99% Diacerein EP STandard CAS 13739-02-1 White Raw Power

Diacerein More Info Diacerein is a synthetic anthraquinone derivative, specifically a diacetylated derivative of rhein, with the CAS Registry Number 13739-02-1. Its molecular structure consists of a hydroxylated anthraquinone core, where the hydroxyl groups are acetylated. This acetylation is a prodrug design; upon ingestion, diacerein is rapidly deacetylated in the body to yield its active metabolite, rhein. Rhein is a naturally occurring compound found in medicinal plants like rhubarb and senna. Diacerein itself is typically a yellow crystalline powder.

The primary mechanism of action for diacerein is distinct from that of traditional NSAIDs and is attributed to its active metabolite, rhein. Rhein exerts potent anti-inflammatory effects primarily by inhibiting the pro-inflammatory cytokine interleukin-1 beta. It does this by interfering with the activation pathways of the IL-1β converting enzyme and by modulating various intracellular signaling cascades involved in inflammation and cartilage degradation. This targeted cytokine inhibition leads to a reduction in the production of other destructive mediators, proteolytic enzymes, and prostaglandins within osteoarthritic joints.

The main clinical application of diacerein is in the symptomatic treatment of osteoarthritis, particularly of the knee and hip. It is classified as a symptomatic slow-acting drug for osteoarthritis, meaning it reduces pain and improves function with a delayed onset of action but may also have potential structure-modifying effects by slowing cartilage breakdown. Its use is especially considered for patients who require long-term management and for whom NSAIDs may be contraindicated due to gastrointestinal or renal risks. It is not intended for the rapid relief of acute pain.

Diacerein is administered orally in capsule form, with a typical dosage of 50 mg taken twice daily. Its pharmacokinetics are defined by its rapid and complete conversion to rhein after absorption. The active rhein metabolite is then extensively metabolized in the liver via glucuronidation and excreted primarily in the urine. The therapeutic effects on pain and stiffness may take several weeks to become fully apparent, consistent with its SYSADOA classification, and treatment is usually long-term.

The safety profile of diacerein is characterized by a notably different side effect pattern compared to NSAIDs. The most common adverse effect is a dose-dependent change in bowel habits, particularly mild to moderate diarrhea and soft stools, which occurs in a significant proportion of patients and is related to the anthraquinone structure. This often diminishes with continued use. A distinctive side effect is the reversible orange-yellow discoloration of urine. Unlike NSAIDs, it does not pose a significant risk of peptic ulcers, renal impairment, or cardiovascular events, making it a valuable option for certain patient populations, though it is contraindicated in pregnancy and severe hepatic or renal impairment.

Package Image

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.