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Medetomidine hydrochloride 86347-15-1

Name: Medetomidine hydrochloride 86347-15-1
Brand: Orient
SKU: pr2512251016
Price: 4 USD
Availability: InStock

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CAS No.:

86347-15-1

Grade:

Industrail Grade

Content:

99%

Port:

shanghai

Brand:

Orient

Packaging:

1KG, 5KG, 25KG

Price valid (until):

2026-01-25

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Name:	Medetomidine hydrochloride
Synonyms:	MEDETOMIDINE HYDROCHLORIDE;(r)-4-[1-(2,3-dimethylphenyl)ethyl]-1h-imidazole hydrochloride;1H-Imidazole, 5-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1);5-[1-(2,3-diMethylphenyl)ethyl]-1H-IMidazole hydrochloride;edetomidine;Medetomidine hydrochloride (R)-4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride;5-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole monohydrochloride;Metetomidine HCl
CAS:	86347-15-1
MF:	C13H17ClN2
MW:	236.74
EINECS:	645-306-0
Product Categories:	Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors
Mol File:	86347-15-1.mol

Medetomidine hydrochloride Chemical Properties

Melting point	164-166°C
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	Acetonitrile (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
color	White to Off-White
biological source	synthetic
InChI	InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H
InChIKey	VPNGEIHDPSLNMU-UHFFFAOYSA-N
SMILES	C(C1N=CNC=1)(C1C=CC=C(C)C=1C)C.Cl

Safety Information

MSDS Information

Medetomidine hydrochloride Usage And Synthesis

Description	Medetomidine hydrochloride is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). It is an imidazole compound. Medetomidine hydrochloride shows greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). In addition, it influences the adrenergic system by mimicking the action of adrenergic neurotransmitters.
Chemical Properties	White Solid
Uses	Medetomidine is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor
Uses	An α2-Adrenergic agonist. Sedative; analgesic.
Definition	ChEBI: Medetomidine hydrochloride is a hydrochloride.
Indications	Medetomidine hydrochloride is an FDA-approved alpha2-adrenoceptor (α2-AR) agonist with analgesic, sedative and anxiolytic properties for use as a veterinary sedative. It has been approved for use in animals such as cats, sheep, and dogs (12 weeks of age and older.) In 1999, the FDA approved Medetomidine for human use in the sedation of intubated and mechanically ventilated intensive care unit (ICU) patients, including use as a pain reliever and for use in non-intubated patients prior to and during surgery and other procedures. In addition to its pharmaceutical uses, it is used as an antifouling agent in marine coatings.^[1]
Biological Activity	medetomidine is a selective α2-adrenoceptor agonist, with ki of 1.08 nm, exhibts 1620-fold selectivity over α1-adrenoceptor.
Pharmacokinetics	After intramuscular injection, medetomidine is rapidly and almost completely absorbed at the site of injection and its pharmacokinetics are very similar to that observed after intravenous injection. Maximum plasma concentrations are reached within 15 to 20 minutes. Estimated plasma half-life is 1.2 hours for dogs and 1.5 hours for cats. Medetomidine is mainly oxidised in the liver, while a small amount is methylated in the kidney. Metabolites are primarily excreted in urine.
Side effects	Medetomidine hydrochloride is an alpha-2 adrenoreceptor agonist. Symptoms after absorption may involve clinical effects, including dose dependent sedation, respiratory depression, bradycardia, hypotension, a dry mouth, and hyperglycaemia. Ventricular arrhythmias have also been reported. Respiratory and haemodynamic symptoms should be treated symptomatically.
Synthesis	Medetomidine hydrochloride is synthesized using 2,3-Dimethylbromobenzene as the starting material through a series of Grignard reactions. This process yields tertiary alcohol 7, which is subsequently subjected to dehydration and hydrogenation. The overall yield achieved was 17 percent.^[1] The reaction scheme is illustrated as follows: Additional synthetic processes encompass:

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

1H-Imidazole, 5-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1)

Other Name:

1H-Imidazole,5-[1-(2,3-dimethylphenyl)ethyl]-,hydrochloride (1:1);1H-Imidazole,4-[1-(2,3-dimethylphenyl)ethyl]-,monohydrochloride;Medetomidine hydrochloride;Domitor;MPV 785;Zalopine;119264-93-6

CAS No.:

86347-15-1

Molecular Formula:

C13H16N2.ClH

InChIKeys:

InChIKey=VPNGEIHDPSLNMU-UHFFFAOYSA-N

Molecular Weight:

236.74

Exact Mass:

236.108032

EC Number:

2017-001-1

DSSTox ID:

DTXSID3045691

HScode:

2942000000

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

28.7

XLogP3:

3.98030

Appearance:

White or off white crystalline powder

Melting Point:

164-166°C

Boiling Point:

381.9°C at 760 mmHg

Flash Point:

191.3ºC

Storage Conditions:

Refrigerator

See More 1H-Imidazole, 5-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1) Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 2, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H300 Fatal if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 1H-Imidazole, 5-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1) Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

19 Inquiries

Country	Product	Purchase Quantity	Date Posted
Canada	86347-15-1	5 KG	Dec 30, 2025
United States	Medetomidine hydrochloride \| CAS 86347-15-1	1 KG	Sep 22, 2023
Canada	Factory Supply High Purity Medetomidine Hydrochloride CAS 86347-15-1 Medetomidine	25 KG	Oct 3, 2023
United States	Medetomidine Hydrochloride	10 G	Feb 25, 2026
United States	Medetomidine hcl	10 G	May 17, 2026
Canada	Medetomidine Hydrochloride	1 KG	May 4, 2026
United States	Medetomidine	1 G	Apr 13, 2026
Canada	Medetomidine	1 KG	Dec 25, 2025
United States	Medetomidine Hydrochloride	1 G	Dec 24, 2025
India	Medetomidine Hydrochloride	1 KG	Sep 8, 2025
India	Medetomidine hydrochloride	100 G	Apr 23, 2025
United States	Medetomidine hcl	50 G	May 27, 2026
United States	medetomidine	5 MG	May 26, 2026
Canada	Medetomodine HCl	250 G	Apr 19, 2026
Canada	Medetomidne hydrochloride	28 G	Jan 23, 2026
United States	Medetomidine hydrochloride	100 G	Dec 31, 2025
United States	Medetomidine hydrochloride	1 KG	May 18, 2025
India	Medetomidine hcl	10 G	Apr 29, 2025
United States	Medetomidine	100 G	Dec 10, 2025

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