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100% China origin factory direct supply Silybin 70% Silybin 80% Silybin 90% Silybin 95% used to protect the liver and repair damaged liver cells buy - large image1

100% China origin factory direct supply Silybin 70% Silybin 80% Silybin 90% Silybin 95% used to protect the liver and repair damaged liver cells buy - image1

100% China origin factory direct supply Silybin 70% Silybin 80% Silybin 90% Silybin 95% used to protect the liver and repair damaged liver cells

Name: 100% China origin factory direct supply Silybin 70% Silybin 80% Silybin 90% Silybin 95% used to protect the liver and repair damaged liver cells
Brand: HANDOM CHEM
SKU: pr2503261374
Price: 0.1 USD
Availability: InStock

TDS 2 Inquiries

Unit Price: Get Latest Price 

CAS No.:

22888-70-6

Grade:

Food Grade

Content:

98%

Port:

Shanghai, Beijing or Shenzhen

Brand:

HANDOM CHEM

Packaging:

50g/Aluminum Foil Bag, 100g/Aluminum Foil Bag, 200g/Aluminum Foil Bag, 500g/Aluminum Foil Bag, 1kg/Aluminum Foil Bag, 5kg/Carton, 10kg/Carton, 20kg/Cardboard Drum or 25kg/Cardboard Drum

Price valid (until):

2025-09-30

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DALIAN HANDOM CHEMICALS CO.,LTD.

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Semaglutide,Tirzepatide,HCG,Retatrutide,Cagrilintide,Medetomidine

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Product Description
Seller Information
Inquiry History

Description

Product Details

Product Name: Silybin (Milk Thistle P.E.)

Extracted From: Silybum marianum (L.) Gaertn.

Plant Background: Milk thistle belongs to the Asteraceae family, native to the Mediterranean, and now distributed worldwide. Its seeds are the source of extraction.

Assay (By HPLC): Silybin 70%, Silybin 80%, Silybin 90%, Silybin 95%, Silybin 98%.

Brief Introduction:

Silybin is a flavonoid lignan compound extracted from milk thistle(Silybum marianum) seeds. It has antioxidant, anti-inflammatory, and hepatocyte protection effects and is commonly used in the treatment of various liver diseases in clinical practice.

The pharmacological effects of Silybin mainly include the following aspects:
It can scavenge free radicals and reduce the damage of oxidative stress to hepatocytes. At the same time, Silybin has anti-inflammatory effects, which can inhibit the release of inflammatory factors and relieve liver inflammation. Silybin can also regulate the metabolism of hepatocytes, promote the regeneration and repair of hepatocytes, and improve liver function.

Shop 100% China origin factory direct supply Silybin 70% Silybin 80% Silybin 90% Silybin 95% used to protect the liver and repair damaged liver cells-Detailed Image 1

Test Items		Specifications (Silybin 70%)
Appearance		Amorphous powder
Colour		Off-white to white
Odour		Slight, Specific
Solubility	In water	Practically insoluble
Solubility	In Methanol and Acetone	Soluble
Identification		A. Passes TLC Test
Identification		B. Passes HPLC Identification Test
Sulphated Ash		Not more than 0.5%
Heavy Metals		Not more than 10 ppm
Lead (Pb)		Not more than 2.0 ppm
Cadmium (Cd)		Not more than 1.0 ppm
Mercury (Hg)		Not more than 0.1 ppm
Arsenic (As)		Not more than 1.0 ppm
Loss on Drying (2 hours, 105℃)		Not more than 5.0%
Particle Size		95% pass through 80 mesh sieve
Assay of Silymarin (UV test, per cent, Standard in House)		Not less than 80%
Assay of Silymarin (Test by HPLC)
-sum of Silycristin and Silydianin
-sum of Silybin A and Silybin B		Not less than 70%
-sum of Isosilybin A and Isosilybin B
Residual Solvents	n-Hexane	Not more than 290 ppm
	Acetone	Not more than 5000 ppm
	Ethanol	Not more than 5000 ppm
	Ethyl Acetate	Not more than 5000 ppm
Pesticide Residues		According to the Standard of USP43<561>
Microbiological Limits	Total Aerobic Microbial Count	Not more than 1000 CFU/g
	Total combined Yeasts & Mould Count	Not more than 100 CFU/g
	Escherichia coli	Negative/g
	Salmonella	Negative/g
	Staphylococcus aureus	Negative/g

Test Items		Specifications (Silybin 80%)
Appearance		Amorphous powder
Colour		Off-white to white
Odour		Slight, Specific
Solubility	In water	Practically insoluble
Solubility	In Methanol and Acetone	Soluble
Identification		A. Passes TLC Test
Identification		B. Passes HPLC Identification Test
Sulphated Ash		Not more than 0.5%
Heavy Metals		Not more than 10 ppm
Lead (Pb)		Not more than 2.0 ppm
Cadmium (Cd)		Not more than 1.0 ppm
Mercury (Hg)		Not more than 0.1 ppm
Arsenic (As)		Not more than 1.0 ppm
Loss on Drying (2 hours, 105℃)		Not more than 5.0%
Particle Size		95% pass through 80 mesh sieve
Assay of Silymarin (UV test, per cent, Standard in House)		Not less than 80%
Assay of Silymarin (Test by HPLC)
-sum of Silycristin and Silydianin
-sum of Silybin A and Silybin B		Not less than 80%
-sum of Isosilybin A and Isosilybin B
Residual Solvents	n-Hexane	Not more than 290 ppm
	Acetone	Not more than 5000 ppm
	Ethanol	Not more than 5000 ppm
	Ethyl Acetate	Not more than 5000 ppm
Pesticide Residues		According to the Standard of USP43<561>
Microbiological Limits	Total Aerobic Microbial Count	Not more than 1000 CFU/g
	Total combined Yeasts & Mould Count	Not more than 100 CFU/g
	Escherichia coli	Negative/g
	Salmonella	Negative/g
	Staphylococcus aureus	Negative/g

Test Items		Specifications (Silybin 90%)
Appearance		Amorphous powder
Colour		Off-white to white
Odour		Slight, Specific
Solubility	In Water	Practically insoluble
Solubility	In Methanol and Acetone	Soluble
Identification		A. Passes TLC Test
Identification		B. Passes HPLC Identification Test
Sulphated Ash		Not more than 0.5%
Heavy Metals		Not more than 10 ppm
Lead (Pb)		Not more than 2.0 ppm
Cadmium (Cd)		Not more than 1.0 ppm
Mercury (Hg)		Not more than 0.1 ppm
Arsenic (As)		Not more than 1.0 ppm
Loss on Drying (2 hours, 105℃)		Not more than 5.0%
Particle Size		95% pass through 80 mesh sieve
Assay of Silymarin (UV test, per cent, Standard in House)		Not less than 80%
Assay of Silymarin (Test by HPLC)
-sum of Silycristin and Silydianin
-sum of Silybin A and Silybin B		Not less than 90%
-sum of Isosilybin A and Isosilybin B
Residual Solvents	n-Hexane	Not more than 290 ppm
	Ethanol	Not more than 5000 ppm
	Ethyl Acetate	Not more than 5000 ppm
Pesticide Residues		According to the Standard of USP43<561>
Microbiological Limits	Total Aerobic Microbial Count	Not more than 1000 CFU/g
	Total combined Yeasts & Mould Count	Not more than 100 CFU/g
	Escherichia coli	Negative/g
	Salmonella	Negative/g
	Staphylococcus aureus	Negative/g

Test Items		Specifications (Silybin 98%)
8Appearance		Amorphous powder
Colour		Off-white to white
Odour		Slight, Specific
Solubility	In Water	Practically insoluble
Solubility	In Methanol and Acetone	Soluble
Identification		A. Passes TLC Test
Identification		B. Passes HPLC Identification Test
Sulphated Ash		Not more than 0.5%
Heavy Metals		Not more than 10 ppm
Lead (Pb)		Not more than 2.0 ppm
Cadmium (Cd)		Not more than 1.0 ppm
Mercury (Hg)		Not more than 0.1 ppm
Arsenic (As)		Not more than 1.0 ppm
Loss on Drying (2 hours, 105℃)		Not more than 5.0%
Particle Size		95% pass through 80 mesh sieve
Assay of Silymarin (UV test, per cent, Standard in House)		Not less than 80%
Assay of Silymarin (Test by HPLC)
-sum of Silycristin and Silydianin
-sum of Silybin A and Silybin B		Not less than 98%
-sum of Isosilybin A and Isosilybin B
Residual Solvents	n-Hexane	Not more than 290 ppm
	Ethanol	Not more than 5000 ppm
	Acetone	Not more than 5000 ppm
Pesticide Residues		According to the Standard of USP43<561>
Microbiological Limits	Total Aerobic Microbial Count	Not more than 1000 CFU/g
	Total combined Yeasts & Mould Count	Not more than 100 CFU/g
	Escherichia coli	Negative/g
	Salmonella	Negative/g
	Staphylococcus aureus	Negative/g

Silybin has the functions and effects of protecting liver, anti-oxidation, anti-inflammation, lowering blood lipids, and improving insulin sensitivity. The details are as follows:

1) Protecting Liver:

Silybin helps protect the liver and repair damaged liver cells by stabilizing liver cell membranes, promoting liver cell regeneration, and inhibiting the binding of liver cell endotoxins. It can be used to prepare silybin capsules for oral administration by patients with liver disease.

2) Antioxidation:

As a powerful antioxidant, silybin can scavenge free radicals and reduce oxidative stress, thereby delaying cell aging and preventing oxidative damage to cells.

3) Anti-inflammatory:

Silybin can inhibit the release of a variety of inflammatory mediators, help reduce inflammatory responses in the body, and reduce tissue damage caused by inflammation.

4) Lowering Blood Lipids:

Silybin helps lower serum cholesterol and low-density lipoprotein levels, thereby helping to improve cardiovascular health.

5) Improving Insulin Sensitivity:

Silybin can increase insulin sensitivity, improve glucose metabolism, and help manage metabolic diseases such as diabetes.

Packaging:

50g/Aluminum Foil Bag, 100g/Aluminum Foil Bag, 200g/Aluminum Foil Bag, 500g/Aluminum Foil Bag, 1kg/Aluminum Foil Bag, 5kg/Carton, 10kg/Carton, 20kg/Cardboard Drum, 25kg/Cardboard Drum or according to the specific requirements from customers.

Shop 100% China origin factory direct supply Silybin 70% Silybin 80% Silybin 90% Silybin 95% used to protect the liver and repair damaged liver cells-Detailed Image 2

Storage Conditions:

Stored in airtight containers in a cool dry place before using; kept away from direct sunlight, heat and moisture.

Shelf Life:

36 months from the date of manufacturing when stored under the above conditions.

Certificates

Basic Info

Product Name:

Silybin

Other Name:

4H-1-Benzopyran-4-one,2-[(2R,3R)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-,(2R,3R)-;4-Chromanone,3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxan-6-yl]-;Silybin;4H-1-Benzopyran-4-one,2-[2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-,[2R-[2α,3β,6(2R*,3R*)]]-;1,4-Benzodioxin,4H-1-benzopyran-4-one deriv.;(2R,3R)-2-[(2R,3R)-2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one;Silybine;Silymarin I;7C3MT;Silliver;Silymarine I;Silibinin;Silymarin MZ 80;Silybum substance E6;Silybin A;Silybin b1;Silibinin A;Mepasil;Realsil;142796-20-1;11054-49-2;11076-05-4;11076-06-5;22888-69-3;27359-03-1;28577-40-4;29832-10-8;37574-50-8;50976-99-3;87725-90-4

CAS No.:

22888-70-6

Molecular Formula:

C25H22O10

InChIKeys:

InChIKey=SEBFKMXJBCUCAI-HKTJVKLFSA-N

Molecular Weight:

482.44

Exact Mass:

482.44

EC Number:

245-302-5

UNII:

33X338MNE4

NSC Number:

651520

DSSTox ID:

DTXSID5023580|DTXSID8026018

ATC Code:

A - Alimentary tract and metabolism

HScode:

2932999099

Categories:

Plant Extracts

Characteristics

PSA:

155

XLogP3:

2.4

Appearance:

solid

Density:

1.5±0.1 g/cm3

Melting Point:

158 °C

Boiling Point:

793°C at 760 mmHg

Flash Point:

274.5±26.4 °C

Refractive Index:

1.684

Water Solubility:

54mg/L(24.99 ºC)

Storage Conditions:

−20°C

Vapor Pressure:

1.63E-26mmHg at 25°C

Toxicity:

LD50 intravenous in mouse: 1056mg/kg

Specific rotation:

D20 +11° (c = 0.25 in acetone + alcohol)

Collision Cross Section:

213.6 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

See More Silybin Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Silybin Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Semaglutide,Tirzepatide,HCG,Retatrutide,Cagrilintide,Medetomidine

Location:
RM702, Building 21, Liuhe Road, Ganjingzi Dist, Dalian, Liaoning, China

Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
15

Total Annual Revenue:
$5 million-$10 million

Total Employees:
51-100

Year of Establishment:
2020

Dalian Handom Chemicals Co., Ltd.(HDC CHEM) is a professional 15-Year-Experienced Supplier of APIs & Intermediates, Pharmaceutical Excipients, Food & Nutraceutical Ingredients, Personal Care Chemicals and Specialty Chemicals from northeast of China, which strives to provide customers with high-quality products and comprehensive service across all over the world, our main products cover Retatrutide Lyophilized Powder, Retatrutide, Tirzepatide, Tirzepatide Lyophilized Powder, Semaglutide, Mazdutide, Cagrilintide, LL-37, Thymosin Alpha 1(Thymosin α1), MT-2, MOTS-c, HEP-1, TB-500, NAD+, GHK-Cu, Glow, Klow, Selank, Semax, Glutathione, 5-Amino-1MQ, ARA-290, SS-31, DSIP, SNAP-8, Medetomidine, Medetomidine Hydrochloride, Salcaprozate Sodium, Sodium 8-(2-hydroxybenzamido)octanoate, 2,6-Dimethyl Beta Cyclodextrin, mPEG-DMG-2K, mPEG-DSPE-2K, 1,2-Distearoyl-sn-3-phosphacholine(DSPC), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE), Pharmaceutical Grade Fructose, Lactose Anhydrous, Lactose Monohydrate, Orotic acid anhydrous, Orotic acid monohydrate, 6-Methyluracil, Chitosan, Mushroom Chitosan, Chitosan Hydrochloride, Chitosan Oligosaccharide, Alginate Oligosaccharide, Inulin, L-Serine, Mung Bean Peptide, Walnut Peptide, Rice Peptide, Oyster Peptide, Sea Cucumber Peptide, Hydrolyzed Keratin, Folic Acid, Vitamin E Acetate, Vitamin B2, Riboflavin Sodium Phosphate, Pyridoxal 5'-phosphate Monohydrate, Vegan Vitamin D3, Vitamin A Palmitate, Vitamin A Acetate, Apple Pectin, Citrus Pectin, Sunflower Pectin, Salidroside, Urolithin A, Milk Thistle Extract, Saffron Extract, Red Clover Extract, Sulforaphane, Glucoraphanin, Soy Isoflavones, Soy Lecithin, Soya Lecithin, Egg Yolk Lecithin, Phosphatidylserine, Cooling Agent WS-3, Cooling Agent WS-5, Cooling Agent WS-10, Cooling Agent WS-12, Cooling Agent WS-23, Cooling Agent WS-27, Menthyl Lactate, Menthyl PCA, Avobenzone, Benzophenone-3 (UV-9), Benzophenone-4 (UV-284), Bis-ethylhexyloxyphenol Methoxyphenyl Triazine (Bemotrizinol), Diethylaminohydroxybenzoyl Hexyl Benzoate (UVA Plus), Diethylhexyl Butamido Triazone (Iscotrizinol), Disodium Phenyl Dibenzimidazole Tetrasulfonate (DPDT), Ethylhexyl Triazone (UVT-150), Homosalate, Octocrylene, 2-Ethylhexyl Salicylate (Octyl Salicylate), 2-Ethylhexyl Trans-4-Methoxycinnamate (OMC), 2-Phenylbenzimidazole-5-Sulfonic Acid (UV-T), Lanolin Anhydrous, Palmitoyl Tripeptide-5, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Biotinoyl Tripeptide-1, etc.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	ISO Certified Reference Material Natural Extract Silibinin Powder CAS 22888-70-6 with 99% Purity	100 G	Oct 11, 2023
India	Milk Thistle Extract 80% UV	1.00 MT	Jun 29, 2026

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