High Purity Tauroursodeoxycholic Acid CAS:14605-22-2 | Pharma Grade Bile Acid API Raw Material

Tauroursodeoxycholic acid More Info

Tauroursodeoxycholic acid is a hydrophilic bile acid, formed by the conjugation of taurine to ursodeoxycholic acid, with the CAS Registry Number 14605-22-2. Its molecular structure features a steroid nucleus with hydroxyl groups in specific positions and a polar taurine side chain, which significantly increases its water solubility compared to unconjugated bile acids. This conjugation mimics a natural human bile acid and is a key determinant of its biochemical stability, cellular uptake, and pharmacological activity. It typically appears as a white to off-white crystalline powder.

The compound's mechanism of action is multifaceted and cytoprotective. As a hydrophilic bile acid, it functions primarily by displacing more toxic, hydrophobic endogenous bile acids from the bile acid pool, reducing their damaging effects on cell membranes. It also acts as a chemical chaperone, reducing endoplasmic reticulum stress and inhibiting apoptosis by stabilizing mitochondrial membranes and preventing cytochrome c release. Furthermore, it exhibits anti-inflammatory and anti-oxidative properties, modulating various signaling pathways to promote cell survival.

TUDCA has significant clinical and research applications. Clinically, it is approved in some countries as a pharmaceutical agent for the treatment of cholestatic liver diseases, such as primary biliary cholangitis. Its neuroprotective properties have driven extensive research into its potential for treating neurodegenerative disorders, including amyotrophic lateral sclerosis, Alzheimer's disease, and retinal degeneration. Additionally, it is widely used as a dietary supplement to support liver and metabolic health, and is a common reagent in cell culture to mitigate ER stress in experimental models.

This bile acid is administered orally in capsule form for therapeutic and supplemental use. It is well-absorbed in the ileum via active transport, undergoes enterohepatic circulation, and is eventually excreted in feces. Its pharmacokinetics are favorable, with good bioavailability. In research, it is also applied directly to cell cultures. The typical therapeutic dosage for liver conditions is in the range of several hundred milligrams per day, while supplemental and research doses vary widely based on the intended outcome.

The safety profile of TUDCA is excellent, owing to its status as a natural, endogenous bile acid conjugate. It is generally very well-tolerated, even at high doses. The most commonly reported side effects are mild and gastrointestinal, such as diarrhea or soft stools, which are typical of bile acid therapies. No significant drug interactions or serious long-term toxicities have been established. Its strong safety record, combined with potent cytoprotective actions, has made it a compound of high interest for both clinical development and translational research across a spectrum of diseases involving cellular stress.

Package Image

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.