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Afloqualone Dide

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CAS No.:

56287-74-2

Port:

shanghai

Packaging:

25G/Bottle

Price valid (until):

2026-01-15

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Shaanxi Dideu Medichem Co. Ltd

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst

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Product Description
Seller Information

Description

Product Detail

Product Name: Afloqualone
CAS No.: 56287-74-Molecular Formula: C₁₆H₁₄FN₃O
Molecular Weight: 283.Purity: ≥98% (HPLC), customizable
Appearance: White to off-white crystalline powder

Product Overview

Afloqualone is a specialized quinazolinone derivative with significant pharmacological properties as a central muscle relaxant. 7 This high-purity compound exhibits excellent solubility characteristics and stability, making it ideal for pharmaceutical research and development applications. Its unique chemical structure featuring fluorine substitution provides enhanced bioavailability and metabolic stability compared to similar compounds. Afloqualone serves as a valuable research tool for studying neuromuscular disorders and developing novel therapeutic agents targeting muscle spasticity and related conditions.

Main Applications

Pharmaceutical Research & Drug Development
Primary research compound for developing next-generation muscle relaxants and neuromuscular therapeutic agents. Particularly valuable for structure-activity relationship (SAR) studies in central nervous system drug discovery programs targeting muscle spasms associated with rheumatoid arthritis and other musculoskeletal disorders. Neuroscience Research
Essential tool for investigating GABAergic pathways and central muscle relaxation mechanisms. Used in electrophysiological studies, receptor binding assays, and in vitro models to understand the molecular basis of muscle tone regulation and spasticity treatment.

Analytical Reference Standard
High-purity Afloqualone serves as a certified reference material for analytical laboratories conducting forensic analysis, drug testing, and quality control in pharmaceutical manufacturing. Its well-defined chemical properties ensure accurate calibration and method validation.

Custom Synthesis & Medicinal Chemistry
Key building block for synthesizing novel quinazolinone derivatives with modified pharmacological profiles. Widely used by contract research organizations (CROs) and pharmaceutical companies for lead optimization and development of patentable chemical entities.

Veterinary Medicine Research
Emerging applications in veterinary pharmacology for developing species-specific muscle relaxants and studying comparative neuropharmacology across different animal models.

Product Features

Premium Pharmaceutical Grade: ≥98% HPLC purity with strict control of residual solvents and heavy metals
Excellent Stability: Stable crystalline form with minimal degradation under proper storage conditions Superior Solubility Profile: Soluble in DMSO, ethanol, and other organic solvents commonly used in research applications Batch-to-Batch Consistency: Rigorous quality control with comprehensive analytical documentation including NMR, MS, and HPLC chromatograms
Research-Grade Certification: Supplied with Certificate of Analysis and detailed analytical data for each batch
Scalable Production: Available from milligram to multi-kilogram quantities with consistent quality parameters
Packaging & Storage

Packaging Options: 10 mg, 50 mg, 100 mg, 1 g, 5 g, 10 g, or customized bulk packaging in amber glass vials under inert atmosphere
Storage Conditions: Store at -20°C in airtight containers, protected from light and moisture Shelf Life: 24 months when stored under recommended conditions
Transport: Temperature-controlled shipping with dry ice for international orders; standard cold chain logistics for domestic shipments

Why Choose Us

Direct Manufacturer: Vertically integrated production facilities ensuring consistent quality and competitive pricing
Advanced Analytical Capabilities: State-of-the-art QC laboratory with HPLC, LC-MS, NMR, and FTIR for comprehensive product characterization
GMP Compliance: Manufacturing processes adhering to Good Manufacturing Practices with full documentation and traceability systems
Technical Expertise: Dedicated team of medicinal chemists and pharmacology specialists providing application support and custom synthesis services
Global Regulatory Compliance: Products manufactured and tested according to ICH guidelines with comprehensive regulatory documentation support
Flexible Order Options: Low minimum order quantities for research needs with volume discounts and customized specifications for commercial applications
Note: This product is intended for research use only and is not approved for diagnostic or therapeutic applications in humans or animals. All specifications subject to change without notice. Contact us for customized purity requirements, special packaging requests, or bulk pricing inquiries. Certificate of Analysis and Safety Data Sheet available upon request.

ECHEMI Editorial Reference

Afloqualone is a agonist of GABA receptor .Target: GABA Receptorin vitro: Afloqualone is a quinazolinone family GABAergic drug.Afloqualone is an analogue of methaqualone. It has sedative and muscle-relaxant effects, resulting from its agonist activity at the β subtype of the GABAa receptor.in vivo: Afloqualone slightly increased the response during the alarm period in one out of 3 rats at 5, 10, and 20 mg/kg p.o., respectively.

Basic Info

Product Name:

Afloqualone

Other Name:

4(3H)-Quinazolinone,6-amino-2-(fluoromethyl)-3-(2-methylphenyl)-;6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)-4(3H)-quinazolinone;H 495;Afloqualone;HQ 495;Arofuto;Aroft;6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4(3H)-one;154088-26-3

CAS No.:

56287-74-2

Molecular Formula:

C16H14FN3O

InChIKeys:

InChIKey=VDOSWXIDETXFET-UHFFFAOYSA-N

Molecular Weight:

283.3

Exact Mass:

283.30

UNII:

CO4U2C8ORZ

DSSTox ID:

DTXSID5022562

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

58.7

XLogP3:

1.28

Density:

1.3±0.1 g/cm3

Melting Point:

195-196 °C

Boiling Point:

492.5±55.0 °C at 760 mmHg

Flash Point:

251.7±31.5 °C

Refractive Index:

1.642

Toxicity:

Oral-rat LD50：249 mg/kg; Oral-Mouse LD50: 397 mg/kg

Flammability characteristics:

Flammable; burning releases toxic nitrogen oxide and fluoride fumes

See More Afloqualone Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Afloqualone Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst

Location:
https://www.dideu.com/en/

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7

Total Annual Revenue:
Above $100 million

Total Employees:
Above 1000

Year of Establishment:
2016

Certifications:
ISO Certificate,REACH

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