1. What is Phlorizin Powder?
Phlorizin Powder is the glucoside of phloretin, which belongs to dihydrochalcones in flavonoids. Phlorizin is extracted from the root bark, stem, and tender leaves of apple trees and apple fruits, and also exists in trace amounts in plants such as Compositae, Rhododendronaceae, Fabaceae, Fagaceae, Liliaceae, and other plants. Compositae, Rhododendronaceae, and Phlorizin also exist in plants such as legumes, Fagaceae, and Liliaceae, but the content is less.
In recent years, phlorizin has also been found in plants such as litchi peel, Duli leaf, and Cynomorium cynomolgus, and its content is relatively small, but there is a large amount of phlorizin in the sweet tea Duasuike. In general, Malus plants are the main source of phlorizin and can be used as raw materials for extracting phloridzin. Apple branches, leaves, bark, etc., contain a large amount of phlorizin.
| Melting point: 113-114ºC |
Solubility: slightly soluble in water, easily soluble in ethanol |
Molecular formula: C21H24O10 |
Molecular weight: 436.41 |
EINECS/ELINCS Registration Number: 200-487-1 |
Structural formula: |
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2. Certificate Of Analysis (COA)
| Product Name | Phlorizin | CAS No. | 60-81-1 |
Botanical Source | Malus pumila Mill. | Plant Part | Branch |
ITEM | SPECIFICATION | RESULT | TEST METHOD |
Physical Description |
Appearance | Off White Powder | Conforms | Visual |
Odor | Characteristic | Conforms | Organoleptic |
Taste | Characteristic | Conforms | Olfactory |
Particle size | 95% passes through an 80 mesh sieve | Conforms | CP2015 |
Chemical Tests |
Assay(on dry basis) | ≥98.0% | 98.16% | HPLC |
Loss on drying | ≤8.0% | 6.56% | CP2020 (105 oC, 3 h) |
Ash | ≤1.0 % | 0.06% | CP2020 (600 oC, 4 h) |
Heavy Metals | ≤10 ppm | Conforms | CP2020 |
Lead (Pb) | ≤2 ppm | Conforms | CP2020(AAS) |
Arsenic (As) | ≤2 ppm | Conforms | CP2020(AAS) |
Cadmium (Cd) | ≤1 ppm | Conforms | CP2020(AAS) |
Mercury (Hg) | ≤1 ppm | Conforms | CP2020(AAS) |
Microbiology Control |
Aerobic bacterial count | ≤1,000 cfu/g | Conforms | CP2020 |
Total Yeast & Mold | ≤100 cfu/g | Conforms | CP2020 |
Escherichia coli. | Negative | Conforms | CP2020 |
Salmonella | Negative | Conforms | CP2020 |
Conclusion | Conforms to specification |
Storage: | Store in tightly sealed, preferably full containers, in a cool, dry, and well-ventilated area. |
Shelf Life | 24 months when properly stored. |
Status: | Non-irradiation; Non-GMO; No Carrier; Halal & Kosher certified. |
3. What is the Process Flow Diagram?
The industrial extraction and purification of phlorizin is a multi-step precision process, with the core goal of maximizing its biological activity and removing impurities while ensuring high yields.
4. Is Phlorizin Effective? How Does It Work?
| ▲Hypoglycemic effect Diabetes is a major disease that threatens human health. The typical symptom of diabetes is hyperglycemia. At present, the main drugs for treating diabetes include traditional sulfonylureas, biguanides, and some new hypoglycemic drugs such as rosiglitazone and pioglitazone.[1,3] Most of its mechanism of action is to promote insulin secretion or increase insulin sensitivity. A large number of existing studies have shown that phlorizin has the effect of lowering fasting blood sugar, and the mechanism of phloridzin lowering blood sugar is to competitively inhibit the transport of glucose molecules by glucose transporters (SGLTs and GLUTs).[4]
▲Antioxidant effect Phlorizin Powder has a significant protective effect on Drosophila oxidative damage caused by a high-fat diet, enhances the activity of SOD and CChemicalbookAT, can significantly prolong the lifespan of Drosophila, and has a strong antioxidant effect.[2]
▲Physiological relevance to plants Phlorizin Powder is closely related to physiological phenomena such as plant growth and development, and stress resistance. It can resist a variety of pathogenic bacteria, including apple scabs, fire blight, and so on. However, it can inhibit the growth of some plants. Low concentrations of phlorizin can promote the growth of Pingyi sweet tea seedlings, but excessive concentrations will cause obstacles to planting and replanting. Phlorizin can promote the regeneration of papaya embryos, especially root growth. Therefore, when it is used as a plant growth regulator, its dosage is an important consideration.
▲ In addition to hypoglycemic, antioxidant, and other biological activities, phlorizin has anti-inflammatory and anti-cancer effects. |
5. What Are the Applications of Phlorizin?
| Phlorizin can lower blood sugar, has anti-tumor, anti-allergic, and antioxidant activities, and has potential utilization value in the food, beauty, and healthcare products industries. |
 ▲ Food Phlorizin Powder has been approved as a food additive. It is a characteristic phenolic substance in apples. Due to problems such as species and origin, the content of phlorizin in different apples varies greatly. Therefore, its content can be used as an indicator to distinguish the origin and quality of apple juice. Phloridin can promote the absorption and utilization of genistein (which inhibits the growth and metastasis of tumor cells), and the development of functional foods rich in phlorizin and genistein has broad market prospects in cancer prevention and treatment. It is a very sweet natural sweetener that can be used as a sugar substitute for diabetics with a sweet tooth. It is oxidized by polyphenol oxidase to produce a bright yellow dye. This dye has strong water solubility and can be used in the food processing industry to replace artificial dyes and avoid the toxic effects of artificial synthetic pigments. Whether it is used as a food additive or functional food, it has potential application value.
▲Medicine Since phlorizin is easily hydrolyzed in the human body to form phlorizin, and the absorption rate of phlorizin in the small intestine is low, phlorizin and other compounds are often designed as polymers for drug development.
▲The antioxidant activity and anti-aging function of cosmetic phlorizin have been confirmed by modern scientific research. Phlorizin, the hydrolyzed product of phlorizin, can competitively inhibit the activity of tyrosinase and interfere with the synthesis of melanin, and its whitening effect is better than many whitening products on the market.
APPCHEM has been working in the plant extraction industry since 2006. APPCHEM has obtained most of the professional certificates in the industry and insists on international standards of production. We have won a lot of awards for our strong creativity and for our R&D strengthening. |
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