99% Pharmacy Grade GSK1349572 Power GMP With Best Price Fast Delivery

GSK1349572 More Info

GSK1349572, now approved and known as Dolutegravir, is a second-generation integrase strand transfer inhibitor (INSTI) developed for the treatment of HIV-1 infection. It was designed to overcome the limitations of first-generation INSTIs, such as raltegravir and elvitegravir, by providing a higher genetic barrier to resistance and a more favorable pharmacokinetic profile. Its molecular structure allows for tight, stable binding to the viral integrase enzyme, effectively blocking the strand transfer step that is critical for the HIV virus to integrate its genetic material into the host cell's DNA. A key feature of its design is its ability to remain bound to the integrase enzyme for a prolonged period, which contributes to its potent and sustained antiviral activity and its once-daily dosing regimen.

Uses and Applications

The primary application of Dolutegravir is as a cornerstone agent in combination antiretroviral therapy (cART) for both treatment-naïve and treatment-experienced adults and children with HIV-1 infection. It is a key component in several single-tablet regimens (STRs), significantly simplifying treatment and improving patient adherence. It is also approved for use in specific populations, such as women of childbearing potential and individuals with co-infections like hepatitis B, though with specific guidance. Beyond its established use, it is investigated in novel applications such as long-acting injectable formulations and for HIV pre-exposure prophylaxis (PrEP). Its use has become a standard of care in many national and international HIV treatment guidelines.

Application Market

The market for Dolutegravir is a major segment within the global antiretroviral pharmaceutical market. It is a high-volume, essential medicine distributed globally, with a significant presence in both high-income and low-to-middle-income countries. The drug is included in the World Health Organization's (WHO) Model List of Essential Medicines and has been central to public health initiatives, such as the "Treat All" approach. While initially a branded product, the market now includes generic versions, dramatically increasing accessibility, particularly through programs funded by organizations like PEPFAR and The Global Fund. The market is characterized by strong competition among pharmaceutical companies and is heavily influenced by national and international treatment guidelines that recommend it as a first-line therapy.

Important Considerations

The use of Dolutegravir requires awareness of its specific safety profile and potential drug interactions. A well-known consideration is the associated risk of neural tube defects when used at the time of conception and during early pregnancy, necessitating careful discussion and alternative options for women of childbearing potential. Other potential side effects include insomnia, headache, and, less commonly, hypersensitivity reactions and hepatic effects. It has interactions with certain medications, such as metal-containing antacids, certain anticonvulsants, and rifampin, which require dose adjustments or timing separation. In an industrial setting, handling the pure active pharmaceutical ingredient (API) requires standard precautions to prevent occupational exposure. It is a prescription-only medication that must be used as part of a comprehensive HIV management plan under the supervision of a healthcare professional.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.