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Acetyl ketene 674-82-8

Name: Acetyl ketene 674-82-8
Brand: Orient
SKU: pr2511251328
Price: 2 USD
Availability: InStock

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CAS No.:

674-82-8

Grade:

Industrial Grade

Content:

99%

Port:

shanghai

Brand:

Orient

Packaging:

25kg/bag,500kg/bag, customized

Price valid (until):

2025-12-25

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
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Inquiry History

Description

Acetyl ketene Basic information

Product Name:	Acetyl ketene
Synonyms:	3-buteno-beta-lactone;3-Butenoic acid, 3-hydroxy-, beta-lactone;3-hydroxy-3-butenoicacibeta-lactone;4-methylene-2-oxetanon;Diketen;diketene,inhibited;Ethenone, dimer;ethenone,dimer
CAS:	674-82-8
MF:	C4H4O2
MW:	84.07
EINECS:	211-617-1
Product Categories:	Aromatic amine products;Pharmaceutical Intermediates
Mol File:	674-82-8.mol

Acetyl ketene Chemical Properties

Melting point	-7.5°C
Boiling point	69-70 °C100 mm Hg(lit.)
density	1.09 g/mL at 25 °C(lit.)
vapor density	2.9 (vs air)
vapor pressure	7.9 mm Hg ( 20 °C)
refractive index	n20/D 1.439(lit.)
Fp	95 °F
storage temp.	2-8°C
InChI	InChI=1S/C4H4O2/c1-3-2-4(5)6-3/h1-2H2
InChIKey	WASQWSOJHCZDFK-UHFFFAOYSA-N
SMILES	O1C(=C)CC1=O
CAS DataBase Reference	674-82-8(CAS DataBase Reference)
NIST Chemistry Reference	2-Oxetanone, 4-methylene-(674-82-8)
EPA Substance Registry System	Diketene (674-82-8)

Safety Information

Hazard Codes	Xn
Risk Statements	10-20-40-36/37/38
Safety Statements	3-36/37-33-24/25-23-16-26
RIDADR	UN 2929 6.1/PG 2
WGK Germany	2
RTECS	RQ8225000
F	19-21-27
HazardClass	6.1(a)
PackingGroup	I
Hazardous Substances Data	674-82-8(Hazardous Substances Data)
IDLA	7.6 ppm

Acetyl ketene Usage And Synthesis

Chemical Properties	Diketene [674-82-8], C4H4O2, Mr 84.04, is a colorless liquid when pure; it possesses a pungent odor and is a strong lachrymator. The human odor perception threshold is 0.019 mg/m3. Crude diketene obtained from the dimerization of ketene is often used without further purification; it is dark brown and contains up to 10 % higher ketene polymers.
Uses	Diketene is used as a reactant in the manufacture of paper and control of its sizing. In addition its used in the preparation of potent and selective inhibitor of histone methyltransferase EZH2 in the treatment of B-Cell lymphomas.
General Description	A colorless liquid with a disagreeable odor. Slightly less dense than water. Flash point 90°F. Irritates skin and eyes. Used to make paints and pharmaceuticals.
Air & Water Reactions	Highly flammable. Slightly soluble in water.
Reactivity Profile	DIKETENE is a very reactive dimer, Acetyl ketene may undergo a spontaneous decomposition followed by explosion or ignition [Vervalin, 1973, p.86]. In the presence of bases, amines, mineral acids or Lewis acids a violent polymerization will occur, accompanied by gas evolution [Zdenek, F. et al., Czech Pat. 156 584, 1975].
Health Hazard	TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard	HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. May polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Chemical Reactivity	Diketene is a reactive, versatile compound, which cannot be stored indefinitely, even in the presence of stabilizing agents such as sulfates, borates, or sulfur. On standing for several days or weeks, it turns yellow and then brown. Glass vessels are not recommended for storage because the basicity of glass promotes decomposition: stainless steel or aluminum is preferred. Diketene reactions proceed mainly by ring opening and are highly exothermic. Traces of base or strong acid can lead to violent, almost explosive polymerization, and due care should be exercised when handling diketene.
Solubility in organics	Diketene is miscible with acetic anhydride, with many ketones and esters (e.g., acetone, methyl acetate, ethyl acetate, butyl acetate) with diethyl ether, tetrahydrofuran, chlorinated hydrocarbons, acetonitrile, and toluene. Furthermore, contrary to most literature reports, it is slightly soluble in aliphatic hydrocarbons such as hexane (ca. 12.5 wt % at 23℃), octane, cyclohexane, and methylcyclohexane. It is very slightly soluble in water, in which it decomposes slowly.

Acetyl ketene Preparation Products And Raw materials

Raw materials

Acetic acid-->Acetone-->Polyethylene-->Butyl acetate-->ketene-->Triethyl phosphate-->Polymerization inhibitor

Preparation Products

Acetic anhydride-->Ethyl acetoacetate-->Chloroacetyl chloride-->5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one-->Methyl acetoacetate-->Acetoacetanilide-->Sorbic acid-->Pigment Red 122-->Quizalofop-p-ethyl-->Dehydroacetic acid-->Butyric anhydride-->2-Acetylbutyrolactone-->Acesulfame-->Imazethapyr-->Ethyl 4-chloroacetoacetate-->Acesulfame potassium-->o-Acetoacetaniside-->Olaquindox-->tert-Butyl acetoacetate-->N,N-Diethylacetoacetamide-->Manidipine-->Amitriptyline hydrochloride-->Seedavay(Uniroyal)-->N-Methylacetoacetamide-->Isobutyl acetoacetate-->2'-Chloroacetoacetanilide-->PHOSPHAMIDON-->Acetoacetamide-->2'-Methylacetoacetanilide-->ACETOACETIC ACID N-BUTYL ESTER-->22(S),23(S)-Homobrassinolide-->2,6-HEPTANEDIONE-->5-CHLORO-6 B,19-EPOXY-5A -ANDROTANE-3,17-DIONE-->N-Acetyl-N-(4-chloro-2-nitrophenyl)acetamide-->Dichlorosulfophenyl-3-methylpyrazolone-->FEMA 2510-->N,N'-(3,3'-Dimethyl-4,4'-biphenyldiyl)bis(3-oxobutanamide)-->4'-Methoxyacetoacetanilide

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer, .

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

Diketene

Other Name:

2-Oxetanone,4-methylene-;3-Butenoic acid,3-hydroxy-,β-lactone;Diketene;Ethenone,dimer;4-Methylene-2-oxetanone;Ketene dimer;NSC 93783;2130-41-8;6144-29-2

CAS No.:

674-82-8

Molecular Formula:

C4H4O2

InChIKeys:

InChIKey=WASQWSOJHCZDFK-UHFFFAOYSA-N

Molecular Weight:

84.07340

Exact Mass:

84.07

EC Number:

211-617-1

UNII:

0DZ97C3Z7D

ICSC Number:

1280

NSC Number:

93783

UN Number:

2521

DSSTox ID:

DTXSID9027289

Color/Form:

Colorless liquid; turns brownish-yellow upon standing at room temperature|Colorless liquid when pure|Light colored liquid

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

26.30000

XLogP3:

0.44700

Appearance:

COLOURLESS LIQUID

Density:

1.0897 g/cm³

Melting Point:

-6.5 °C

Boiling Point:

127.4 °C

Flash Point:

Refractive Index:

1.439

Water Solubility:

Solubility in water: reaction

Storage Conditions:

2-8ºC

Vapor Pressure:

7.9 mm Hg ( 20 °C)

Vapor Density:

2.9 (vs air)

Explosive limit:

Explosive limits , vol% in air: 2-11.7

Odor:

Pungent odor

Henrys Law Constant:

Henry's Law constant = 6.07X10-4 atm-cu m/mol at 25 °C (est)

Experimental Properties:

BP: 126-127 °C with slight decomposition; 69-71 °C at 100 mm Hg. MP: -7.5 °C|Readily polymerizes on standing|Specific gravity: 1.0939 at 18 °C/4 °C; 1.0905 at 23 °C/4 °C|Specific gravity: 1.09471 at 20 °C/4 °C; 1.088754 at 25 °C/4 °C|Decomposes in water, can react with oxidizing materials|There is no known inhibitor /of polymerization/. Polymerization of uncontaminated diketene is negligible if kept at or near 0 °C.|For more Other Experimental Properties (Complete) data for Acetyl ketene (9 total), please visit the HSDB record page.

Air and Water Reactions:

Highly flammable. Slightly soluble in water.

Reactive Group:

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

Reactivity Alerts:

Highly Flammable

Reactivity Profile:

DIKETENE is a very reactive dimer, it may undergo a spontaneous decomposition followed by explosion or ignition [Vervalin, 1973, p.86]. In the presence of bases, amines, mineral acids or Lewis acids a violent polymerization will occur, accompanied by gas evolution [Zdenek, F. et al., Czech Pat. 156 584, 1975].

Autoignition Temperature:

590 °F (310 °C)|275 °C

Heat of Vaporization:

42.89 kJ/mol at 25 °C

Critical Temperature & Pressure:

Critical temperature: 310 °C (583.16 K); critical pressure: 5.47 MPa

See More Diketene Properties 

Hazard Identification

Classification of the substance or mixture

Flammable liquids, Category 3

Acute toxicity - Category 4, Inhalation

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H226 Flammable liquid and vapour H332 Harmful if inhaled
Prevention	P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P317 Get medical help.
Storage	P403+P235 Store in a well-ventilated place. Keep cool.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames, NO sparks and NO smoking. Above 33Â°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Fireproof. Separated from acids, bases and food and feedstuffs. Cooled. Dry. Store only if stabilized.Store at 32 deg F (0 deg C) in a standard flammable liquids storage warehouse, room, or cabinet. Special vented containers may be required. Separate from oxidizing materials, acids, and alkalies.

See More Diketene Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
Russia	Acetyl ketene	10 KG	Nov 25, 2024
Russia	4-Methyl-2H-oxet-2-one	10 KG	Nov 26, 2024

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Acetyl ketene 674-82-8

Product Description

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