Resveratrol CAS:501-36-0 C14H12O3

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The company's main products include pharmaceutical intermediates, food additives, essence, spices and plant extracts. The products have passed international certification and are exported to Europe, America, Japan, South Korea and Southeast Asia.

Resveratrol Basic information Resveratrol Benefits and ralting biological activities resveratrol sources plants Resveratrol Extraction Contents determination method Pharmacological effects The synthetic method of resveratrol Solubility Possible Side effects Uses Product Name: Resveratrol Synonyms: TRANS-3,4,5-TRIHYDROXYSTILBENE;TRANS-3,5,4'-STILBENETRIOL;TRANS-RESVERATROL;TRANS-1,2-(3,4',5-TRIHYDROXYDIPHENYL)ETHYLENE;RESVERATROL;RESVERATROLE;3,4',5'-TRIHYDROXY-TRANS-STILBENE;3,4',5-TRIHYDROXY-TRANS-STILBENE CAS: 501-36-0 MF: C14H12O3 MW: 228.24 EINECS: 610-504-8 Product Categories: natural product;Pyridines;Stilbenes (substituted);Miscellaneous;Inhibitors;Caspases/Apoptosis;Antioxidant;Biochemistry;Stilbenes;Natural Plant Extract;Beauty;The group of Polydatin;Intermediates & Fine Chemicals;Pharmaceuticals;Health supplements;Plant extracts;Inhibitor;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;RESVEPURE;plant extract;501-36-0 Mol File: 501-36-0.mol Resveratrol Chemical Properties Melting point  253-255°C Boiling point  449.1±14.0 °C(Predicted) density  1.359±0.06 g/cm3(Predicted) storage temp.  -20°C solubility  Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml). pka 9.22±0.10(Predicted) form  Powder color  Off-white biological source plant root (bushy knotweed) Water Solubility  Soluble in water (3 mg/100mL), ethanol (50 mg/mL), DMSO (16 mg/mL), DMF (~65 mg/mL), PBS (pH 7.2) (~100µg/mL), methanol, and acetone (50 mg/mL). Merck  14,8158 Stability: Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. InChI InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+ InChIKey LUKBXSAWLPMMSZ-OWOJBTEDSA-N SMILES C1(O)=CC(/C=C/C2=CC=C(O)C=C2)=CC(O)=C1 LogP 3.139 (est) CAS DataBase Reference 501-36-0(CAS DataBase Reference) EPA Substance Registry System 1,3-Benzenediol, 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]- (501-36-0) Safety Information Hazard Codes  Xi Risk Statements  37/38-41-36/38-36-43-22 Safety Statements  26-39-37/39-36/37/39 WGK Germany  3 RTECS  CZ8987000 HS Code  29072990 Hazardous Substances Data 501-36-0(Hazardous Substances Data) MSDS Information Resveratrol Usage And Synthesis Resveratrol Benefits and ralting biological activities Much of the research pointing to the benefits have been laboratory or animal-based studies. So far, research on resveratrol's effectiveness in humans has yielded mixed results. Anti-Aging and Anti-Cancer Effects Effects on biotransformation enzymes Inhibition of proliferation and induction of apoptosis Inhibition of tumor invasion and angiogenesis Anti-inflammatory effects Protects Cardiovascular Health Inhibition of vascular cell adhesion molecule (VCAM) expression Inhibition of vascular smooth muscle cell (VSMC) proliferation Stimulation of endolethelial nitric oxide synthase (eNOS) activity Inhibition of platelet activiation and aggregation Helps Protect the Brain and Cognitive/Mental Health Stimulation of neurogenesis and microvessel formation Stimulation of β-amyloid peptide clearance Inhibition of neuroinflammation Reduction of oxidative stress resveratrol sources plants Resveratrol is anthraquinone terpenoids. It mainly comes from rhizome extract of polygonum cuspidatum. Polygonum cuspidatum: Shrubby perennial herb, up to 1 meter or more. Rhizome lying underground, wood brown, section significantly. Stems erect and cylindrical, surface glabrous, scattered with most red spots, hollow. Leaves alternate, broadly ovate to nearly circular, long 7-12cm, width 5-9cm, apex mucronate, base rounded or cuneate; petiole 1-1.5cm sheath care quality, brown, early fall. Flowering is from July to September, and fruiting from September to October. Spring and autumn can be excavated, cut and dried. Polygonum cuspidatum is born in the valley, creek or shore. Resveratrol Extraction Polygonum cuspidatum is the rhizome of polygonaceae polygonum cuspidatum. Polygonum cuspidatum rhizome contains free anthraquinone and anthraquinone glycosides, whch mainly are emodin ether, rhubarb phenol, anthracene glycosides A and B, etc. It also contains resveratrol glycosides, polydatin, protocatechuic acid, dextrose catechin, tree anthrone-8-glucosidecassia, β-sitosterol glucoside and glucose, rhamnose, ginger candy, amino acids, tannin and copper, iron, manganese, zinc, potassium and potassium salts, etc. Figure 1 is Polygonum cuspidatum plant Resveratrol (Res) is a non-flavonoid polyphenol compound. It is considered as a phytoalexin, which is generated when the plant is attacked by pathogenic, or in the poor environment. It is mainly found in grapes, giant knotweed, peanuts, mulberry, pine, Gnetum, Korea Huaifrom 12 families and 31 genera of 72 species of plants. Extraction of the natural plant: polygonum cuspidatum is used as raw material, extracted, extracted resveratrol crude, and then purified. Crude extraction technologies include organic solvent extraction method, the new method of alkaline extraction and enzymatic extraction method. New methods like microwave-assisted extraction, CO2 supercritical extraction and ultrasonic extraction are also applied. The main purpose of purification is to extract cis-resveratrol and trans-resveratrol and polydatin from raw resveratrol to obtain trans-resveratrol. Common methods of purification are chromatography, silica gel column chromatography, thin-layer chromatography, high performance liquid chromatography and the like. Resveratrol had significant antioxidant activity on animal fats. Sample of 240mg/kg shows the strongest antioxidant activity during the three samples whose concentration of resveratrol is respectively 120 mg/kg, 240mg/kg, 360mg/kg. In antioxidant tests on lard, the antioxidant effect of resveratrol is stronger than polyphenols with same concentration.

First aid measures

General advice Consult a physician. Show this material safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Firefighting measures

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides Nitrogen oxides (NOx) Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.



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