Peptide Mots-C CAS 1627580-64-6 Mots-c Acetate Peptide Powder /DSIP /ss-31 Door to door delivery

MOTS-c  More Info

MOTS-c is a mitochondrial-derived peptide consisting of sixteen amino acids, with the specific sequence Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg, and is assigned the CAS Registry Number 1627580-64-6. Unlike most peptides, it is encoded not by the nuclear genome but by a short open reading frame within the mitochondrial twelve S ribosomal RNA gene, making it one of the first identified peptides translated from mitochondrial DNA that exerts hormone-like effects throughout the body. In research settings, it is supplied as a synthetic, lyophilized white powder with high purity.  

The primary mechanism of action involves the activation of AMP-activated protein kinase, a central cellular energy sensor. MOTS-c achieves this by inhibiting the folate cycle and de novo purine synthesis, leading to the accumulation of an endogenous AMP analog which subsequently activates AMPK. Upon activation, AMPK phosphorylates downstream targets that promote mitochondrial biogenesis, enhance glucose uptake and insulin sensitivity, and increase fatty acid oxidation. During metabolic stress, MOTS-c translocates to the nucleus where it binds to the stress-responsive transcription factor Nrf2, activating anti-oxidative stress genes. It also inhibits MAP kinases and suppresses the NF-kappaB inflammatory pathway, contributing to its anti-inflammatory effects.

The research applications of MOTS-c span multiple fields, including metabolism, aging, and various disease states. It is extensively investigated for its potential in treating metabolic disorders such as type two diabetes, obesity, and insulin resistance. Preclinical studies demonstrate its ability to improve glucose homeostasis, reduce diet-induced obesity, and enhance physical performance. Emerging research suggests therapeutic potential in conditions including diabetic cardiomyopathy, where it protects against cardiac dysfunction, fibrosis, and apoptosis. It is also studied in cancer-induced bone pain, where it attenuates pain through AMPK-mediated mitochondrial biogenesis and suppression of microglial activation.

From a biochemical and handling perspective, MOTS-c is soluble in water and can be reconstituted in sterile water for research use. It exhibits excellent stability when stored properly; lyophilized powder remains stable for extended periods at low temperatures. Upon reconstitution, it should be stored under refrigeration for short-term use or frozen for longer storage, with the addition of carrier proteins recommended to prevent loss during long-term storage. Repeated freeze-thaw cycles should be avoided to maintain activity.

The safety and regulatory status of MOTS-c place it firmly within the realm of experimental research compounds. It is not approved by regulatory agencies for human therapeutic use and is strictly designated for laboratory research only. Its biological activity and exercise-mimetic properties have led to its inclusion on the World Anti-Doping Agency list of prohibited substances. Animal studies indicate that chronic administration has minimal effects on liver, renal, lipid, or cardiac function at therapeutic doses. However, comprehensive long-term human safety data are lacking, and its use outside controlled research settings carries inherent and undefined risks. It is exclusively supplied through biochemical reagent suppliers for scientific investigation rather than consumer applications.

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