Top Quality 100% Purity of ETHYLENE CAS No.: 74-85-1

VINYL CHLORIDE

vinyl chloride cylinder with 2 L ~1.6 kg net;VINYL CHLORIDE, 1X1ML, MEOH, 200UG/ML;VINYLCHLORID ZYLINDER 7 L MIT NETTO;VINYL CHLORIDE, 1X1ML, MEOH 2000UG/ML;VINYL CHLORIDE, 99.5+%;VINYL CHLORIDE 200UG ML IN METHANOL;vinyl chloride solution;acetylene chloride

75-01-4

C2H3Cl

BZHJMEDXRYGGRV-UHFFFAOYSA-N

62.5

62.50

200-831-0

TSCA listed

29032100

Heterocyclic Ring

0

Colorless, liquefied compressed gas with a faint, sweetish odor

1.6

powder

0.911 g/mL at 25 °C(lit.)

-153.8 °C(lit.)

-13.4 °C(lit.)

-78 °F

n20/D1.3700(lit.)

<1.1g/L(25 ºC)

2-8°C

3,428 at 30 °C (quoted, Standen, 1964)

2.21

The mechanisms of toxicity for noncancer effects of VC have not been completely determined.It is hypothesized that VC is metabolized to the reactive metabolites 2-chloroethylene oxide and, subsequently, 2-chloroacetaldehyde via mixed-function oxidases (MFOs), whose activity is primarily concentrated in the liver. The presence of the reactive 2-chloroacetaldehyde results in protein adduction, which interferes with normal cellular function, resulting in cytotoxicity. This is consistent with the progression of effects from hypertrophy to fatty changes, hyperplasia, and necrosis. Indications of binding to proteins such as immunoglobulin G (IgG) in occupationally exposed individuals show immune responses including B-cell proliferation, hyperimmunoglobulinemia, and complement activation and increased circulating immune complexes. It has been hypothesized that cardiac arrhythmia reported after VC exposure may result from sensitization of the heart to circulatory catecholamines, as occurs with other halogenated hydrocarbons.VC is a known human and animal carcinogen including both increased incidence of hepatic angiosarcomas and hepatotoxicity. It is thought that the mechanism for these liver effects is that VC is metabolized by MFO to form an epoxide intermediate, 2-chloroethylene oxide, which rearranges to form 2-chloroacetaldehyde. These reactive metabolites are transported from parenchymal cells to the nonparenchymal cells forming four primary DNA adducts which produce base–pair transitions during transcription and DNA cross-links. Such mutations can result in the mutation of ras oncogenes and the p53 tumor suppressor gene which are found in VC-exposed individuals.The metabolism of VC to highly reactive metabolites, the observance of DNA adduction in mechanistic studies, and the observed carcinogenicity resulting from a single, high-level inhalation exposure in animals suggest that the primary mechanism of VC carcinogenicity involves direct DNA interactions rather than secondary responses to cytotoxicity.

Open flame, flammable by heat; burning produces toxic chloride fumes

vol% in air: 3.63

Ethereal odor

1.50, 1.68, 2.17, 2.65, and 2.8 at 10, 15, 20, 25, and 30 °C, respectively (EPICS, Ashworth et al.,1988)

Highly flammable. Forms polymeric peroxides that are explosive [Bretherick 1979. p. 164].

VINYL CHLORIDE is peroxidizable. Forms explosive polymeric peroxides in contact with air (in the presence of any of a variety of catalysts) [Bretherick 1979. p. 164]. Long storage in contact with air increases the concentration of the polyperoxides to hazardous levels [MCA Case History 1551. 1969]. The peroxides may initiate exothermic polymerization of the remaining material [Handling Chemicals Safely 1980.p. 958; Bretherick 1979. p. 160]. Light-sensitive. Many oxidizing agents apparently initiate polymerization (oxides of nitrogen, O2, etc.). May react with very hot water or steam to produce toxic fumes.

2-8°C