50000u/mL Hyaluronidase High Quality and best Price CAS 37326-33-3 Pharmacy Grade

Hyaluronidase More Info

Hyaluronidase refers to a family of enzymes that catalyze the hydrolysis of hyaluronic acid, a major component of the extracellular matrix. The specific form used therapeutically, often derived from mammalian sources, is associated with the CAS Registry Number 37326-33-3. This enzyme functions by breaking the glycosidic bonds in hyaluronic acid, a polysaccharide that forms a viscous, gel-like barrier in tissues. By depolymerizing this complex polymer, hyaluronidase temporarily reduces the viscosity of the interstitial fluid, thereby increasing tissue permeability.

The primary mechanism of action is the enzymatic degradation of hyaluronic acid, which is a key constituent of the ground substance that binds cells together. This action lowers the structural resistance within tissues, creating channels for the diffusion of fluids and other molecules. The effect is often described as "spreading," as it promotes the dispersion and absorption of substances that have been injected into or accumulated within the tissue. This process is reversible, as the body continuously synthesizes new hyaluronic acid to restore the normal interstitial matrix over a period of 24 to 48 hours.

The clinical applications of hyaluronidase are diverse and leverage its ability to enhance the diffusion of other injected drugs or fluids. It is commonly used as an adjuvant to increase the absorption and dispersion of other injected therapeutics, such as local anesthetics or antibiotics. A major application is in ophthalic surgery, where it is injected to facilitate local anesthesia. It is also critically important as an antidote to manage extravasation of certain damaging intravenous fluids, like vinca alkaloids or hyperosmolar solutions, by promoting their rapid dispersal away from the site of infiltration.

This therapeutic agent is supplied as a sterile, lyophilized powder that is reconstituted with a specific solution, most commonly normal saline, immediately before use. The reconstituted solution is then injected subcutaneously or intradermally at the target site. Dosage is measured in international units, and the amount administered varies significantly depending on the specific clinical indication, ranging from a small number of units for enhancing local anesthesia to much higher doses for managing extravasation injuries.

The safety profile of hyaluronidase is generally favorable, with adverse effects being uncommon and typically mild. The most frequently reported reactions are localized to the injection site and may include erythema, swelling, or transient pain. As a protein of animal origin, there is a very low risk of allergic reactions or anaphylaxis, particularly in individuals with a history of sensitivity to animal-derived proteins. Its use is contraindicated in areas of active infection or malignancy due to the potential for spreading the infectious or neoplastic process.

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We can send you a samll free sample, and you only need to pay for the shipping cost.

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For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

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Suitable for more than 50kg 
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Suitable for more than 500kg      
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For sample orders: 
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2. Packaging photo
3. COA, MSDS, etc
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5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

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