Pure NMN Powder Bulk

Product name：β-nicotinamide mononucleotide
Other names: Nicotinamide mononucleotide, NMN
Purity:99.9%
CAS number: 1094-61-7
Appearance: White powder, transparent solution
Annual Supply Capacity: 200MT
Application field: Medical, health care, food
Packing: 25KG/Fiber Drum, Foil bag
Detection method: HPLC
Storage: Keep dry and cool

Product introduction:

NMN is the most direct precursor of NAD* (Coenzyme I), which is converted into NAD+ (Coenzyme I) in human cells. In a variety of cellular metabolic reactions, NAD molecules play an important role and are an important support for cells to maintain vitality. Scientists have discovered that declines in NAD during aging are a major cause of disease and disability, such as hearing and vision loss, cognitive and motor dysfunction, immune deficiencies, arthritis due to dysregulated autoimmune inflammatory responses, metabolic disorders, and cardiovascular disease.

Supplementing NMN is the most effective way to increase NAD+ content in the body, thereby delaying, improving, and preventing various phenotypes related to aging, and helping to maintain healthy body functions. Because the content in food is very small, it cannot be supplemented by food alone, so if you want to increase β-NMN, you need to supplement it directly from the outside world.

As a derivative of vitamin B3, NMN has been widely sold and eaten around the world, and there is no report of adverse reactions in the relevant population. The FDA of the United States uses NMN as a raw material for dietary supplements. Japan includes NMN in the "non-medical list" to allow its use in food production. Canada includes NNIN on the list of natural health products. 

At the same time, NMN raw materials have been registered by INCI, PCPC, the European Union, Japan and the United States for use in cosmetics, and cosmetics added with NMN raw materials have also begun to be sold in various countries. Cosmetics containing NMN raw materials are sold in Japan, the United States, and other countries, as well as in Hong Kong, China.

Chemical name: 3-carbamoyl-1-[5'-phosphate_β_D_ribofuranosyl]pyridine

Molecular weight: 334.22

CAS number: 1094-61-7

EINECS/ELINCS Registration Number: 214-136-5

Molecular formula: ChHsN2O&P

Structural formula:

The role and application of NMN

Function

1. Improve skeletal muscle metabolism

Skeletal muscle accounts for 40 percent of total body weight and is composed of slow-twitch and fast-twitch fiber types that differ in contractile protein composition, oxidative capacity, and substrate preference for ATP production. Slow-twitch fibers exhibit low fatigue, high oxidative capacity, and a preference for fatty acids as substrates for ATP production. Fast-twitch fibers have higher fatigability, higher contractile strength, lower oxidative capacity, and prefer glucose as a substrate for ATP production through anaerobic glycolysis.

A randomized, placebo-controlled, double-blind trial (10 weeks in overweight or obese women with prediabetes) indicated that NMN (at a daily dose of 250 mg) increased muscle insulin sensitivity, muscle insulin signaling, and muscle remodeling.

Conclusion: NMN supplementation may have a positive effect on muscle metabolism, repair and remodeling.

2. Beneficial to liver fibrosis

Liver fibrosis is a response to chronic liver injuries such as alcohol intake, viral hepatitis (hepatitis B and C), autoimmune hepatitis, nonalcoholic fatty liver disease, and cholestatic liver disease. The structure of the liver is disrupted by the presence of fibrous scars, which leads to the loss of liver cells and disturbance of normal liver function, eventually leading to liver failure. Liver fibrosis is a reversible process, and as long as the liver is not in advanced cirrhosis, removing the fibrotic response can help fibrosis resolve.

An animal study pointed out that NMN supplementation can inhibit the activation of hepatic stellate cells in mice and prevent liver fibrosis, which provides a new opportunity for the development of liver fibrosis treatment.

Conclusion: Animal studies have found that NMN supplementation may have a positive effect on inhibiting liver fibrosis.

3. Anti-aging

Telomeres are specific DNA-protein structures found at both ends of each chromosome that protect the genome from nucleolytic degradation, unwanted recombination, repair, and interchromosomal fusion. Therefore, telomeres play a vital role in preserving information in our genome. As a normal cellular process, a small portion of telomeric DNA is lost with each cell division. When telomere length reaches a critical value, cells become senescent or apoptotic. Therefore, telomere length can act as a biological clock to determine the lifespan of a cell and an organism.

An animal study indicated that the NAD+ precursor nicotinamide mononucleotide (NMN) can maintain telomere length, inhibit DNA damage response, and improve mitochondrial function.

Conclusion: Animal studies point out that NMN may slow down aging or improve diseases by stabilizing telomeres, but due to the lack of human studies, further verification is needed

4. Good for blood sugar control

Diabetes is a common chronic disease characterized by hyperglycemia. It comes in two types, summarized as type 1 diabetes and type 2 diabetes. Type 1 diabetes is an autoimmune disease with absolute insulin deficiency that occurs in young adults. Type 2 diabetes is characterized by insulin resistance, hyperinsulinemia, and beta-cell failure.Diabetes mellitus and poorly controlled diabetes are associated with microvascular (retinopathy and nephropathy), macrovascular and nonvascular (neuropathy) complications.

An animal study pointed out that nicotinamide mononucleotide (NMN) can enhance hepatic insulin sensitivity by partially activating SIRT1, restore gene expression related to oxidative stress, inflammatory response and circadian rhythm, and help improve glucose intolerance.

Conclusion: Animal studies indicate that NMN may have a positive effect on diabetic blood sugar control.

Product Specification

Certificates：

Security statement：

Our company guarantees that the goods sent are safe, non-flammable and explosive, and consistent with the declaration. Under normal transportation conditions, all losses caused by the products sent by our company shall be borne by our company.

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