 Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Losartan potassium for Sale > Losartan potassium 124750-99-8

Losartan potassium 124750-99-8 buy - large image1

Losartan potassium 124750-99-8 buy - image1

Losartan potassium 124750-99-8 buy - image2

Losartan potassium 124750-99-8 buy - image3

Losartan potassium 124750-99-8 buy - image4

Losartan potassium 124750-99-8

Name: Losartan potassium 124750-99-8
Brand: Orient
SKU: pr2605201789
Price: 33 USD
Availability: InStock

TDS 9 Inquiries

Unit Price:

$33-34/KG FOB

Get Latest Price 

CAS No.:

124750-99-8

Grade:

Industrail Grade

Content:

99%

Port:

shanghai

Brand:

Orient

Packaging:

1KG, 5KG, 25KG

Price valid (until):

2026-12-31

Contact Supplier

 Chat Now

Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

 Visit Store

Product Description
Seller Information
Inquiry History

Description

Product Name:	Losartan potassium
Synonyms:	2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL;2-butyl-4-chloro-1-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-methanol monopotassium salt;2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOLE-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL, POTASSIUM SALT;LOSARTAN MONOPOTASSIUM SALT;LOSARTAN POTASSIUM;LOSARTAN POTASSIUM SALT;MK 954;1h-imidazole-5-methanol,2-butyl-4-chloro-1-((2’-(1h-tetrazol-5-yl)(1,1’-biphe
CAS:	124750-99-8
MF:	C22H23ClKN6O
MW:	462.01
EINECS:	200-287-4
Product Categories:	API;Cardiovascular APIs;Aromatics;Heterocycles;API Reference Standard;COZAAR;APIS;Hypertension;Intermediates & Fine Chemicals;Pharmaceuticals;Losartan;124750-99-8
Mol File:	124750-99-8.mol

Losartan potassium Chemical Properties

Melting point	263-265°C
storage temp.	Inert atmosphere,Room Temperature
solubility	Freely soluble in water and in methanol, slightly soluble in acetonitrile.
form	powder or crystals
color	Off-white
Water Solubility	H2O: 2mg/mL, clear
Merck	14,5583
BRN	5845770
BCS Class	1
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChI	InChI=1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
InChIKey	OXCMYAYHXIHQOA-UHFFFAOYSA-N
SMILES	C1(C=CC=CC=1C1=CC=C(CN2C(CO)=C(Cl)N=C2CCCC)C=C1)C1=NN=NN1[K]
CAS DataBase Reference	124750-99-8(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/37/39
WGK Germany	3
RTECS	NI6755100
HS Code	2933290000
Storage Class	11 - Combustible Solids

MSDS Information

Losartan potassium Usage And Synthesis

Description	As a angiotensin II receptor antagonist, Losartan Potassium is the potassium salt of losartan with antihypertensive activity, which is mainly used in the therapy of high blood pressure (hypertension) and diabetic nephropathy. It functions by relaxing blood vessels so that blood can flow more easily. It is also effective to help protect the kidneys from damage caused by diabetes and lower the risks of stroke in patients suffering from hypertension and myocardial enlargement. Besides, recent study has suggested that losartan is beneficial to reverse age related dysfunction in maintaining normal blood pressure and cellular energy usage on mitochondria and it can probably be used to treat left ventricular hypertrophy. It may also be used as an alternative agent for the treatment of systolic dysfunction, myocardial infarction, coronary artery disease, and heart failure.
References	https://en.wikipedia.org/wiki/Losartan https://www.drugbank.ca/drugs/DB00678 https://pubchem.ncbi.nlm.nih.gov/compound/11751549#section=Top http://www.medicinenet.com/losartan-oral/article.htm
Description	Angiotensin II is a hormone that plays an important role in regulating blood pressure. Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT₁) receptor. Losartan is an AT₁ receptor antagonist with a K_i value of 5-20 nM. It has an attenuating effect on vein graft atherosclerosis in rabbits and effectively reduces arterial blood pressure in rats. In humans, losartan controls hypertension while protecting renal function.
Description	Losartan potassium is the first potent and selective non-peptide angiotensin II (AT II) AT₁ receptor antagonist introduced to the market as a once-daily oral antihypertensive. It is efficacious and long lasting in controlling blood pressure in spontaneous hypertensive rats, in patients with essential hypertension in addition to those patients with renal impairment. Since losartan functions by competitive antagonism at the level of receptor, which represents the most direct way of selectively inhibiting the renin-angiotensin system (RAS) independent of the source of AT II, its use has been reported to be free of the coughing side effect exhibited by the ACE inhibitors. In contrast to calcium channel blockers, losartan does not appear to cause ankle edema, headache and tachycardia. It is also reported to be in clinical trials for the treatment of heart failure. Other reports indicate that losartan may have potential efficacy as an anxiolytic, an antiglaucoma agent, in addition to in providing protection against stroke and in preventing the myointimal proliferative response of the vascular wall after coronary angioplasty and surgery.
Chemical Properties	White to Off-White Crystalline Powder
Originator	DuPont Merck (U.S.A.)
Uses	A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.
Uses	antihypertensive, AT1 angiotensin II antagonist
Uses	Coronary vasodilator used in the diagnosis of coronary heart disease (adenosine A2A agonist).
Manufacturing Process	2-Butyl-4-chloro-1-(2'-(tetrazol-5-yl)biphenyl-4-ylmethyl)-1H-imidazole-5- methanolpotassium was synthesized in 5 stages. 1. Methyl 4'-methylbiphenyl-2-carboxylate (44.2 mmol), 0.5 N KOH in methanol (133 mmol), and water (50 mL) were mixed and refluxed under nitrogen. After 5 hours, the solvent was removed in vacuo and water (200 mL) and ethyl acetate (200 mL) added. The aqueous layer was acidified with concentrated hydrochloric acid to a pH of 3 and the layers were separated. The aqueous phase was extracted with ethyl acetate, the organic layers collected, dried (MgSO4) and the solvent removed in vacuo to yield 8.71 g of a 4'-methylbiphenyl-2-carboxylic acid, melting point 140.0-145.0°C. 2. 4'-Methylbiphenyl-2-carboxylic acid (41 mmol) and thionyl chloride (411 mmol) were mixed and refluxed for 2 hours. The excess thionyl chloride was removed in vacuo and the residue was taken up in toluene. The toluene was removed by rotary evaporation. The crude acid chloride was then added slowly to cold (0°C) concentrated NH4OH (50 mL) so that the temperature was kept below 15°C. After 15 minutes of stirring, water (100 mL) was added and solids precipitated. These were collected, washed with water and dried under high vacuum over P2O5 to yield 7.45 g of a white solid, melting point 126.0-128.5°C. The above product amide (35 mmol) and thionyl chloride (353 mmol) were mixed and refluxed for 3 hours. The thionyl chloride was removed using the same procedure as described above. The residue was washed with a little hexane to yield 6.64 g of 4'-methyl-2-cyanobiphenyl, melting point 44.0- 47.0°C.

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

Firefighting measures

Extinguishing media

Use dry chemical, carbon dioxide or alcohol-resistant foam.

Specific Hazards Arising from the Chemical

no data available

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

Shop Orthophosphorus acid 10294-56-1-Detailed Image 1

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 2

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 3

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 4

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 5

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 6

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 7

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 8

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 9

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 10

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 11

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 12

—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

Losartan potassium

Other Name:

1H-Imidazole-5-methanol,2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-,potassium salt (1:1);1H-Imidazole-5-methanol,2-butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-,monopotassium salt;DuP 753;Du Pont 753;MK 954;Losartan potassium;Cozaar;Nu-Lotan;Losartan monopotassium salt;Zaart;Losacar;Losium;Aradois;Losartan potassium salt;Losar;Presartan 50;Losata;Tancin;Amosar;Losatan potassium;Potassium 5-(4′-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-yl)tetrazol-1-ide;405554-24-7;1017795-20-8;1202865-13-1;1262770-26-2

CAS No.:

124750-99-8

Molecular Formula:

C22H23ClN6O.K

InChIKeys:

InChIKey=FDKIDFYIEWFERB-UHFFFAOYSA-N

Molecular Weight:

462.01

Exact Mass:

460.118068

EC Number:

200-287-4

UNII:

3ST302B24A

DSSTox ID:

DTXSID3044209

NCI Thesaurus Code:

C29165

ATC Code:

B - Blood and blood forming organs

HScode:

2933290000

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

77.7

XLogP3:

3.89590

Appearance:

white to off-white crystalline powder

Density:

0.986 g/mL at 25 °C(lit.)

Melting Point:

183.5-184.5 °C

Boiling Point:

682°C at 760 mmHg

Flash Point:

366.3ºC

Refractive Index:

n20/D 1.387(lit.)

Water Solubility:

Freely soluble in water and in methanol, slightly soluble in acetonitrile.

Storage Conditions:

Desiccate at RT

Vapor Pressure:

1.55E-19mmHg at 25°C

See More Losartan potassium Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Losartan potassium Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

9 Inquiries

Country	Product	Purchase Quantity	Date Posted
Sri Lanka	Losartan Potassium BP 2024 / BP 2025	6000 KG	Jun 19, 2026
India	Losartan potassium	1 MT	Jun 27, 2024
Bangladesh	Losartan Potassium BP	1800.00 KG	Nov 11, 2023
India	Losartan Potassium	5 MT	Sep 4, 2025
India	Losartan Potassium	10 MT	Aug 29, 2025
Pakistan	LOSARTAN POTASSIUM	50 KG	Mar 18, 2024
Bulgaria	losartan potassium	50 G	May 20, 2026
Bangladesh	Losartan potassium	1500.00 KG	Dec 11, 2025
India	Losartan Potassium	2.00 MT	Mar 31, 2025

Post an enquiry for this product

More Choices Find All Products for Sale 

Product Name	Grade / Content	Supplier Name	Details
Losartan potassium	/99	Creative Enzymes	Inquiry
Synergene Losartan Potassium	/	Synergene	Inquiry
Losartan potassium124750-99-8	/	Shandong zhishang chemical Co.,Ltd	Inquiry
Losartan potassium	/	Hangzhou Dawn Ray Pharmaceutical Co.,Ltd	Inquiry
High Quality GMP/CEP/WC USP Standard API White Powder Losartan potassium CAS 124750-99-8	Pharmaceutical Grade/99	Hangzhou Hyper Chemicals Limited	Inquiry