99% Tofacitinib Pharmaceutical Grade CAS 477600-75-2 White Raw Power with Best Price

Tofacitinib More Info

Tofacitinib is a small molecule pharmaceutical agent classified as a Janus kinase inhibitor, with the CAS Registry Number 477600-75-2. Its chemical structure is designed to fit competitively into the ATP-binding site of the catalytic domain of specific JAK enzymes. This synthetic compound is a pivotal member of a newer class of targeted immunomodulatory drugs, providing an oral alternative to biologic therapies for various inflammatory conditions. It is typically formulated as a citrate salt to improve its solubility and bioavailability for pharmaceutical use.

The primary mechanism of action for tofacitinib is the potent inhibition of the Janus kinase family of enzymes, particularly JAK1 and JAK3. By blocking these intracellular enzymes, it interferes with the signaling pathway of multiple cytokines, including interleukins and interferons, which rely on the JAK-STAT signaling cascade to exert their pro-inflammatory effects. This disruption prevents the activation of gene transcription involved in immune cell proliferation and inflammatory responses, thereby dampening the underlying autoimmune process in various diseases.

The clinical applications of tofacitinib are broad and primarily focused on autoimmune disorders. It is approved for the treatment of moderate to severe rheumatoid arthritis, often after an inadequate response to methotrexate. Additionally, it is used for active psoriatic arthritis, moderate to severe ulcerative colitis, and active polyarticular course juvenile idiopathic arthritis. Its efficacy in these conditions stems from its ability to systemically reduce inflammation and halt the progression of joint damage and other disease-specific pathologies.

This medication is administered orally in the form of immediate-release or extended-release tablets, providing significant convenience for patients compared to injectable biologic agents. Dosing is tailored to the specific condition being treated, with options for once or twice-daily administration. The drug demonstrates rapid absorption and a relatively short half-life, necessitating consistent dosing to maintain therapeutic effect. Its pharmacokinetics allow for predictable systemic exposure, which is managed through standardized dosing regimens.

The safety profile of tofacitinib includes several important considerations common to potent immunomodulators. An increased risk of serious infections, including tuberculosis and opportunistic pathogens, is a significant concern and requires screening and monitoring. Other notable risks include herpes zoster reactivation, lymphomas and other malignancies, thrombosis, and laboratory abnormalities such as neutropenia, anemia, and elevated liver enzymes and lipid levels. These risks necessitate careful patient selection and ongoing vigilance, including regular blood tests, throughout the treatment course.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

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HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.