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Calcium Folinate/Leucovorin Calcium API CAS:1492-18-8 | High Purity Pharmaceutical Grade | Vitamin-Active Form buy - large image1

Calcium Folinate/Leucovorin Calcium API CAS:1492-18-8 | High Purity Pharmaceutical Grade | Vitamin-Active Form buy - image1

Calcium Folinate/Leucovorin Calcium API CAS:1492-18-8 | High Purity Pharmaceutical Grade | Vitamin-Active Form buy - image2

Calcium Folinate/Leucovorin Calcium API CAS:1492-18-8 | High Purity Pharmaceutical Grade | Vitamin-Active Form buy - image3

Calcium Folinate/Leucovorin Calcium API CAS:1492-18-8 | High Purity Pharmaceutical Grade | Vitamin-Active Form buy - image4

Calcium Folinate/Leucovorin Calcium API CAS:1492-18-8 | High Purity Pharmaceutical Grade | Vitamin-Active Form

Name: Calcium Folinate/Leucovorin Calcium API CAS:1492-18-8 | High Purity Pharmaceutical Grade | Vitamin-Active Form
Brand: HyperChem
SKU: pr2604161842
Price: 3.5 USD
Availability: InStock

TDS 4 Inquiries

Unit Price:

$3.5-4.5/G FOB

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CAS No.:

1492-18-8

Grade:

Pharmaceutical Grade

Content:

99.9%

Port:

Hangzhou

Brand:

HyperChem

Packaging:

1g/bag, 20g/bag, 50g/bags or other quantities

Price valid (until):

2028-04-30

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Calcium Folinate
CAS number	1492-18-8
Synonym	calcium folinate 1492-18-8 calcio folinato RefChem:1080685 V03AF03
Related APIs #	Leucovorin Levoleucovorin Folinic Acid Pemetrexed Raltitrexed Trimetrexate
Description	Calcium folinate, also known as leucovorin calcium, is a medication that serves a critical role as an adjunct in various therapeutic protocols. It is recognized for its biochemical interaction with specific cellular processes, providing supportive care in medical treatments where cell division and DNA synthesis are key concerns. Description and Characteristics Calcium folinate is a form of folic acid, which is a naturally occurring B vitamin essential for numerous bodily functions, particularly in the synthesis and repair of DNA. Its specific formulation as a calcium salt enhances stability and bioavailability, making it effective for medical use. Unlike folic acid, calcium folinate can bypass certain metabolic blocks, allowing it to be utilized directly by the body in scenarios where folic acid might not be effective. Medical Applications Calcium folinate's versatility is demonstrated through its multiple clinical applications, mainly related to its role as a folate source and its protective properties. Chemotherapy Adjunct: Calcium folinate is commonly used in conjunction with certain chemotherapeutic agents. Some treatments impact rapidly dividing cells, including not only unwanted cells but also normal, healthy ones. Calcium folinate helps protect normal cells from damage, thereby reducing some of the adverse effects associated with chemotherapy. This protective role is especially important in regimens involving drugs that interfere with folate metabolism. Methotrexate Toxicity Management: For individuals receiving high-dose methotrexate—a drug that can block folic acid pathways—calcium folinate acts as a rescue agent. It helps to mitigate the toxic effects of methotrexate on healthy cells by replenishing folate levels and facilitating normal cellular function. Megaloblastic Anemia Support: In cases where anemia is due to folate deficiency, calcium folinate can be administered to help restore normal red blood cell production. Its ability to participate directly in folate-dependent cellular processes makes it effective in correcting specific types of anemia. Mechanism of Action Calcium folinate works by providing a biologically active form of folate that can be utilized directly in critical cellular processes. It supports DNA synthesis, repair, and cell division by supplying necessary cofactors for enzymatic reactions in the folate pathway. This is particularly crucial in tissues where rapid cell turnover occurs, such as the bone marrow and the lining of the gut. When used in combination with chemotherapy, calcium folinate's role involves ‘rescuing’ cells from the effects of folate antagonists. By supplying an active folate form, it protects normal cells from the cytotoxic effects of such drugs, allowing the medication to target abnormal cells more precisely. Source and Development Calcium folinate is synthesized in laboratories to ensure purity and bioavailability. It is developed through chemical processes that convert folic acid into its calcium salt form, maintaining the active configuration necessary for therapeutic efficacy. This synthetic approach ensures consistent quality and dosage, aligning with medical standards and requirements. Safety and Efficacy The safety and efficacy of calcium folinate are well-documented through numerous studies and clinical trials: Supportive Role: Its proven role in reducing treatment-related toxicity highlights its importance in therapeutic protocols, supporting patient outcomes by enhancing tolerability to potent medications. Balancing Efficacy: While offering protection, calcium folinate does not compromise the effectiveness of treatment regimens, maintaining the therapeutic intent of primary medications. Environmental and Ethical Considerations Production of calcium folinate adheres to ethical and environmental standards, focusing on sustainability and quality. Manufacturing processes are designed to reduce environmental impact while ensuring high-quality outputs. Ethical considerations guide clinical use, prioritizing patient safety and well-being. Conclusion Calcium folinate illustrates the synergy between supportive care and primary treatment strategies in medicine. Its ability to safeguard healthy cells while allowing therapeutic agents to function optimally demonstrates its critical role in modern healthcare. As research continues to evolve, calcium folinate remains a cornerstone in protocols requiring balance between efficacy and safety. Its ongoing utilization reflects a broader commitment to developing comprehensive solutions that enhance patient quality of life during intensive treatment regimens, underscoring the essential nature of supportive agents in complex therapeutic landscapes.
Molecular Formula	C ₂₀ H ₂₃ N ₇ O ₇ .Ca C ₂₀ H ₂₃ CaN ₇ O ₇
Molecular Weight	513.5 g/mol
Appearance	White or almost white powder
Quality Standard	Enterprise standard; 99.99%
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0-28℃ for short term (days to weeks) or 0-8 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Double plastic bags inside, fiber drum outside, any quantity available.
Commercial package	Aluminium Tin, Fiber drum
Origin	China

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FAQ

Q1. What is the Hyper chem payment term?
T/T advance
LC at sight
DP at sight
Trade assurance
Money gram

Q2. What is Hyper chem shipment policy?
Our policy is to strive for the quickest shipment time possible, with ready stock sample shipment typically going out the same day that your order was placed. Your satisfaction is very important to us.
For non-ready stock, please contact the Hyper Chem sales team to negotiate.

Q3. What hyper chem will provide after shipment?
For sample orders:
After shipment is done, an timely email including:

Track details (Fedex /TNT/DHL/EMS Track number)

Package photo

COA, MSDS, etc

Dispatch date & Estimated arriving time

Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided
in scan-copy and original, to help customers complete the customs clearance process.

Q4. What is Hyper Chem shipment term?

By Express
DHL  FedEx  TNT  EMS
Fast:5 days around
High cost, door to door service

By Air
Suitable for more than 50kg
Fast :3-7 days Hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Slow:7-45 days, Low cost, port to port, professional broker needed
We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. Does hyper chem provide a shipment return policy?
Yes, we have.
Return Policy: At Hyper chem, your satisfaction is guaranteed. If you are dissatisfied for any reason with a product, please send back the unused portion along with your packing slip and a brief note on why you were dissatisfied within 45 days of purchase for a full refund to:

Q6. What is hyper chem After-sales service
•Documents support: COA ,MSDS, MOA ,MS Report,HNMR Report,SDS,DMF
• Customer Support: Shipment clearance support, quality issue support
• Automated Customer Service: Our worldwide customers enjoy immediate 24/7 access to the HYPER CHEM support team from any location, at any time.

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

Certificates

Basic Info

Product Name:

Calcium folinate

Other Name:

L-Glutamic acid,N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-,calcium salt (1:1);Glutamic acid,N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-,calcium salt (1:1),L-;Calcium L-folinate;Calcium leucovorin;Calcium folinate;Calcium 5-formyltetrahydrofolate;Lederfoline;Leucovorin calcium;Leucovorin calcium salt;Folinic acid calcium salt;Rescuvolin;NSC 3590;Wellcovorin;Folidan;Folinate-SF calcium;6035-86-5;6209-45-6;30771-29-0;1236362-90-5

CAS No.:

1492-18-8

Molecular Formula:

C20H23N7O7.Ca

InChIKeys:

InChIKey=BZPWXVJDMRBCMD-ZEDZUCNESA-N

Molecular Weight:

511.5

Exact Mass:

511.112823

EC Number:

216-082-8

DSSTox ID:

DTXSID3036999|DTXSID3045564|DTXSID20872448

ATC Code:

V - Various

HScode:

2942000000

Categories:

Nutrition Supplements

Characteristics

PSA:

221

Appearance:

powder

Melting Point:

240-250ºC

Water Solubility:

DMSO « 1 (mg/mL)

Specific rotation:

(c = 1, H2O) [a]20 D = 13.0 ± 2º

Collision Cross Section:

198.8 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|202.35 Å² [M-H]- [CCS Type: DT, Method: stepped-field]

See More Calcium folinate Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Skin sensitization, Category 1

Eye irritation, Category 2

Respiratory sensitization, Category 1

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H315 Causes skin irritation H317 May cause an allergic skin reaction H319 Causes serious eye irritation H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P284 [In case of inadequate ventilation] wear respiratory protection. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P333+P317 If skin irritation or rash occurs: Get medical help. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P342+P316 If experiencing respiratory symptoms: Get emergency medical help immediately. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Calcium folinate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

4 Inquiries

Country	Product	Purchase Quantity	Date Posted
Netherlands	Calcium Folinate (Folinic Acid)	1 G	Apr 10, 2025
India	Calcium Folinate	1 KG	Jul 9, 2025
Pakistan	Leucovorin Calcium	500 G	Dec 30, 2024
United States	Folinic acid	1 KG	Apr 21, 2025

Post an enquiry for this product

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