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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide CAS:1892-57-5

Name: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide CAS:1892-57-5
Brand: Orient
SKU: pr2512292346
Price: 4 USD
Availability: InStock

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CAS No.:

1892-57-5

Grade:

Industrail Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

1KG, 5KG, 25KG

Price valid (until):

2026-01-29

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Name:	1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
Synonyms:	1-ETHYL-3-(3-DIMETHYLAMINOPROPYL) CARBODIIMIDE;1-(3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE;WATER-SOLUBLE CARBODIIMIDE;WSCD;WSCI;N-ETHYL-N'-(3-DIMETHYLAMINOPROPYL)CARBODIIMIDE;[3-(Dimethylamino)propyl]ethylcarbodiimide;ethyldimethylaminopropylcarbodiimide
CAS:	1892-57-5
MF:	C8H17N3
MW:	155.24
EINECS:	217-579-2
Product Categories:	straight chain compounds
Mol File:	1892-57-5.mol

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Chemical Properties

Boiling point	66-68°C/1mm
density	0.877 g/mL at 20 °C (lit.)
refractive index	n20/D 1.461
Fp	66-68°C/1mm
storage temp.	-20°C
solubility	Chloroform
pka	9.52±0.28(Predicted)
form	Liquid
color	Colorless to slightly yellow
Specific Gravity	0.885
Water Solubility	Soluble in water.
Sensitive	Air Sensitive
BRN	507429
InChIKey	LMDZBCPBFSXMTL-UHFFFAOYSA-N
CAS DataBase Reference	1892-57-5(CAS DataBase Reference)
NIST Chemistry Reference	1,3-Propanediamine, n'-(ethylcarbonimidoyl)-n,n-dimethyl-(1892-57-5)
EPA Substance Registry System	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl- (1892-57-5)

Safety Information

Hazard Codes	C
Risk Statements	34
Safety Statements	26-36/37/39-45
RIDADR	UN 2735 8/PG 3
WGK Germany	3
F	1-3-10
TSCA	Yes
HazardClass	8
PackingGroup	III
HS Code	29252900

MSDS Information

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Usage And Synthesis

Description	1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is a water-soluble carbodiimide available as hydrochloride salt. This compound is a carboxyl- and amine-reactive crosslinker that is water soluble and can activate carboxyl residues for their reaction with primary amines to form O-acylisourea as a reaction intermediate, which reacts with amide bonds to release isourea as a by-product. It can crosslink the carboxy-group of glutamate and aspartate to the side-chain primary amine of lysine and the amino group at the N-terminus. The crosslinker readily reacts at a pH range of 4.5–7.2 and only crosslinks the residues within their van der Waals distance. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is also widely used in fabricating different nanosystems implemented in drug/protein delivery systems. It is mainly used for surface crosslinking/immobilization of drugs to increase stability against environmental changes, such as pH or temperature[1-2].
Chemical Properties	Clear light yellow liquid
Uses	1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is used as a carboxyl activating agent and activate phosphate groups in phospho mono and di esters. It is used in peptide synthesis, 3'-amino-3'-deoxyadenosine-5'-di- and triphosphates and in the preparation of antibodies like immunoconjugates. It plays a vital role for immobilization of large biomolecules in association with N-hydroxysuccinimide. It is also used in the acylation of phosphoranes.
General Description	N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide is commonly used in combination with N-hydroxysuccinimide (NHS) in carbodiimide coupling reaction to activate carboxyl group for coupling with amines to form amides.
reaction suitability	reaction type: Coupling Reactions
Synthesis	The production method of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide is to react with N, N'-dimethylpropanediamine and carbon disulfide as raw materials to prepare N, N'- Dimethylpropylthiourea. Then it is oxidized with ethyl chloroformate to obtain N, N'-dimethylpropyl isothiocyanate, which is then reacted with ethylamine and oxidized with sodium hypochlorite to obtain the product 1-(3-dimethylaminopropyl)-3- Ethylcarbodiimide.

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

Firefighting measures

Extinguishing media

Use dry chemical, carbon dioxide or alcohol-resistant foam.

Specific Hazards Arising from the Chemical

no data available

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide

Other Name:

1,3-Propanediamine,N3-(ethylcarbonimidoyl)-N1,N1-dimethyl-;Carbodiimide,[3-(dimethylamino)propyl]ethyl-;1,3-Propanediamine,N′-(ethylcarbonimidoyl)-N,N-dimethyl-;N3-(Ethylcarbonimidoyl)-N1,N1-dimethyl-1,3-propanediamine;1-Ethyl-3-[3-(dimethylamino)propyl]carbodiimide;1-Ethyl-3-(dimethylaminopropyl)carbodiimide;N-Ethyl-N′-(3-dimethylaminopropyl)carbodiimide;3-(3-Dimethylaminopropyl)-1-ethylcarbodiimide;Dec;1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide;1-[3-(Dimethylamino)propyl]-3-ethylcarbodiimide;EDAC;N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide;1-Ethyl-3-(N,N-dimethylamino)propylcarbodiimide;EDC;3-Ethyl-1-(3-dimethylaminopropyl)carbodiimide;([[3-(Dimethylamino)propyl]imino]methylidene)(ethyl)amine;(3-Dimethylamino-propyl)-ethyl-carbodiimide;205250-00-6

CAS No.:

1892-57-5

Molecular Formula:

C8H17N3

InChIKeys:

InChIKey=LMDZBCPBFSXMTL-UHFFFAOYSA-N

Molecular Weight:

155.24

Exact Mass:

155.24

BRN:

507429

EC Number:

217-579-2

UNII:

RJ5OZG6I4A

HScode:

2925290090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

XLogP3:

1.9

Appearance:

Colorless to slightly yellow Liquid

Density:

0.9±0.1 g/cm3

Melting Point:

115ºC

Boiling Point:

53-54 °C @ Press: 0.6 Torr

Flash Point:

66-68°C/1mm

Refractive Index:

1.459

Water Solubility:

soluble in water.

Storage Conditions:

−20°C

Vapor Pressure:

0.373mmHg at 25°C

See More 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide Properties 

Hazard Identification

Classification of the substance or mixture

Skin corrosion, Sub-category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H314 Causes severe skin burns and eye damage
Prevention	P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide	2 MT	Feb 25, 2025
Nigeria	EDC 99%	200 L	Jul 17, 2023

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