High Quality Food Grade SAG Powder CAS 3054-47-5 S-Acetyl L-Glutathione S-Acetyl-L-Glutathione

1.  Description

Chemical properties: S-Acetyl-L-glutathione belongs to tripeptide derivatives, and its molecular structure is based on reduced glutathione (glutamate cysteine glycine). The thiol group of the cysteine residue is protected by an acetyl group (- COOH ∝), forming a stable ester bond structure. This modification avoids the problem of free thiol groups being easily oxidized and degraded, greatly improves chemical stability, and enhances molecular lipid solubility, creating conditions for transmembrane absorption.
       Physical properties: S-Acetyl-L-glutathione is a white to off white crystalline powder at room temperature, with no odor or a slight characteristic odor. It has good water solubility and can quickly dissolve in aqueous systems such as pure water and physiological saline, as well as polar organic solvents such as methanol and ethanol. It is insoluble in non-polar solvents such as ethyl ether and petroleum ether. It can be stored for a long time under dark, sealed, and dry conditions, and attention should be paid to preventing hydrolysis in high temperature or strong alkaline environments.
       Source and preparation: S-Acetyl-L-glutathione is mainly prepared by chemical synthesis, using high-purity reduced glutathione as raw material, reacting with acetylation reagents (such as acetic anhydride) under mild conditions, purifying and crystallizing to obtain the target product. The production process requires precise control of the degree of acetylation and reaction conditions to ensure that the product purity is ≥ 98% and the intact biologically active structure is retained.

2.  Application

       In the fields of medicine and research, S-Acetyl-L-glutathione is an upgraded form of glutathione supplement used for research and adjuvant therapy of oxidative stress-related diseases such as liver disease, neurodegenerative diseases, and cardiovascular diseases. In scientific research, cell and animal models are used to explore their regulatory effects on intracellular redox balance, mitochondrial function, and inflammatory pathways, providing experimental evidence for disease intervention.
      Cosmetics: S-Acetyl-L-glutathione is used in anti-aging skin care products (such as essence liquid, face cream and facial mask) based on its high stability and transdermal property. Its fat solubility advantage makes it easy to penetrate the stratum corneum of the skin, release activity in the dermis layer, exert antioxidant and repairing effects, and meet the anti-aging and brightening needs of mature and dull skin.
       In the field of dietary supplements, S-Acetyl-L-glutathione, as a highly efficient precursor of glutathione, is used to develop dietary supplements such as capsules, tablets, and oral liquids, targeting people who are concerned about liver health, anti-aging and immune enhancement. After oral administration, it can resist the degradation of gastrointestinal digestive enzymes, be efficiently absorbed by the human body, and converted into reduced glutathione, with significantly higher bioavailability than ordinary glutathione.

3. Main Efficacy

 Efficient antioxidant and anti-aging effects: After S-Acetyl-L-glutathione enters the body, the acetyl group is shed under the action of esterase, releasing the active thiol group (- SH) of reduced glutathione, which can directly eliminate oxidative substances such as reactive oxygen species (ROS) and lipid free radicals, and inhibit lipid peroxidation; Simultaneously maintaining the balance of intracellular glutathione redox cycle, reducing oxidative stress damage to cells, and delaying cell and body aging.
        Liver protection and detoxification effects: Reduced glutathione converted from S-Acetyl-L-glutathione combines with toxic substances (such as drug metabolites, heavy metal ions, and alcohol metabolism intermediates) in the liver to form water-soluble complexes that are excreted from the body, reducing the damage of toxins to liver cells; Simultaneously activate the liver detoxification enzyme system, accelerate the detoxification process, and promote the repair of damaged liver cells.
         Skin repair and brightening effects: S-Acetyl-L-glutathione is absorbed by the skin and exerts antioxidant effects in the dermis layer, reducing oxidative damage caused by ultraviolet radiation and pollutants; Simultaneously inhibiting tyrosinase activity, reducing melanin synthesis, fading pigmentation, brightening skin tone, promoting collagen fiber synthesis, enhancing skin barrier function, and improving skin delicacy and firmness.
     Advantages of high bioavailability: Acetylation modification not only enhances stability, but also increases lipid solubility, allowing it to be efficiently absorbed through the lipid transport channels of intestinal epithelial cells, avoiding the problem of reduced glutathione being easily degraded by gastric acid and digestive enzymes when taken orally. The oral absorption efficiency can reach 3-5 times that of ordinary glutathione, which can quickly increase glutathione levels in the body.