Skin Whitening Injection Peptides Snap-8 10mg/Vial Acetyl Octapeptide-1 Lyophilized Powder CAS: 868844-74-0

1.  Description

    Chemical Properties: Acetyl octapeptide-1 is a linear octapeptide compound with the core amino acid sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂. Features N-terminal acetylation (-Ac-) and C-terminal amidation (-NH₂), with this dual-modified structure significantly enhancing resistance to peptidase hydrolysis. Its half-life is extended by 4-5 times compared to unmodified peptides. Chemically stable, it resists degradation within a pH range of 4.0-7.5. It exhibits excellent compatibility with mainstream anti-aging ingredients such as retinol, boswellia, and hyaluronic acid, with no risk of oxidative discoloration or inactivation. Its primary target is the SNARE complex at the neuromuscular junction.

    Physical Properties: Acetyl octapeptide-1 appears as a white to off-white crystalline powder at room temperature, odorless and tasteless. It exhibits excellent water solubility (solubility ≥80 mg/mL), dissolving rapidly in aqueous/alcoholic systems like purified water, propylene glycol, and glycerin. It is slightly soluble in ethanol and insoluble in non-polar solvents such as petroleum ether. Store at 2-8°C in a dry, sealed container protected from light. Avoid exposure to high temperatures (>45°C) and strong oxidizing agents. Cosmetic-grade product purity ≥98% (HPLC detection), impurities ≤1.0%, free amino acid impurities absent.

    Source and Preparation: Acetyl octapeptide-1 has no natural occurrence and is precisely synthesized via solid-phase peptide synthesis. Using high-purity L-type amino acids as raw materials, the target sequence is constructed through multiple reactions including condensation, deprotection, and peptide chain assembly. The final high-purity product is obtained via high-performance liquid chromatography (HPLC) purification. The synthesis process strictly controls reaction temperature and feed ratios to ensure peptide chain structural integrity and biological activity.

2.  Application

     High-end anti-aging skincare (core application): Acetyl octapeptide-1, as a “botulinum toxin-like” anti-wrinkle core ingredient, is widely incorporated into anti-wrinkle serums, firming creams, eye serums, neck creams, and similar products. It targets dynamic expression lines such as forehead wrinkles, crow's feet, and nasolabial folds. Suitable for early-aging skin (25+) and mature skin (35+), it can be used alone or combined with ingredients like Acetyl Hexapeptide-8 and Conchiolin Peptide to achieve dual improvement for both dynamic and static wrinkles.

    Medical Aesthetics Skincare: Acetyl octapeptide-1 is incorporated into post-Botox injection repair/maintenance products to prolong wrinkle-reducing effects (clinical data shows a 2-3 week extension) while alleviating post-injection skin stiffness and dryness. It can also be added to post-procedure repair products for photofacials, microneedling, and other aesthetic treatments, supporting skin barrier repair alongside anti-wrinkle benefits.

    Biomedical Research Field: Acetyl octapeptide-1 serves as a research tool in studying skin neuromuscular transmission mechanisms. It is used in fibroblast and skeletal muscle cell model experiments to investigate peptide regulation of neurotransmitter release and muscle contraction. Additionally, it functions as a positive control for anti-wrinkle peptide screening, providing experimental evidence for novel anti-aging peptide development.

3. Main Efficacy

    Targeted improvement of dynamic expression lines: Acetyl octapeptide-1 works by competitively inhibiting the formation of the SNARE complex (soluble N-ethylmaleimide-sensitive receptor attachment protein receptor) at the neuromuscular junction. This blocks the release of acetylcholine from nerve endings to muscle cells, reducing excessive facial muscle contraction and thereby diminishing dynamic expression lines (such as laugh lines and frown lines). Human clinical trials demonstrate that continuous application of 0.05% Acetyl Octapeptide-1 for 28 days reduces crow's feet depth by 21.7% and forehead wrinkle area by 18.9%, achieving efficacy comparable to low-concentration botulinum toxin without muscle stiffness side effects.

    Synergistic Improvement of Static Wrinkles and Skin Firmness: Beyond inhibiting dynamic wrinkles, Acetyl octapeptide-1 activates skin fibroblasts to promote synthesis of Type I and III collagen and elastin, enhancing dermal support to gradually improve static wrinkles caused by collagen loss. It also strengthens the dermal-epidermal junction (DEJ) structural integrity, boosting skin elasticity and firmness for a refined, plump complexion.

    Mild Safety & High Transdermal Penetration: With a molecular weight of only 994.1 Da, acetylation modification elevates its transdermal absorption rate to over 38%, enabling penetration through the stratum corneum to act in the superficial dermis. Non-cytotoxic (MTT assay shows >96% cell viability at concentrations ≤1 mg/mL) and non-sensitizing (negative HRIPT test), suitable for sensitive skin, pregnant women, and other special skin types, avoiding the invasiveness and potential risks associated with botulinum toxin injections.