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4-Benzyloxyindole CAS:20289-26-3

Name: 4-Benzyloxyindole CAS:20289-26-3
Brand: Orient
SKU: pr2512231374
Price: 4 USD
Availability: InStock

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CAS No.:

20289-26-3

Grade:

Industrail Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

1KG, 5KG, 25KG

Price valid (until):

2026-01-23

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Name:	4-Benzyloxyindole
Synonyms:	4-(phenylmethoxy)-1h-indole;4-BENZYLOXY-1H-INDOLE;4-BENZYLOXYINDOLE;4-BENZYLOXYLINDOLE;NSC 92539;4-BENZYLOXYINDOLE 98%;{[(1H-Indol-4-yl)oxy]methyl}benzene;4-(Benzyloxy)-1H-indole 98%
CAS:	20289-26-3
MF:	C15H13NO
MW:	223.27
EINECS:	243-690-0
Product Categories:	Simple Indoles;Indole;Chiral Compound;Aromatics;Indole Derivatives;Pyrroles & Indoles;blocks;IndolesOxindoles;Indoles and derivatives;Aromatics Compounds;Indoles;Building Blocks;Heterocyclic Building Blocks;Heterocycle-Indole series;Pyrroles & Indoles;Indoline & Oxindole;Indole Series;bc0001
Mol File:	20289-26-3.mol

4-Benzyloxyindole Chemical Properties

Melting point	57-61 °C (lit.)
Boiling point	364.56°C (rough estimate)
density	1.0707 (rough estimate)
refractive index	1.5500 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	17.17±0.30(Predicted)
color	Beige to Brown
BRN	183150
InChI	InChI=1S/C15H13NO/c1-2-5-12(6-3-1)11-17-15-8-4-7-14-13(15)9-10-16-14/h1-10,16H,11H2
InChIKey	LJFVSIDBFJPKLD-UHFFFAOYSA-N
SMILES	N1C2=C(C(OCC3=CC=CC=C3)=CC=C2)C=C1
CAS DataBase Reference	20289-26-3(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	3
HazardClass	IRRITANT
HS Code	29339990

MSDS Information

4-Benzyloxyindole Usage And Synthesis

Chemical Properties	Off-White Crystalline Solid with Few Darker (Brown) Particles
Uses	Indole derivative as substrate-binding; N297Q and I300V mutants of cytochrome P 450 2A6 display expansion of substrate specificity of cytochrome P 450 2A6 to oxidize substituted indoles
Uses	4-Benzyloxyindole was used in the synthesis of 4-alkyloxy-aminoalkyl indole derivatives.
Reactions	4-Benzyloxyindole was used in the synthesis of 4-alkyloxy-aminoalkyl indole derivatives. Reactant for regioselective synthesis of oxopyrrolidine analogs via iodine-catalyzed Markovnikov addition Reactant for preparation of indoles by Bartoli reductive cyclization as useful intermediates in medicinal chemistry research Reactant for synthesis of carbon-11-labeled 4-aryl-4H-chromenes as new PET agents for imaging of apoptosis in cancer Reactant for preparation of HCV inhibitors. Reactant for preparation of indol-3-yl tetramethylcyclopropyl ketones as CB2 cannabinoid receptor ligands Reactant for preparation of 4-aryl-4H-chromenes as apoptosis inducers
Synthesis Reference(s)	Organic Syntheses, Coll. Vol. 7, p. 34, 1990 The Journal of Organic Chemistry, 51, p. 4294, 1986 DOI: 10.1021/jo00372a037 Tetrahedron Letters, 24, p. 4561, 1983 DOI: 10.1016/S0040-4039(00)85955-9
Synthesis	To a stirred solution of 162.2 g (0.50 mol) of (E)-6-benzyloxy-2-nitro-β-pyrrolidinostyrene in 1 L of THF and 1 L of methanol at 30°C under nitrogen is added 10 mL of Raney nickel followed by 44 mL (0.75 mol) of 85% hydrazine hydrate. Vigorous gas evolution is observed. The red color turns dark brown within 10 minutes, and the reaction temperature rises to 46°C. An additional 44 mL of 85% hydrazine hydrate is added after 30 min and again 1 hr later. The temperature is maintained between 45 and 50°C with a water bath during the reaction and for 2 hr after the last addition. The mixture is cooled to room temperature, and the catalyst is removed by filtration through a bed of Celite. The catalyst is washed several times with methylene chloride. The filtrate is evaporated, and the residue is dried by evaporating with 500 mL of toluene. The reddish residue (118.5 g), dissolved in ca. 1 L of toluene-cyclohexane (1 : 1), is applied to a column of 500 g of silica gel (70–230-mesh, Merck) prepared in the same solvent. Elution with 6.0 L of toluene–cyclohexane (1 : 1) followed by 3 L of toluene–cyclohexane (1 : 2) affords 108.3 g of white solid, which is crystallized from 150 mL of toluene and 480 mL of cyclohexane. 107.3 g (96% yield) of 4-benzyloxyindole is obtained in three crops as white prisms, mp 60–62°C.

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

4-Benzyloxyindole

Other Name:

1H-Indole,4-(phenylmethoxy)-;Indole,4-(benzyloxy)-;4-(Phenylmethoxy)-1H-indole;4-Benzyloxyindole;4-Benzyloxy-1H-indole;NSC 92539;CC-1-33

CAS No.:

20289-26-3

Molecular Formula:

C15H13NO

InChIKeys:

InChIKey=LJFVSIDBFJPKLD-UHFFFAOYSA-N

Molecular Weight:

223.27

Exact Mass:

223.27

BRN:

183150

EC Number:

243-690-0

NSC Number:

92539

DSSTox ID:

DTXSID60174155

HScode:

29339990

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

XLogP3:

3.5

Appearance:

white to off-white powder

Density:

1.2±0.1 g/cm3

Melting Point:

72-74 °C

Boiling Point:

411.6°C at 760 mmHg

Flash Point:

148.9±12.0 °C

Refractive Index:

1.670

Vapor Pressure:

1.31E-06mmHg at 25°C

See More 4-Benzyloxyindole Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 4-Benzyloxyindole Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
Netherlands	4 benzyloxyindole	100 G	Jul 7, 2025

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