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99% High Quality Paclitaxel with Best Price

Name: 99% High Quality Paclitaxel with Best Price
Brand: HyperChem
SKU: pr2509191360
Price: 20 USD
Availability: InStock

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CAS No.:

33069-62-4

Grade:

Pharmaceutical Grade

Content:

99%

Port:

SHANGHAI

Brand:

HyperChem

Packaging:

1kg/Bag, 25kg/drum

Sample Available:

Yes

Price valid (until):

2025-10-19

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Details
Seller Information
Inquiry History

Description

Name	Paclitaxel
CAS number	33069-62-4
Description	Paclitaxel is a complex diterpenoid natural product originally isolated from the bark of the Pacific yew tree (Taxus brevifolia) in the 1960s during a large-scale plant screening program by the U.S. National Cancer Institute.
Structural formula
Molecular Formula	C47H51NO14
Molecular Weight	853.92 g/mol
Appearance	White powder
Quality Standard	99%
Storage Condition	Cool dry place( away from the light)
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Paclitaxel More Info

Paclitaxel is a complex diterpenoid natural product originally isolated from the bark of the Pacific yew tree (Taxus brevifolia) in the 1960s during a large-scale plant screening program by the U.S. National Cancer Institute. Its unique mechanism of action, discovered later, distinguished it from other antimitotic agents; it specifically promotes the assembly of microtubules and stabilizes them by preventing depolymerization, thereby arresting cell division in the G2/M phase of the cell cycle and leading to apoptosis (programmed cell death) in rapidly dividing cells. The initial reliance on tree bark, which threatened the yew population and was not sustainable for large-scale production, led to the development of alternative methods, including semi-synthesis from a precursor found in the needles of more abundant yew species, and eventually plant cell fermentation technology, which is now a primary commercial production method.

Uses and Applications

The primary application of Paclitaxel is as a potent chemotherapeutic agent in oncology. It is a cornerstone in the treatment of a wide range of solid tumors, including ovarian cancer, breast cancer, non-small cell lung cancer (NSCLC), and Kaposi's sarcoma. It is also used in the treatment of other malignancies, often in combination with other chemotherapeutic agents. Beyond its injectable form for systemic chemotherapy, its application has been expanded through novel drug delivery systems, most notably in drug-eluting stents used in interventional cardiology and radiology. In this context, it is applied to the stent surface to inhibit vascular smooth muscle cell proliferation and prevent restenosis (re-narrowing) of arteries after angioplasty.

Application Market

The market for Paclitaxel is a high-value segment within the global oncology drug market. Despite the introduction of many generic versions following patent expirations, it remains an essential and widely used chemotherapeutic agent, securing its place on the World Health Organization's List of Essential Medicines. The market is bifurcated: one segment is the supply of the active pharmaceutical ingredient (API) for injectable chemotherapeutic formulations, and the other is its specialized use in the multi-billion dollar market for drug-eluting medical devices, primarily stents. Demand is steady and global, driven by the high incidence of cancers for which it is a standard of care. Production is dominated by specialized pharmaceutical companies utilizing advanced biotechnological fermentation and synthesis processes.

Important Considerations

Paclitaxel is a highly potent cytotoxic compound that requires extreme caution in handling. In a clinical setting, its administration is associated with serious potential adverse effects, including severe hypersensitivity reactions (necessitating premedication), myelosuppression (neutropenia), peripheral neuropathy, and alopecia. It must be administered under the supervision of a qualified oncologist in a setting equipped to manage such complications. In an industrial or laboratory environment, strict containment procedures are mandatory. Handling the pure API requires the use of specialized personal protective equipment (PPE) and engineering controls (e.g., closed systems, glove boxes) to prevent any occupational exposure through inhalation, skin contact, or ingestion, as it poses significant health risks. It is for use only in finished, professionally administered dosage forms.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express
FedEx UPS DHL EMS
Fast: 3-7 days around, high cost, door to door service

By Air
Suitable for more than 50kg
Fast: 3-7 days, hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Fast: 7-45 days, low cost, port to port, professional broker needed

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders:
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

ECHEMI Editorial Reference

Taxol appears as needles (from aqueous methanol) or fine white powder. An anti-cancer drug.|LSM-1400 is a taxane diterpenoid.|Paclitaxel is an antineoplastic agent which acts by inhibitor of cellular mitosis and which currently plays a central role in the therapy of ovarian, breast, and lung cancer. Therapy with paclitaxel has been associated with a low rate of serum enzyme elevations, but has not been clearly linked to cases of clinically apparent acute liver injury.

Certificates

Basic Info

Product Name:

Paclitaxel

Other Name:

Benzenepropanoic acid,β-(benzoylamino)-α-hydroxy-,(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester,(αR,βS)-;Tax-11-en-9-one,5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxy-,4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine;Benzenepropanoic acid,β-(benzoylamino)-α-hydroxy-,6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester,[2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-;7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.;Taxol;NSC 125973;Taxol A;Paclitaxel;BMS 181339-01;Yewtaxan;Plaxicel;ABI 007;TaxAlbin;QW 8184;Ebetaxel;Capxol;MBT 0206;Abraxane;Genexol-PM;Pacliex;Genexol;Genetaxyl;NK 105;Mitotax;OncoGel;Onxal;DHP 107;EndoTAG 1;Genaxol;Intaxel;Taxus;TAXUS stent;(-)-Paclitaxel;Taxus Liberte;EmPAC;Tocosol Paclitaxel;Cyclopax;Zisu;LEP-ETU;Liposome-entrapped paclitaxel easy-to-use;Paxene;Infinnium;Padexol;Sindaxel;Nanoxel;5β,20-Epoxy-1,2a,4,7β,10β,13α-hexahydroxy-tax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine;PTX;Cypher select;Coroflex Please;Nab-paclitaxel;TAXUS Express;IG 001;Cynviloq;IG 002;157069-30-2;1203669-79-7;2376186-34-2

CAS No.:

33069-62-4

Molecular Formula:

C47H51NO14

InChIKeys:

RCINICONZNJXQF-MZXODVADSA-N

Molecular Weight:

853.9

Exact Mass:

853.331

EC Number:

608-826-9

NSC Number:

358882

UN Number:

2811

DSSTox ID:

DTXSID9023413

Color/Form:

White to off-white crystalline powder; Needles from aqueous methanol

HScode:

2932999021

Categories:

Antispasticity Agents

Characteristics

PSA:

221.29000

Physical Properties:

Taxol appears as needles (from aqueous methanol) or fine white powder. An anti-cancer drug.; Solid; [Merck Index] White to off-white solid; [HSDB] Powder; [Sigma-Aldrich MSDS]; Solid

XLogP3:

3 Log10 unitless

Appearance:

Taxol appears as needles (from aqueous methanol) or fine white powder. An anti-cancer drug.

Density:

1.45003

Melting Point:

216.5 °C

Boiling Point:

858.903

Flash Point:

492.88

Refractive Index:

1.637

Water Solubility:

4e-07 mol/L

Storage Conditions:

Commercially available albumin-bound paclitaxel for injectable suspension should be stored in unopened vials at 20-25 °C and retained in the original package for protection from bright light. Neither freezing nor refrigeration adversely affects albumin-bound paclitaxel for injectable suspension. When stored under recommended conditions, unopened vials of commercially available albumin-bound paclitaxel for injectable suspension are stable until the date indicated on the package. /Paclitaxel (albumin-bound)/; The manufacturer states that, when diluted as directed, paclitaxel solutions are stable for up to 27 hours when stored at approximately 25 °C under ambient lighting conditions.; Commercially available paclitaxel for injection concentrate should be stored in unopened vials at 20-25 °C and retained in the original package for protection from light. Neither freezing nor refrigeration adversely affects paclitaxel for injection concentrate. Refrigeration may result in precipitation of the drug or formulation vehicle; however, the precipitate typically will dissolve at room temperature without loss of potency. If freezing occurs, paclitaxel for injection concentrate may be thawed at room temperature until precipitate dissolves; the manufacturer states that the chemical or physical stability of the injection is not affected. If the solution remains cloudy or if an insoluble precipitate remains at room temperature, the vial should be discarded. When stored under recommended conditions, unopened vials of commercially available paclitaxel for injection concentrate are stable until the date indicated on the package.

Vapor Pressure:

2.06728e-15

Toxicity:

Currently, no known antidote for paclitaxel overdosage exists. The primary expected complications of overdosage would typically involve bone marrow suppression, peripheral neurotoxicity, and mucositis. However, it is noteworthy that hyaluronidase is commonly utilized as an antidote for addressing paclitaxel extravasation. If the needle or cannula is still in place, it is advised to administer 1 to 6 mL of hyaluronidase into the existing IV line. If the needle or cannula is no longer inserted, healthcare providers may inject the hyaluronidase subcutaneously, encircling the area of extravasation clockwise. This procedure may be repeated several times over the next 3 to 4 hours. Paclitaxel interferes with the normal function of microtubule growth. Whereas drugs like colchicine cause the depolymerization of microtubules in vivo, paclitaxel arrests their function by having the opposite effect; it hyper-stabilizes their structure. This destroys the cell's ability to use its cytoskeleton in a flexible manner. Specifically, paclitaxel binds to the β subunit of tubulin. Tubulin is the 'building block' of mictotubules, and the binding of paclitaxel locks these building blocks in place. The resulting microtubule/paclitaxel complex does not have the ability to disassemble. This adversely affects cell function because the shortening and lengthening of microtubules (termed dynamic instability) is necessary for their function as a transportation highway for the cell. Chromosomes, for example, rely upon this property of microtubules during mitosis. Further research has indicated that paclitaxel induces programmed cell death (apoptosis) in cancer cells by binding to an apoptosis stopping protein called Bcl-2 (B-cell leukemia 2) and thus arresting its function. Paclitaxel has been associated with serum aminotransferase elevations in 7% to 26% of patients, but values greater than 5 times the upper limit of normal (ULN) in only 2% of those receiving the highest doses. Similar rates of alkaline phosphatase elevations and occasional mild bilirubin elevations also occur. The abnormalities are usually asymptomatic, mild and self-limited, rarely requiring dose modification or discontinuation. Paclitaxel has not been linked convincingly to instances of delayed, idiosyncratic clinically apparent liver injury with jaundice. However, the hypersensitivity reactions that occur with infusions of paclitaxel can be severe and accompanied by acute hepatic necrosis. The liver injury may be relatively mild and anicteric (Case 1), but can also be severe with rapid onset of multiorgan failure and death. At least one instance of acute liver failure following a hypersensitivity reaction to paclitaxel has been published in the literature and recent modifications of the product labels for paclitaxel and docetaxel mention the occurrence of toxic deaths following severe infusion reactions.

Specific rotation:

Specific optical rotation: -49 deg at 20 °C/D (methanol); UV max absorption 2 (methanol): 227, 273, nm (E= 29,800,1700)

PKA:

pKa Acidic Apparent: 9.0885; pKa Basic Apparent: -2.203; pKa Acidic Apparent: 6.16 Log10 unitless; pKa Basic Apparent: -2.203 Log10 unitless

OH:

1.04713e-10 cm^3/molecule*sec

Henrys Law Constant:

1.38038e-11

Collision Cross Section:

278.9 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Experimental Properties:

Clear colorless to slightly yellow viscous solution /Paclitxel Injection USP/

Air and Water Reactions:

May be sensitive to prolonged exposure to moisture. (NTP, 1992).

Reactive Group:

Alcohols and Polyols

See More Paclitaxel Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Skin sensitization, Category 1

Serious eye damage, Category 1

Specific target organ toxicity â single exposure, Category 3

Reproductive toxicity, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 4

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H315 Causes skin irritation H317 May cause an allergic skin reaction H318 Causes serious eye damage H335 May cause respiratory irritation H361 Suspected of damaging fertility or the unborn child H413 May cause long lasting harmful effects to aquatic life
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area. P203 Obtain, read and follow all safety instructions before use. P273 Avoid release to the environment.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P333+P317 If skin irritation or rash occurs: Get medical help. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell. P318 IF exposed or concerned, get medical advice.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Paclitaxel Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Company Certificates
- Certification Report by Bureau Veritas
About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

5 Inquiries

Country	Product	Purchase Quantity	Date Posted
Algeria	Paclitaxel	5 G	Apr 16, 2025
United States	paclitaxel	25 G	Oct 11, 2024
India	Paclitaxel	1 KG	Feb 16, 2026
India	Paclitaxel	10 KG	Jul 8, 2024
India	Paclitaxel	5 G	Feb 9, 2024

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99% High Quality Paclitaxel with Best Price

Product Details

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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