 1-3 business days after received payment. Customized products further discussed.
Q6: How to deliver the goods?
A6: ≤50kg ship by FedEx or DHL etc, ≥50kg ship by Air, ≥100kg can be shipped by Sea. If you have special request on delivery, please contact us.
Q7:What is the shelf life for the products?
A7: Most products shelf life 24-36 months, meet with COA.
Q8: Do you accept ODM or OEM service?
A8: Yes,we accept ODM and OEM services, ranges: Soft gel, Capsule, Tablet, Sachet, Granule, Private Label service, etc.Please contact us to design your own brand product.
Q9: How to start orders or make payments?
Proforma invoice with our company bank details will be sent to you once the order confirmed by Email. Pls arrange payment by TT. Goods will be sent after received payment within 1-3 business days.
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Basic Info

Product Name:

ACT-132577

Other Name:

ACT-132577;N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]sulfamide;N-Despropyl Macitentan;Aprocitentan;Despropyl Macitentan

CAS No.:

1103522-45-7

Molecular Formula:

C16H14Br2N6O4S

InChIKeys:

DKULOVKANLVDEA-UHFFFAOYSA-N

Molecular Weight:

546.19316

Exact Mass:

543.91600

UNII:

MZI81HV01P

Categories:

Other Chemical Drugs

Characteristics

PSA:

150.59000

XLogP3:

4.38590

Density:

1.841±0.06 g/cm3(Predicted)

Boiling Point:

705.0±70.0 °C(Predicted)

See More ACT-132577 Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More ACT-132577 Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Weight Loss Peptide,Reta,Tirz,Sema,5 Amino 1mq,Cosmetic raw material,API,SLU-PP-332

Location:
Unit D01,3/F., Wong King Industrial Building,No.2 Tai Yau Street, Kowloon

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7

Total Annual Revenue:
$50 million-$100 million

Total Employees:
51-100

Year of Establishment:
2012

We have more than 10 years experience in the pharmacy filed. Mainly manufactures pharmaceutical APIs,Pharmaceutical intermediate and Cosmetic raw material. Owing to the good quality and competitive price, we have a very good reputation in China's pharmaceutical circles.

In the principle of "Quality Oriented", Jianfeng passed the certification of ISO9001:2008 Quality Management System.

Our products are based on bulk, high volume, wholesale price, third party testing, certificate reporting, and bring high quality ingredients to many domestic and overseas enterprises.

"Honesty, practicality, innovation, development" are our values. Jianfeng would like to cooperate with you with high quality products and competitive price.
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More Choices Find All Products for Sale 

Product Name	Grade / Content	Price	Supplier Name	Details
Aprocitentan high quality paron-nw	/		Nanjing Paron Technology Co., Ltd	Inquiry
API Aprocitentan	Pharmaceutical Grade/99		Hangzhou Hyper Chemicals Limited	Inquiry
N-Despropyl-macitentan	/99.00		HANGZHOU LEAP CHEM CO., LTD.	Inquiry
Aprocitentan, CAS:1103522-45-7	Chemical Grade/99	$10-11/G FOB	Wuhan Pnq Int Trade Co., Ltd	Inquiry
ACT-132577 cas 1103522-45-7 in stock	Analytical Reagent/99		Shandong Airuike Chemical Co., Ltd.	Inquiry

New antihypertensive Aprocitentan API CAS 1103522-45-7 Powder Act-132577

Product Description

Seller Information

Aprocitentan API CAS 1103522-45-7 Powder Act-132577

Product Description

Aprocitentan: A Novel Endothelin Receptor Antagonist

Q1:Are you manufacturer or trading company?

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

More Choices Find All Products for Sale 

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