1. Description
Lactose Free, Chemical properties: Homopurine acid calcium belongs to the category of acyl butyrate calcium chelates, with a molecular structure consisting of a D-configuration 4- (2,4-dihydroxy-3,3-dimethylbutyramide) butyric acid skeleton, which forms a stable hexagonal chelating ring with calcium ions through carboxyl groups. It also contains two hydroxyl groups (- OH) and one amide bond (- CONH -). Chemical properties are stable and not easily dissociated in neutral to weakly acidic environments, avoiding the problem of inorganic calcium easily forming precipitates with other substances. The semi hydrated state can reduce hygroscopicity and extend storage life.
Physical properties: Homopontetic acid calcium is a white to off white crystalline powder at room temperature, odorless and tasteless, with good water solubility. It can quickly dissolve in aqueous systems such as pure water and physiological saline, as well as polar organic solvents such as methanol and ethanol. It is insoluble in non-polar solvents such as ether and petroleum ether. The melting point is about 180-185 ℃ (decomposition), and it is stable when stored under dry, sealed, and dark conditions, avoiding high temperatures and strong acid-base environments.
Source and preparation: Homoptothenic acid calcium is mainly prepared by chemical synthesis, using D-glutamic acid or corresponding amide precursors as raw materials. It undergoes hydroxylation and amidation reactions to generate 4- (2,4-dihydroxy-3,3-dimethylbutyramido) butyric acid, which is then chelated with calcium carbonate (or calcium hydroxide) and crystallized and purified to obtain a hemihydrate product. The production process requires control of the reaction pH and chelation temperature to ensure a chelation rate of ≥ 95% and product purity that meets food or pharmaceutical grade standards.
2. Application
In the field of dietary supplements, Homoptothenic acid calcium, as the core ingredient of high bioavailability calcium supplements, is used to develop formulations such as capsules, tablets, oral liquids, etc., targeting calcium deficient populations (such as adolescents, elderly people, pregnant women), neurological health maintenance populations, and those in need of exercise nutrition. Its chelating structure facilitates intestinal absorption, and the amino acid skeleton can assist in nutritional coordination, making it suitable for daily calcium supplementation, brain function maintenance, post exercise recovery, and other scenarios.
In the fields of medicine and research, Homoptonic acid calcium is used for mechanism research in neurodegenerative diseases (such as Alzheimer's disease, cognitive impairment), osteoporosis, and other areas. In scientific research, cell models (such as neurons and osteoblasts) and animal models are used to explore their effects on neurotransmitter regulation, osteoblast proliferation, and calcium metabolism pathways, providing experimental evidence for the development of intervention drugs for related diseases.
Cosmetics: Homepantothenic acid calcium is added to sensitive skin care products (such as lotion, face cream, repair essence) and maternal and infant care products based on its mildness, moisture retention and skin barrier repair activity. It can regulate the calcium concentration in the stratum corneum of the skin, promote lipid synthesis, enhance skin barrier function, and hydroxyl groups have moisturizing effects, suitable for the care needs of dry and damaged skin.
3. Main Efficacy
Efficient Calcium Supplementation Effect: Homopurine acid calcium, as a chelated form of calcium, has a unique molecular structure that can avoid interference from anions such as oxalate and phosphate in the gastrointestinal tract. It is actively absorbed through amino acid transporters in the intestinal mucosa, with a significantly higher absorption rate than inorganic calcium such as calcium carbonate and calcium phosphate. Calcium is involved in physiological processes such as bone mineralization, muscle contraction, and nerve signal transmission, and can effectively improve problems such as osteoporosis and muscle spasms caused by calcium deficiency.
Neuroprotective and cognitive support effects: The amide based butyric acid backbone in Homopontinic acid calcium molecules can pass through the blood-brain barrier as a neurotransmitter regulator, enhancing the inhibitory effect of the gamma aminobutyric acid (GABA) system, relieving neural excitation, and improving sleep quality; Simultaneously promoting the expression of neurotrophic factors (such as BDNF) in the brain, protecting neuronal mitochondrial function, delaying neuronal aging, and potentially assisting in the maintenance of cognitive function.
Skin barrier repair and moisturizing effects: The calcium ions of Homoptonic acid calcium can act as "signaling molecules" for skin barrier function, promoting the synthesis and arrangement of lipids (such as ceramides) between keratinocytes, enhancing skin barrier integrity, and reducing water loss; The hydroxyl groups in the molecule can form hydrogen bonds with water molecules, forming a moisturizing film on the surface of the skin. At the same time, its mildness can reduce irritation to sensitive skin and alleviate problems such as redness and dryness.
Skeletal Health Enhancement Effect: Homoptothenic acid calcium not only supplements calcium, but its amino acid skeleton can participate in the synthesis of bone collagen, promote osteoblast proliferation and differentiation, inhibit osteoclast activity, thereby improving bone density and reducing the risk of osteoporosis. It is particularly suitable for adolescent bone development and elderly bone health maintenance.
