High Quality USP Standard Yellow Powder Isotretinoin CAS 4759-48-2 for acne treatment

Isotretinoin More Info

Isotretinoin is a powerful oral retinoid primarily used to treat severe forms of acne, particularly nodular acne that has not responded to other treatments. It was approved by the FDA in 1982 and is known for its efficacy in reducing acne severity by targeting multiple factors contributing to acne development.

Mechanism of Action

Isotretinoin works through several mechanisms:
Sebocyte Apoptosis: It induces apoptosis (programmed cell death) in sebaceous gland cells, significantly reducing sebum production, which is a major contributor to acne formation.
Reduction of Comedogenesis: The drug decreases hyperkeratinization, which prevents clogged pores.
Anti-inflammatory Properties: Isotretinoin also exhibits anti-inflammatory effects, further aiding in the reduction of acne lesions.
Influence on Cell Cycle: It affects cellular differentiation and survival, impacting the overall skin health and reducing the proliferation of Propionibacterium acnes, the bacteria associated with acne.

Applications

Isotretinoin is primarily indicated for:
1. Severe nodular acne
2. Off-label uses include treatment for conditions such as:
Moderate acne
Cutaneous T-cell lymphomas
Neuroblastoma
Prevention of squamous cell carcinoma in high-risk patients
Rosacea and pyoderma faciale

Routes of Administration

Isotretinoin is administered orally in capsule form. Various brands include Accutane, Claravis, and Amnesteem, with dosages typically ranging from 10 mg to 40 mg capsules

Safety and Side Effects

Teratogenic Effects: It can cause severe birth defects if taken during pregnancy. Women of childbearing age must use effective contraception during treatment.
Neurological Effects: Patients may experience severe headaches, blurred vision, dizziness, and even seizures or strokes.
Gastrointestinal Issues: There are reports of inflammatory bowel disease (IBD) and pancreatitis associated with isotretinoin use.
Skin Reactions: Severe skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis can occur.
Psychiatric Effects: Some patients report depression and suicidal ideation, although the correlation remains controversial.

Pharmacokinetics

Absorption: Rapidly absorbed after oral administration; food can enhance absorption rates.
Protein Binding: Isotretinoin is highly bound to plasma proteins (over 99%), primarily albumin.
Metabolism: It is metabolized primarily in the liver to several active metabolites, including 4-oxo-isotretinoin. The half-life for isotretinoin ranges from 10 to 20 hours, while its primary metabolite has a longer half-life of about 24 to 29 hours.
Elimination: Excreted through urine and feces; significant first-pass metabolism occurs during initial processing by the liver.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

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HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.