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API Silibinin

Name: API Silibinin
Brand: Hyper Chem
SKU: pr2603201076
Price: 200 USD
Availability: InStock

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CAS No.:

22888-70-6

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Hyper Chem

Packaging:

20kg/Drum 25kg/Drum

Sample Available:

Yes

Price valid (until):

2026-04-20

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Inquiry History

Description

Name	Silibinin
CAS number	22888-70-6
Description	Silibinin, also known as silybin, contains both A and B diastereomers. Silibinin is the major active constituent of silymarin, standardized extract of the milk thistle seeds, containing mixture of flavonolignans consisting of among others of silibinin, isosilibinin, silicristin and silidianin. Silibinin itself is mixture of two diastereomers Silibinin A and Silybinin B in approximately equimolar ratio. Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins.
Related CAS #	/
Synonym	Flavobin; Silibinin; Silybin; NSC 651520; Silybine; Silymarin I; Silymarine I;
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Silibinin More Info

Silibinin, also known as Silybin, is a flavonoid compound extracted from the seeds of Silybum marianum (milk thistle). It is recognized as the primary active constituent of silymarin, accounting for 70-80% of its composition. Below are the key characteristics and applications of Silibinin:

1. Chemical Profile

Molecular Formula: C25H22O10

Molecular Weight: 482.44 g/mol

CAS Number: 22888-70-6

Physical Form: White to off-white solid (powder or crystalline)

Solubility: Insoluble in water; soluble in organic solvents such as DMSO, ethanol, acetone, and methanol

Purity: Typically >97% (often 98-99%) for research-grade standards

2. Biological Activities & Pharmacological Effects

Silibinin exhibits a broad spectrum of biological activities, making it a valuable compound in both clinical and research settings:

Hepatoprotective: Acts as a potent antioxidant and free radical scavenger, protecting liver cells from toxins, supporting liver regeneration, and treating liver diseases such as hepatitis and cirrhosis.

Anti-Cancer Potential: Demonstrates anti-proliferative and anti-migratory effects in various cancer cell lines. It can induce apoptosis, regulate cell cycle proteins (e.g., upregulating Bax, downregulating Bcl-2), and modulate signaling pathways such as Notch1 and AKT .

Anti-Inflammatory & Antioxidant: Reduces oxidative stress, decreases ROS generation, and exhibits anti-inflammatory properties in both in vitro and in vivo studies.

Other Potential Effects: Includes anti-diabetic, anti-viral, neuroprotective, and cosmetic applications (e.g., protecting skin cells from oxidative damage).

3. Typical Applications

Research Use: Widely used as a standard reference material (USP reference standard) and a research tool for studying liver protection, cancer mechanisms, apoptosis pathways, and oxidative stress models.

Clinical Use: Marketed under brand names such as Legalon and Carsil as a silymarin extract for treating liver disorders. While it has shown promise in clinical trials for liver health, its use as a standalone anti-cancer drug is still under investigation.

4. Storage & Handling

Storage Conditions: Store at 2-8°C, protected from light and moisture. Some suppliers recommend storage at 4°C for enhanced stability.

Stability: Generally stable under recommended storage conditions, with a typical shelf life of 2-3 years for solid forms.

5. Commercial Availability

Product Forms: Available in various forms including solid powder, pre-dissolved DMSO solutions (e.g., 10 mM), and as part of silymarin extracts.

Suppliers: Widely supplied by biochemical and pharmaceutical companies such as MedChemExpress, TargetMol, and others, often accompanied by a Certificate of Analysis (COA).

ECHEMI Editorial Reference

Silibinin, an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.IC50 value:Target: anticancerin vitro: silibinin significantly induced the expression of the non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) in both p53 wild-type and p53-null cancer cell lines, suggesting that silibinin-induced NAG-1 up-regulation is p53-independent manner.Silibinin up-regulat
Silibinin is a flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities. It has a role as an antioxidant, an antineoplastic agent, a hepatoprotective agent and a plant metabolite. It is a flavonolignan, a polyphenol, an aromatic ether, a benzodioxine and a secondary alpha-hydroxy ketone.|Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin and others. Silibinin is presented as a mixture of two diastereomers, silybin A and silybin B, which are found in an approximately equimolar ratio. Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins. Silibinin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells.|The major active component of silymarin flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum; it is used in the treatment of HEPATITIS; LIVER CIRRHOSIS; and CHEMICAL AND DRUG INDUCED LIVER INJURY, and has antineoplastic activity; silybins A and B are diastereomers.

Basic Info

Product Name:

Silybin

Other Name:

4H-1-Benzopyran-4-one,2-[(2R,3R)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-,(2R,3R)-;4-Chromanone,3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxan-6-yl]-;Silybin;4H-1-Benzopyran-4-one,2-[2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-,[2R-[2α,3β,6(2R*,3R*)]]-;1,4-Benzodioxin,4H-1-benzopyran-4-one deriv.;(2R,3R)-2-[(2R,3R)-2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one;Silybine;Silymarin I;7C3MT;Silliver;Silymarine I;Silibinin;Silymarin MZ 80;Silybum substance E6;Silybin A;Silybin b1;Silibinin A;Mepasil;Realsil;142796-20-1;11054-49-2;11076-05-4;11076-06-5;22888-69-3;27359-03-1;28577-40-4;29832-10-8;37574-50-8;50976-99-3;87725-90-4

CAS No.:

22888-70-6

Molecular Formula:

C25H22O10

InChIKeys:

InChIKey=SEBFKMXJBCUCAI-HKTJVKLFSA-N

Molecular Weight:

482.44

Exact Mass:

482.44

EC Number:

245-302-5

UNII:

33X338MNE4

NSC Number:

651520

DSSTox ID:

DTXSID5023580|DTXSID8026018

ATC Code:

A - Alimentary tract and metabolism

HScode:

2932999099

Categories:

Plant Extracts

Characteristics

PSA:

155

XLogP3:

2.4

Appearance:

solid

Density:

1.5±0.1 g/cm3

Melting Point:

158 °C

Boiling Point:

793°C at 760 mmHg

Flash Point:

274.5±26.4 °C

Refractive Index:

1.684

Water Solubility:

54mg/L(24.99 ºC)

Storage Conditions:

−20°C

Vapor Pressure:

1.63E-26mmHg at 25°C

Toxicity:

LD50 intravenous in mouse: 1056mg/kg

Specific rotation:

D20 +11° (c = 0.25 in acetone + alcohol)

Collision Cross Section:

213.6 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

See More Silybin Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Silybin Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Company Certificates
- Certification Report by Bureau Veritas
About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Milk Thistle Extract 80% UV	1.00 MT	Jun 29, 2026

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API Silibinin

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