99% High Quality Paclitaxel with Best Price

Paclitaxel More Info

Paclitaxel is a complex diterpenoid natural product originally isolated from the bark of the Pacific yew tree (Taxus brevifolia) in the 1960s during a large-scale plant screening program by the U.S. National Cancer Institute. Its unique mechanism of action, discovered later, distinguished it from other antimitotic agents; it specifically promotes the assembly of microtubules and stabilizes them by preventing depolymerization, thereby arresting cell division in the G2/M phase of the cell cycle and leading to apoptosis (programmed cell death) in rapidly dividing cells. The initial reliance on tree bark, which threatened the yew population and was not sustainable for large-scale production, led to the development of alternative methods, including semi-synthesis from a precursor found in the needles of more abundant yew species, and eventually plant cell fermentation technology, which is now a primary commercial production method.

Uses and Applications

The primary application of Paclitaxel is as a potent chemotherapeutic agent in oncology. It is a cornerstone in the treatment of a wide range of solid tumors, including ovarian cancer, breast cancer, non-small cell lung cancer (NSCLC), and Kaposi's sarcoma. It is also used in the treatment of other malignancies, often in combination with other chemotherapeutic agents. Beyond its injectable form for systemic chemotherapy, its application has been expanded through novel drug delivery systems, most notably in drug-eluting stents used in interventional cardiology and radiology. In this context, it is applied to the stent surface to inhibit vascular smooth muscle cell proliferation and prevent restenosis (re-narrowing) of arteries after angioplasty.

Application Market

The market for Paclitaxel is a high-value segment within the global oncology drug market. Despite the introduction of many generic versions following patent expirations, it remains an essential and widely used chemotherapeutic agent, securing its place on the World Health Organization's List of Essential Medicines. The market is bifurcated: one segment is the supply of the active pharmaceutical ingredient (API) for injectable chemotherapeutic formulations, and the other is its specialized use in the multi-billion dollar market for drug-eluting medical devices, primarily stents. Demand is steady and global, driven by the high incidence of cancers for which it is a standard of care. Production is dominated by specialized pharmaceutical companies utilizing advanced biotechnological fermentation and synthesis processes.

Important Considerations

Paclitaxel is a highly potent cytotoxic compound that requires extreme caution in handling. In a clinical setting, its administration is associated with serious potential adverse effects, including severe hypersensitivity reactions (necessitating premedication), myelosuppression (neutropenia), peripheral neuropathy, and alopecia. It must be administered under the supervision of a qualified oncologist in a setting equipped to manage such complications. In an industrial or laboratory environment, strict containment procedures are mandatory. Handling the pure API requires the use of specialized personal protective equipment (PPE) and engineering controls (e.g., closed systems, glove boxes) to prevent any occupational exposure through inhalation, skin contact, or ingestion, as it poses significant health risks. It is for use only in finished, professionally administered dosage forms.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.