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TianRui Supplies cGMP Vandetanib API for Advanced Cancer Therapies. buy - large image1

TianRui Supplies cGMP Vandetanib API for Advanced Cancer Therapies. buy - image1

TianRui Supplies cGMP Vandetanib API for Advanced Cancer Therapies. buy - image2

TianRui Supplies cGMP Vandetanib API for Advanced Cancer Therapies.

Name: TianRui Supplies cGMP Vandetanib API for Advanced Cancer Therapies.
Brand: Tianrui
SKU: pr2511131381
Price: 11 USD
Availability: InStock

2 Inquiries

Unit Price: Get Latest Price 

CAS No.:

443913-73-3

Grade:

Pharmaceutical Grade

Content:

98.5%

Port:

Qingdao

Brand:

Tianrui

Packaging:

Sealed fiber drum

Price valid (until):

2025-11-12

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Hefei Tianrui Pharmaceutical Chemical Co., Ltd.

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

APIs

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Product Description
Seller Information
Inquiry History

Description

About Product

Vandetanib (CAS: 443913-73-3) is a high-purity active pharmaceutical ingredient (API) that functions as a multi-targeted tyrosine kinase inhibitor. It specifically targets VEGFR, EGFR, and RET pathways, making it particularly effective for the treatment of medullary thyroid cancer. Manufactured by Hefei TianRui Pharmaceutical under strict cGMP conditions, our Vandetanib API guarantees high purity, excellent stability, and reliable quality for targeted cancer therapies.

Items	Specifications
Product Name	Vandetanib
CAS Registry Number	443913-73-3
IUPAC Name	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
Molecular Weight	475.36 g/mol
Solubility	It is soluble in DMSO, soluble in methanol, and almost insoluble in water.
Primary Use	Medullary thyroid carcinoma Non-small cell lung cancer Other solid tumors

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Company Profile

Founded: 2014
Focus: High-tech enterprise specializing in the development and industrialization of small-molecule pharmaceutical synthesis technology
Facilities:
- Two workshops (TR1 & TR2) with total capacity ≈ 1000 tons/year
- Reactors: 3000L×15, 2000L×10, and numerous smaller reactors (1000L, 500L, 100L)
- Ultra-low temperature cryogenic reactor (explosion-proof workshop included)
- GMP workshop & clean room
QC Lab Equipment: GC×2, HPLC×3, UV, IR, KF titrator, etc.

About company

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In 2015, the company developed polypeptide absorbent permeation enhancers: ethyl 8-bromo-octanoate and Carsalam, which is the 1st and only qualified Chinese supplier of Semaglutide to meet the internal control requirements of innovator Novo Nordisk.

In 2020, the company independently developed and optimized 8-bromo-octanoic acid and 6-bromo-caproic acid to become a COVID-19 vaccine carrier manufacturer and supplier to Moderna company, contributing its share to the fight against COVID-19.

In 2022, Tianrui R&D Center and cGMP manufacturing facility was inaugurated and put into operation. And in the same year, polypeptide absorbent permeation enhancers SNAC (Salcaprozate Sodium) has successfully obtained the domestic CDE registration number (F20220000072) and the US FDA registration number (037135), and another batch of innovative APIs and pharmaceutical excipients are under registration and approval.

Basic Info

Product Name:

Vandetanib

Other Name:

4-Quinazolinamine,N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-;N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine;ZD 6474;Vandetanib;4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline;Zactima;CH 331;Caprelsa;N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine;N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-(N-methylpiperidin-4-ylmethoxy)quinazolin-4-amine;AZD 6474;AZD6474;AZD-6474;338992-00-0;660412-36-2;790713-55-2

CAS No.:

443913-73-3

Molecular Formula:

C22H24BrFN4O2

InChIKeys:

InChIKey=UHTHHESEBZOYNR-UHFFFAOYSA-N

Molecular Weight:

475.35

Exact Mass:

475.35

EC Number:

1806241-263-5

UNII:

YO460OQ37K

NSC Number:

760766|744325

DSSTox ID:

DTXSID1046681

NCI Thesaurus Code:

C2737

ATC Code:

L01XE|L - Antineoplastic and immunomodulating agents

HScode:

2933990090

Categories:

Antineoplastics

Characteristics

PSA:

59.5

XLogP3:

4.9

Appearance:

White solid

Density:

1.4±0.1 g/cm3

Melting Point:

242 °C

Boiling Point:

538°C at 760 mmHg

Flash Point:

279.3℃

Refractive Index:

1.629

Water Solubility:

In water, 330 uM (pH 7.4); approx 650 uM (pH approx 6.5)

Storage Conditions:

-20°C Freezer

Vapor Pressure:

1.86X10-11 mm Hg at 25 deg C (est)

Henrys Law Constant:

Henry's Law constant = 6.14X10-17 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pKa1 = 4.46; pKa2 = 13.80 (est)

Experimental Properties:

Hydroxyl radical reaction rate constant = 3.23X10-10 cu cm/molec-sec at 25 °C (est)

See More Vandetanib Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Reproductive toxicity, Category 1B

Specific target organ toxicity â repeated exposure, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302 Harmful if swallowed H360 May damage fertility or the unborn child H373 May cause damage to organs through prolonged or repeated exposure H410 Very toxic to aquatic life with long lasting effects
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P273 Avoid release to the environment.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell. P391 Collect spillage.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Vandetanib Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
APIs

Location:
No.23,lntersection of Fenglehe Avenue and Leiyang Road, Huagang Town,Feixi County, Hefei, Anhui, China.

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
15

Total Annual Revenue:
$50 million-$100 million

Total Employees:
11-50

Year of Establishment:
2014

About TianRui

Hefei TianRui Pharmaceutical Chemical Co., Ltd was founded in 2014 as a high-tech enterprise focused on the development and industrialization of pharmaceutical small molecule synthesis technology. Our workshop and R&D center are located in Hefei HuaGang Provincial Industrial Park, Anhui Province. We are committed to providing professional technical services and commercialization of small molecule specialty APIs, CGMP standard intermediates, and functional pharmaceutical excipients and MRNA vaccine vectors for domestic and overseas well-known pharmaceutical companies.

Main Events

In 2015, the company developed polypeptide absorbent permeation enhancers: ethyl 8-bromo-octanoate and Carsalam, which is the 1st and only qualified Chinese supplier of Semaglutide to meet the internal control requirements of innovator Novo Nordisk.

In 2020, the company independently developed and optimized 8-bromo-octanoic acid and 6-bromo-caproic acid to become a COVID-19 vaccine carrier manufacturer and supplier to Moderna company, contributing its share to the fight against COVID-19.

In 2022, Tianrui R&D Center and cGMP manufacturing facility was inaugurated and put into operation. And in the same year, polypeptide absorbent permeation enhancers SNAC (Salcaprozate Sodium) has successfully obtained the domestic CDE registration number (F20220000072) and the US FDA registration number (037135), and another batch of innovative APIs and pharmaceutical excipients are under registration and approval.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
Pakistan	Vandetanib	1 KG	Jul 24, 2025
Pakistan	Vandetanib	1 KG	May 27, 2025

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