Aminopterin RC08190
54-62-6
Pharmaceutical Grade
99%
Royalchem
25kg/drum
Yes
2030-01-01
Pharmaceutical intermediates
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceAminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia[1][2].
SolidBasic Info-
Product Name:
Aminopterin
Other Name:L-Glutamic acid,N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-;Glutamic acid,N-[p-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-,L-;N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid;NSC 739;Aminopterin;4-Aminopteroylglutamic acid;Aminopterine;4-Aminofolic acid;APGA;Pteramina;(2S)-2-[[4-[(2,4-Diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid;120382-78-7;64801-55-4
CAS No.:54-62-6
Molecular Formula:C19H20N8O5
InChIKeys:InChIKey=TVZGACDUOSZQKY-LBPRGKRZSA-N
Molecular Weight:440.41
Exact Mass:440.41
EC Number:200-209-9
NSC Number:757427|739
DSSTox ID:DTXSID50873145
HScode:2933990090
Categories:
Characteristics-
PSA:
219.33000
XLogP3:-1.21
Appearance:yellow powder
Density:1.6±0.1 g/cm3
Melting Point:228-235 °C (dec.)
Flash Point:87℃
Refractive Index:1.762
Water Solubility:2 M NaOH: 50 mg/mL
Storage Conditions:2-8°C
Vapor Pressure:2.3X10-19 mg Hg at 25 °C /Estimated/
Toxicity:Oral-ratLDL0: 2.5 mg/kg; Oral-Mouse LD50: 3 mg/kg
Flammability characteristics:Flammable; burning produces toxic nitrogen oxide fumes
Specific rotation:18 º (c=1% in 0.1N NaOH)
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 2, Oral
Reproductive toxicity, Category 1B
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H300 Fatal if swallowed
H360 May damage fertility or the unborn child
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceutical intermediates
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Location:
Room 336, Building 7, No. 177 Xingqiao North Road, Xingqiao Street, Linping District, Hangzhou
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Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
14 days
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Total Annual Revenue:
Less than $1 million
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Total Employees:
Less than 5
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Year of Establishment:
2025
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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