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hot sale high quality raw materia Rapamycin Sirolimus CAS 53123-88-9

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CAS No.:

53123-88-9

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shenzhen

Brand:

Packaging:

25kg drum

Sample Available:

Yes

Price valid (until):

2026-04-03

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HNB Biotech

Company Type:

Manufactory

Location:

China

Payment Terms:

L/C,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

7 days

Qualification:

Main Products:

Ivermectin,Active pharmaceutical ingredients,Cosmetics material,Chemical intermediate,Nootropic,Food additive

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Product Description
Seller Information
Inquiry History

Description

Product Detail

whasapp：+8615202961574
Email:gary@xahnb.com

Items	Specifications
Product Name	rapamycin sirolimus
MF	C51H79NO13
CAS	110-27-0

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Product Name: Rapamycin

Synonyms: Sirolimus, Rapa

CAS: 53123-88-9

MF: C51H79NO13

MW: 914.19

EINECS: 610-965-5

Appearance: Almost white powder

Rapamycin (Rapa, or Sirolimus) is a new form of macrolide immunosuppressive agent. It is a white solid crystal.

Its melting point is 183-185℃ and it is lipophilic. It is soluble in , acetone, chloroform, and other

organic solvents, very slightly soluble in water, and almost insoluble in ether. It was first discovered in 1975 on the

Chilean Easter Island as a secondary metabolite secreted by soil Streptomyces, and its chemical structure is that of

a three-polyene macrolide compound.

What is Rapamycin?

Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor.

Rapamycin exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP (RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases,which have PI 4-kinase and autophosphorylating activities.

The rapamycin/FKBP complex does not inhibit the FRAP PI 4-kinase activity,but does inhibit FRAP autophosphorylation.

Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells.

Rapamycin also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is
potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Angiogenesis inhibition is also exhibited,possibly through the inhibition of the Akt pathway.

Rapamycin is an inhibitor of mTOR.

Items	Standard		Test Results

Identification	A.H-NMR:Comply with the structure		Complies
	B.LC-MS:Comply with the structure		Complies
	C.The IR spectrum of sample should be identical with that of reference standard.		Complies
	D.HPLC-ESI-MS The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.		Complies
Loss on drying %	≤2.0		0.19
Heavy metals ppm	≤10		<10
Moisture %	≤1.0		0.1
Sulphated ash %	≤0.5 determined on 1.0 g.		0.009
Residue on ignition %	≤0.1		0.03
Related Substances %	Unspecified impurities: for each impurity	≤0.10	<0.10
Related Substances %	Total Impurity	≤0.5	0.18
Purity %	≥99.0		99.7
Assay %	99.0 ~101.0 (anhydrous substance).		99.8
Storage	Preserve in well-closed, light-resistant and airtight containers.		Complies

As an mTOR inhibitor, sirolimus has a broad spectrum of activity that has demonstrated the ability to inhibit

inflammation, proliferation, angiogenesis, fibrosis, and hyperpermeability. Sirolimus currently has multiple uses

in the prevention of rejection in organ transplantation and, recently, in the treatment of advanced renal cell carcinoma.

Sirolimus-eluting cardiac stents have been shown to limit the rate of overgrowth of tissue and thus prevent coronary

restenosis. Early studies suggest that it may be an effective agent for controlling severe uveitis and that it may also

have a role in treating agerelated macular degeneration.

Function

Rapamycin is a triene macrolide antibiotic,which demonstrates anti-fungal,anti-inflammatory,anti-tumor and immunosuppressive
properties.

Rapamycin has been shown to block T-cell activation and proliferation,as well as,the activation of p70 S6 kinase and exhibits strong
binding to FK506 binding proteins.

Rapamycin also inhibits the activity of the protein,mTOR(mammalian target of rapamycin) which functions in a signaling pathway to
promote tumor growth.

Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction
of mTOR with target proteins in this signaling pathway.

Rapamycin (RAPA) is a novel macrolide immunosuppressant is now often used as a transplanted organ to maintain immunity drugs
(especially kidney transplants), to mitigate the immune organ rejection after transplant surgery, but scientists it recently found another
purpose: for the treatment of Alzheimer's disease (senile dementia).

Target of rapamycin (mTOR) as an intracellular kinases pathway abnormalities can induce a variety of diseases. As rapamycin mTOR
inhibitor targeting, to treat with this pathway is closely related to tumors, including renal cell carcinoma, lymphoma, lung cancer,
liver cancer, breast cancer, neuroendocrine carcinoma and gastric cancer

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Q1 Can i get some samples
A1 Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2 How to start orders or make payments
A2 Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T,or Paypal or Escrow(Alibaba).
Q3 How to confirm the Product Quality before placing orders
A3 You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q4 What's your MOQ
A4 Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5 How about delivery leadtime
A5 Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q6 Is there a discount
A6 Different quantity has different discount.
Q7 How do you treat quality complaint
A7 First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q8 How to contact us
A8 You can chat with us by Trademanager,MSN&Skype Online.
You can choose your interested products and send inquiry to us.
You can dial our telephone directly or send Email to us., you will get our reply.

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ECHEMI Editorial Reference

Rapamycin (Sirolimus) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM.

Certificates

Basic Info

Product Name:

Rapamycin

Other Name:

Rapamycin;23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine,rapamycin deriv.;Antibiotic AY 22989;[3S-[3R*[S*(1R*,3S*,4S*)],6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*]]-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone;23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-,[3S-[3R*[S*(1R*,3S*,4S*)],6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*]]-;(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone;AY 22989;(-)-Rapamycin;Sirolimus;SIIA 9268A;Rapamune;Rapammune;RPM;NSC 226080;RAPA;Wy 090217;Cypher;Nab rapamycin;Supralimus;14S-Rapamycin;Cypher Bx Velocity;PNP-sirolimus;DE 109;MS-RO01;MS-RO02;MS-RO03;Perceiva;Rapamysin;SVP-R;1179372-35-0;1189166-54-8;1233221-34-5;1353039-01-6

CAS No.:

53123-88-9

Molecular Formula:

C51H79NO13

InChIKeys:

InChIKey=QFJCIRLUMZQUOT-HPLJOQBZSA-N

Molecular Weight:

914.18

Exact Mass:

914.17

EC Number:

262-640-9

HScode:

2942000000

Categories:

Drugs Influencing Immune Function

Characteristics

PSA:

195

XLogP3:

Appearance:

yellow solid

Density:

1.2±0.1 g/cm3

Melting Point:

183-185 °C

Boiling Point:

973°C at 760 mmHg

Flash Point:

87 °C

Refractive Index:

1.551

Water Solubility:

soluble in DMSO at 50mg/ml or methanol at 25mg/ml. soluble in alcohol, dimethyl sulfoxide and dimethyl formamide. Insoluble in water.ethanol: soluble 2 MM

Storage Conditions:

-20°C

Vapor Pressure:

0.56 hPa ( 20 °C)

Toxicity:

LD50 in mice (mg/kg): 600 i.p.; >2,500 orally (Vézina)

Specific rotation:

D25 -58.2° (methanol)

See More Rapamycin Properties 

Hazard Identification

Classification of the substance or mixture

Carcinogenicity, Category 2

Reproductive toxicity, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H351 Suspected of causing cancer H361 Suspected of damaging fertility or the unborn child H372 Causes damage to organs through prolonged or repeated exposure
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Rapamycin Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ivermectin,Active pharmaceutical ingredients,Cosmetics material,Chemical intermediate,Nootropic,Food additive

Location:
6 floor Baoyilongji Building B Weiyang Area, Fengcheng 8 Road, Xi'an city, Shaanxi, 710000, China

Payment Terms:
L/C,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
51-100

Year of Establishment:
2017

Company Certificates
- ISO
- ISO
Xi'an Harmonious Natural Bio-Technology Co., Ltd. was founded in 2010, and located in Xian

International Logistics Industrial Zone, Xi'an City, Shaanxi Province, China. Now it is the

leading researcher and one of the biggest manufacturer in high technology API area.

There are 8 experts in our research team. We insist in innovation and produce high quality

products. And GMP standard workshop and complete stainless extraction equipment.

We have 2 sales departments over 20 people and sell our products all over the world.

We also have strong professional research and development team, talented personnel and

completely equipped laboratory for the quality controlling. Various Detection Device is

equipped in HNB company, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto

titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.

HNB mainly engaged in export of products including, without limitation, pharmaceutical raw

materials both for vet and human, also Vitamins, Amino Acids, minerals, peptides, plant

extract, feed and food additives.

Our company's business is based on Honest, Trustworthy, Constantly to Go Beyond and

Achieve Mutual Win. Sincerely hope to strengthen exchanges and cooperation with friends

from both home and abroad.

Passion to innovate, Power to deliver !

Inquiry History

26 Inquiries

Country	Product	Purchase Quantity	Date Posted
Hungary	Raw Pharmaceutical Grade Material Rapamycin Powder CAS 53123-88-9 with High Purity	100 G	Nov 20, 2023
India	Raw Pharmaceutical Grade Material Rapamycin Powder CAS 53123-88-9 with High Purity	1000 MT	Nov 18, 2023
United States	TNJONE High quality GMP Certificated 99% Purity Sirolimus Rapamycin 53123-88-9 in Stock	1 G	Jan 1, 2025
Paraguay	Rapamycin Sirolimus Powder	1 G	Feb 21, 2024
India	Rapamycin	1 MT	Feb 12, 2026
India	Rapamycin	1.00 KG	Jan 26, 2024
Pakistan	Sirolimus/Rapamycin	10 G	Sep 9, 2026
United States	Rapamycin	50 MG	Apr 17, 2026
United States	rapamycin	100 G	Sep 27, 2025
Philippines	Rapamycin	5 G	Feb 10, 2025
Australia	Rapamycin	99 KG	Nov 3, 2024
United States	Rapamycin	10 MT	May 22, 2024
Canada	Rapamycin	1 KG	Jan 24, 2025
United States	Rapamycin	1 KG	Nov 27, 2024
United States	rapamycin	1 G	Jul 12, 2024
India	Rapamycin	1 KG	Jun 28, 2024
United States	Rapamycin	1 KG	Apr 14, 2025
Canada	Rapamycin	100 MG	Mar 4, 2025
Spain	Rapamycin	1 20' Fcl	Dec 16, 2024
Italy	Rapamycin	1 G	Mar 8, 2024

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hot sale high quality raw materia Rapamycin Sirolimus CAS 53123-88-9

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