98% Glycyrrhizic acid 1405-86-3

ABT-199 More Info

ABT-199, with CAS registry number 1257044-40-8, is a highly selective and potent small-molecule inhibitor specifically designed to target B-cell lymphoma 2 (BCL-2) protein. Developed through collaborative research between AbbVie and Roche, it represents a significant advancement in the field of precision oncology. Its mechanism of action involves disrupting the interaction between BCL-2 and pro-apoptotic proteins, thereby restoring programmed cell death in malignant cells. This innovative approach addresses a key survival mechanism in certain cancers, particularly those dependent on BCL-2 for evasion of apoptosis.

Primary Uses and Applications

ABT-199 is primarily utilized in the treatment of hematologic malignancies, including chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), and non-Hodgkin’s lymphomas. It is approved for use in specific patient populations, such as those with relapsed or refractory CLL with 17p deletion, and is often administered in combination with other anticancer agents. Beyond its established indications, ongoing clinical investigations explore its potential in other BCL-2-dependent cancers and as part of novel therapeutic regimens. Its targeted nature minimizes off-target effects compared to traditional chemotherapy.

Application Market

The market for ABT-199 is specialized and primarily driven by the demand in oncology therapeutics, particularly within the hematology segment. It is supplied globally through regulated pharmaceutical channels and is available under various brand names, depending on the region. As a prescription drug, its distribution is strictly controlled, targeting healthcare providers, cancer treatment centers, and hospitals specializing in oncology. The product is supported by extensive clinical data and is often covered under insurance and healthcare systems in markets such as North America, Europe, and parts of Asia.

Handling and Regulatory Considerations

As an active pharmaceutical ingredient (API) and finished drug product, ABT-199 is subject to stringent regulatory oversight by health authorities like the U.S. FDA and EMA. It must be handled in accordance with Good Manufacturing Practice (GMP) guidelines, and all activities related to its production, distribution, and dispensing require compliance with regional pharmaceutical regulations. Access is restricted to qualified medical professionals, and its use is limited to approved indications under professional supervision. Safety data sheets and prescribing information should be consulted for detailed handling, storage, and administration guidelines.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.