Artemether 71963-77-4

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Artemether Basic information Product Name: Artemether Synonyms: methyl-dihydroartemisinine;[3r-(3r,5as,6s,8as,9r,10r,12s,12ar**)]-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin;ARTEMETHER;ARTHEMETER;Artimether;ArtemetherC16H26O5;cgp56696;dihydroartemisininmethylether CAS: 71963-77-4 MF: C16H26O5 MW: 298.37 EINECS: 663-549-0 Product Categories: Chiral Reagents;Heterocycles;Antimalarial;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;Herb extract;Inhibitor;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;PALUTHER;natural product;API;71963-77-4 Mol File: 71963-77-4.mol Artemether Chemical Properties Melting point  86-88°C alpha  D19.5 +171° (c = 2.59 in CHCl3) Boiling point  359.79°C (rough estimate) density  1.0733 (rough estimate) refractive index  1.6200 (estimate) storage temp.  room temp solubility  DMSO: ≥20mg/mL form  powder color  off-white to light brown Optical Rotation [α]/D +155 to +175°, c = 0.5 in methanol Merck  14,815 InChI InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1 InChIKey SXYIRMFQILZOAM-HVNFFKDJSA-N SMILES O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)[C@@H](OC)O4)O1 Safety Information Hazard Codes  Xn Risk Statements  22 Safety Statements  24/25 WGK Germany  3 RTECS  KD4165000 HS Code  29329930 Hazardous Substances Data 71963-77-4(Hazardous Substances Data) Toxicity LD50 i.m. in mice: 263 mg/kg (China Cooperative Research Group on Qinghaosu) MSDS Information Artemether Usage And Synthesis Description Artemether is an antiparasitic compound and a derivative of artemisinin . It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM, respectively). Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD50) values of 7.1 and 55 mg/kg, respectively. It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg. Formulations containing artemether have been used in the treatment of malaria. Chemical Properties White Solid Uses Derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant. Uses atypical antidepressant, norepinephrine and dopamine reuptake inhibitor, and nicotinic antagonist Uses Artemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when Definition ChEBI: An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falcip rum malaria. General Description Artemisinin (ART) is a natural compound present in Artemisia annua, a traditional Chinese plant. Biochem/physiol Actions Artemether is a methyl ether derivative of artemisinin. It is used against multi-drug resistant strains of the malaria parasite, Plasmodium falciparum, and shows potential in treatment of schistosomiasis. Safety Profile Poison by intramuscular route.Experimental reproductive effects. When heated todecomposition it emits acrid smoke and irritating fumes. target Antifection storage Store at -20°C References [1] S H XIAO  B A C. In vitro and in vivo studies of the effect of artemether on Schistosoma mansoni.[J]. Antimicrobial Agents and Chemotherapy, 1989, 33 9: 1557-1562. DOI: 10.1128/aac.33.9.1557 [2] DYLAN R PILLAI. Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections.[J]. Malaria Journal, 2012: 131. DOI: 10.1186/1475-2875-11-131 [3] M J SHMUKLARSKY. Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo.[J]. American Journal of Tropical Medicine and Hygiene, 1993, 48 3: 377-384. DOI: 10.4269/ajtmh.1993.48.377

First aid measures

General advice Consult a physician. Show this material safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Firefighting measures

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides Nitrogen oxides (NOx) Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.



——  Q&A  ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.