 Home > Pharmaceutical Intermediates > Cardiovascular Agents > Solifenacin succinate for Sale > Macitentan API - An Endothelin Receptor Antagonist for Pulmonary Arterial Hypertension.

Macitentan API - An Endothelin Receptor Antagonist for Pulmonary Arterial Hypertension. buy - large image1

Macitentan API - An Endothelin Receptor Antagonist for Pulmonary Arterial Hypertension. buy - image1

Macitentan API - An Endothelin Receptor Antagonist for Pulmonary Arterial Hypertension. buy - image2

Macitentan API - An Endothelin Receptor Antagonist for Pulmonary Arterial Hypertension.

Name: Macitentan API - An Endothelin Receptor Antagonist for Pulmonary Arterial Hypertension.
Brand: Tianrui
SKU: pr2511121363
Price: 11 USD
Availability: InStock

3 Inquiries

Unit Price: Get Latest Price 

CAS No.:

242478-38-2

Grade:

Pharmaceutical Grade

Content:

98.5%

Port:

Qingdao

Brand:

Tianrui

Packaging:

Sealed fiber drum

Price valid (until):

2025-11-12

Contact Supplier

 Chat Now

Hefei Tianrui Pharmaceutical Chemical Co., Ltd.

Company Type:

Manufactory

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

15 days

Qualification:

Main Products:

APIs

 Visit Store

Product Description
Seller Information
Inquiry History

Description

About Product

Macitentan (CAS: 441798-33-0) is a high-purity active pharmaceutical ingredient (API) that functions as a dual endothelin receptor antagonist. Specifically developed for the treatment of pulmonary arterial hypertension (PAH), it demonstrates improved efficacy in delaying disease progression. Manufactured by Hefei TianRui Pharmaceutical under cGMP conditions, our Macitentan API guarantees high purity, low impurity profiles, and reliable quality for cardiovascular drug formulations.

Items	Specifications
Product Name	Macitentan
CAS Registry Number	441798-33-0
IUPAC Name	N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide
Molecular Weight	588.27 g/mol
Solubility	It is soluble in DMSO, slightly soluble in methanol, and almost insoluble in water.
Melting Point	118-122°C
Primary Use	Pulmonary Arterial Hypertension (PAH)

Shop Roflumilast API - A Selective PDE4 Inhibitor for COPD Maintenance Treatment.-Detailed Image 1

Shop Roflumilast API - A Selective PDE4 Inhibitor for COPD Maintenance Treatment.-Detailed Image 2

Shop Roflumilast API - A Selective PDE4 Inhibitor for COPD Maintenance Treatment.-Detailed Image 3

Company Profile

Founded: 2014
Focus: High-tech enterprise specializing in the development and industrialization of small-molecule pharmaceutical synthesis technology
Facilities:
- Two workshops (TR1 & TR2) with total capacity ≈ 1000 tons/year
- Reactors: 3000L×15, 2000L×10, and numerous smaller reactors (1000L, 500L, 100L)
- Ultra-low temperature cryogenic reactor (explosion-proof workshop included)
- GMP workshop & clean room
QC Lab Equipment: GC×2, HPLC×3, UV, IR, KF titrator, etc.

About company

Shop Roflumilast API - A Selective PDE4 Inhibitor for COPD Maintenance Treatment.-Detailed Image 7

In 2015, the company developed polypeptide absorbent permeation enhancers: ethyl 8-bromo-octanoate and Carsalam, which is the 1st and only qualified Chinese supplier of Semaglutide to meet the internal control requirements of innovator Novo Nordisk.

In 2020, the company independently developed and optimized 8-bromo-octanoic acid and 6-bromo-caproic acid to become a COVID-19 vaccine carrier manufacturer and supplier to Moderna company, contributing its share to the fight against COVID-19.

In 2022, Tianrui R&D Center and cGMP manufacturing facility was inaugurated and put into operation. And in the same year, polypeptide absorbent permeation enhancers SNAC (Salcaprozate Sodium) has successfully obtained the domestic CDE registration number (F20220000072) and the US FDA registration number (037135), and another batch of innovative APIs and pharmaceutical excipients are under registration and approval.

ECHEMI Editorial Reference

White Solid
Solifenacin succinate is a member of isoquinolines.|A quinuclidine and tetrahydroisoquinoline derivative and selective M3 MUSCARINIC ANTAGONIST. It is used as a UROLOGIC AGENT in the treatment of URINARY INCONTINENCE.

Basic Info

Product Name:

Solifenacin succinate

Other Name:

Butanedioic acid,compd. with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (1:1);2(1H)-Isoquinolinecarboxylic acid,3,4-dihydro-1-phenyl-,(3R)-1-azabicyclo[2.2.2]oct-3-yl ester,(1S)-,butanedioate (1:1);Solifenacin succinate;Vesicare;Vesikur;YM 67905

CAS No.:

242478-38-2

Molecular Formula:

C23H26N2O2.C4H6O4

InChIKeys:

InChIKey=RXZMMZZRUPYENV-VROPFNGYSA-N

Molecular Weight:

480.56

Exact Mass:

480.226037

EC Number:

1592732-453-0

UNII:

KKA5DLD701

HScode:

29339900

Categories:

Cardiovascular Agents

Characteristics

PSA:

107

XLogP3:

3.67650

Density:

1.24g/cm3

Melting Point:

~145°

Boiling Point:

505.5°C at 760 mmHg

Flash Point:

259.5ºC

Refractive Index:

1.648

Vapor Pressure:

2.41E-10mmHg at 25°C

Collision Cross Section:

201 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

See More Solifenacin succinate Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Solifenacin succinate Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
APIs

Location:
No.23,lntersection of Fenglehe Avenue and Leiyang Road, Huagang Town,Feixi County, Hefei, Anhui, China.

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
15 days

Total Annual Revenue:
$50 million-$100 million

Total Employees:
11-50

Year of Establishment:
2014

About TianRui

Hefei TianRui Pharmaceutical Chemical Co., Ltd was founded in 2014 as a high-tech enterprise focused on the development and industrialization of pharmaceutical small molecule synthesis technology. Our workshop and R&D center are located in Hefei HuaGang Provincial Industrial Park, Anhui Province. We are committed to providing professional technical services and commercialization of small molecule specialty APIs, CGMP standard intermediates, and functional pharmaceutical excipients and MRNA vaccine vectors for domestic and overseas well-known pharmaceutical companies.

Main Events

In 2015, the company developed polypeptide absorbent permeation enhancers: ethyl 8-bromo-octanoate and Carsalam, which is the 1st and only qualified Chinese supplier of Semaglutide to meet the internal control requirements of innovator Novo Nordisk.

In 2020, the company independently developed and optimized 8-bromo-octanoic acid and 6-bromo-caproic acid to become a COVID-19 vaccine carrier manufacturer and supplier to Moderna company, contributing its share to the fight against COVID-19.

In 2022, Tianrui R&D Center and cGMP manufacturing facility was inaugurated and put into operation. And in the same year, polypeptide absorbent permeation enhancers SNAC (Salcaprozate Sodium) has successfully obtained the domestic CDE registration number (F20220000072) and the US FDA registration number (037135), and another batch of innovative APIs and pharmaceutical excipients are under registration and approval.

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
Pakistan	SOLIFENACIN	1 MT	Sep 9, 2024
India	SOLIFENACIN SUCCINATE IP/BP	5.00 KG	Oct 9, 2023
Pakistan	SOLIFENACIN SUCCINATE	4 KG	Oct 8, 2023

Post an enquiry for this product

More Choices Find All Products for Sale 

Product Name	Grade / Content	Price	Supplier Name	Details
High Purity Solifenacin Succinate CAS 242478-38-2 for Overactive Bladder API	Pharmaceutical Grade/99.8	$6.5-8/G FOB	Hangzhou Hyper Chemicals Limited	Inquiry
High Quality Medicine Raw Material Solifenacin Succinate CAS No. 242478-38-2	/0.00		SHANDONG LOOK CHEMICAL CO.,LTD	Inquiry
Solifenacin succinate242478-38-2	/		Shandong zhishang chemical Co.,Ltd	Inquiry
Solifenacin Succinate 242478-38-2	Pharmaceutical Grade/99		Chong Da Prostaglandin Fine Chemicals Co., Ltd	Inquiry
Solifenacin succinate	/99.00		HANGZHOU LEAP CHEM CO., LTD.	Inquiry

Macitentan API - An Endothelin Receptor Antagonist for Pulmonary Arterial Hypertension.

Product Description

Seller Information