Selank (TP-7) 99% Purity CAS 129954-34-3 Heptapeptide Anxiolytic Nootropic in Stock

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• Core Basic Information:                                             

  • 1、Peptide Structure: A synthetic heptapeptide with the amino acid sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP), derived from a fragment of the human immunoglobulin G heavy chain, with three additional amino acids added to enhance its metabolic stability and duration of action.
  • 2、CAS Number: 129954-34-3; it appears as a white crystalline powder or solid, soluble in water, with a molecular weight of 751.87 and an isoelectric point of 9.83 (predicted).

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  Core Mechanism of Action:                                       

  1.Selank exerts its therapeutic effects through multiple synergistic pathways, primarily targeting the central nervous system (CNS) and immune system:
  GABAergic System Modulation: It enhances the activity of the GABAergic system, the body’s main inhibitory neurotransmitter system, by increasing the affinity of GABA for its receptors, thereby reducing neuronal excitability and exerting a calming, anxiolytic effect.
  2.Neurotransmitter Regulation: It modulates the levels and metabolism of monoamine neurotransmitters such as serotonin and dopamine, which play key roles in mood regulation, cognitive function, and stress response.
  3.Neurotrophic Factor Enhancement: It significantly increases the expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), supporting neuron growth, survival, and repair, and enhancing neural plasticity.
  4.Stress Response Regulation: It acts on the hypothalamus to modulate the secretion of corticotropin-releasing hormone (CRH), regulating the hypothalamic-pituitary-adrenal (HPA) axis and reducing the body’s stress response.
• Key Clinical Uses & Potential Benefits：                  

1、Most Common Adverse Events: Mild-to-moderate gastrointestinal symptoms (nausea, diarrhea, constipation), typically transient and resolving with dose titration
2、Contraindications: History of pancreatitis, severe gastrointestinal disease, or hypersensitivity to the peptide
3、Special Populations: Caution in patients with renal impairment; not recommended during pregnancy/lactation

• Product Specification:                                               
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• Items	Specifications
  Product Name	SELANK
  CAS No.	129954-34-3
  Formula	C33H57N11O9
  EINECS	232-660-2
  Density	1.53±0.1 g/cm3(Predicted)
  Molecular Weight	751.887
  Storage	Cool Dry Place

  
• Company Profile：                                                    
• EnShi Technology Co., Ltd is a modern advanced enterprise specializing in production and exportation of APIs, Pharmaceutical intermediates, plant extracts etc. Our products are widely used in medicine, health care products, cosmetics, nutritional supplements and food additives areas. With years of experience in the pharmaceutical chemical and biosynthetic industries.It provides compliant, stable and cost-effective core raw materials as well as one-stop CDMO/CMO solutions for global pharmaceutical enterprises and innovative drug R&D institutions.