Focusing on innovative research, development, and production in the field of fine chemicals, we prioritize technology, quality, and market orientation. We collaborate with global partners to build a high-tech chemical industry chain and promote sustainable development in the industry.
The company's main products include pharmaceutical intermediates, food additives, essence, spices and plant extracts. The products have passed international certification and are exported to Europe, America, Japan, South Korea and Southeast Asia.
| Product Name: | WS 12 | | Synonyms: | Cooling agent WS12;(1R,2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexane-1-carboxamide;WS 12;(1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide;CyclohexanecarboxaMide, N-(4-Methoxyphenyl)-5-Methyl-2-(1-Methylethyl)-, (1R,2S,5R)-;(2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide;(1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE;Cyclohexanecarboxamide, N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)- | | CAS: | 68489-09-8 | | MF: | C18H27NO2 | | MW: | 289.41 | | EINECS: | 700-232-9 | | Product Categories: |
| | Mol File: | 68489-09-8.mol |  |
| | WS 12 Chemical Properties | | Boiling point | 447.8±28.0 °C(Predicted) | | density | 1.029±0.06 g/cm3(Predicted) | | vapor pressure | 0-0Pa at 20-50℃ | | FEMA | 4681 | (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE | | storage temp. | -20°C | | solubility | DMSO: >20mg/mL | | pka | 14.18±0.70(Predicted) | | form | White to off-white powder. | | color | white to off-white | | Odor | at 100.00 %. cool minty | | Odor Type | minty | | JECFA Number | 2079 | | InChIKey | HNSGVPAAXJJOPQ-XOKHGSTOSA-N | | LogP | 3.95 at 22℃ and pH7.7 | | CAS DataBase Reference | 68489-09-8 | | Hazard Codes | N | | Risk Statements | 50 | | Safety Statements | 53-61 | | RIDADR | UN 3077 9 / PGIII |
| | WS 12 Usage And Synthesis | | Description | WS-12 is an agonist of transient receptor potential melastatin 8 (TRPM8). It induces currents in Xenopus oocytes expressing mouse TRPM8 (EC50 = 12 μM) and is selective for TRPM8 over transient receptor potential vanilloid 1-4 (TRPV1-4) and transient receptor potential ankyrin 1 (TRPA1) at 1 mM. WS-12 (6 nmol, i.c.v.) reduces nocifensive behavior induced by capsaicin in wild-type, but not Trpm8-/-, mice. It induces analgesia in the hot plate test, an effect that can be reversed by the opioid receptor antagonist naloxone, in mice. | | Chemical Properties | WS 12 is a odorless white crystalline solid,mp 178 °C, displaying a strong initial cooling effect and a long-lastingness. It is used particularly is oral care flavors. | | Uses | WS 12 is a potent TRPM8 agonist. | | Trade name | Winsense WS-12 (Renessenz) | | Biological Activity | Potent TRPM8 agonist that acts as a cooling agent (EC 50 = 193 nM). | | Biochem/physiol Actions | WS-12 is a menthol derivative, that shows a specific binding affinity towards TRPM8 (transient receptor potential cation channel subfamily M member 8) receptor. TRPM8 is associated with prostate cancer and thus, WS-12 might be useful in reducing the progression of cancer. | | storage | Store at -20°C | | References | [1] SHERKHELI MA. Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels.[J]. Pakistan journal of pharmaceutical sciences, 2008, 21 4: 370-378.
[2] BOYI LIU . TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain[J]. PAIN?, 2013, 154 10: Pages 2169-2177. DOI: 10.1016/j.pain.2013.06.043 | |
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First aid measures | General advice Consult a physician. Show this material safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. |
Firefighting measures
| Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides Nitrogen oxides (NOx) Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary. |
—— Q&A ——
Q1:Do you provide sample?
A: Yes, we can provide free sample, you only need pay the shipping cost.
Q2: What is the lead time?
A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.
Q3: How can I buy? What is the payment method?
A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,
A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.
