Losartan potassium

The main ingredient of this product is losartan potassium. Chemical name: 2-butyl-4-chloro-1-[[2'-(1H-tetrazolyl-5-yl)[1,1prime;-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol monopotassium salt Molecular weight: C22H22ClKN6O

In clinical pharmacokinetic studies, it has been confirmed that there are no clinically significant drug interactions with hydrochlorothiazide, digoxin, warfarin, cimetidine, phenobarbital, ketoconazole and erythromycin. Rifampicin and fluconazole have been reported to reduce the levels of active metabolites. The clinical consequences of these interactions have not been evaluated. 1. Like other drugs that inhibit angiotensin II and its effects, this product can cause increased serum potassium when used in combination with potassium-sparing diuretics (such as spironolactone, triamterene, amiloride), potassium supplements, or potassium-containing salt substitutes. 2. Like other drugs that affect sodium excretion, lithium excretion may be reduced. Therefore, if lithium salts are used in combination with angiotensin II receptor antagonists, serum lithium levels should be carefully monitored. 3. Nonsteroidal anti-inflammatory drugs (NSAIDs) include

This product is a compound preparation, and its components are: each tablet contains 50 mg of losartan potassium and 12.5 mg of hydrochlorothiazide.

In clinical pharmacokinetic studies, no clinically significant drug interactions were found with hydrochlorothiazide, digoxin, warfarin, cimetidine, phenobarbital (see Hydrochlorothiazide: Alcohol, Barbiturates or Narcotics below), ketoconazole, and erythromycin. Rifampicin and fluconazole have been reported to reduce the levels of the active metabolite. The clinical significance of these interactions has not been evaluated. As with other drugs that block angiotensin II and its effects, coadministration of losartan potassium with potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, or potassium-containing salt substitutes may result in elevated serum potassium. Nonsteroidal anti-inflammatory drugs (NSAIDs), including selective cyclooxygenase-2 inhibitors (COX-2 inhibitors), may reduce the effect of diuretics or other antihypertensive drugs. Therefore, the effects of angiotensin II receptor antagonists may also be attenuated by NSAIDs, including selective COX-2 inhibitors. In some patients with renal impairment who are taking nonsteroidal anti-inflammatory drugs, including selective COX-2 inhibitors, the concomitant use of angiotensin II receptor antagonists may lead to further deterioration of renal function and possible acute renal failure, an effect that is usually reversible. The following drugs may interact with thiazide diuretics when hydrochlorothiazide is taken concomitantly: Alcohol, barbiturates, or anesthetics - may precipitate orthostatic hypotension. Antidiabetic agents (oral agents and insulin) - dose adjustment of antidiabetic agents may be required. Other antihypertensive agents - additive effects. Cholestyramine and colestipol resins - the presence of anion exchange resins impairs the absorption of hydrochlorothiazide. Single doses of cholestyramine or colestipol resin bind to hydrochlorothiazide and reduce the absorption of thiazides from the gastrointestinal tract by up to 85% and 43%, respectively. Corticosteroids, ACTH - exacerbate electrolyte losses, particularly leading to hypokalemia. Vasopressors (e.g., epinephrine) - may reduce the response to vasopressors, but not enough to preclude their use. Skeletal muscle relaxants, non-depolarizing (e.g., tubocurarine) - May enhance the response to muscle relaxants. Lithium - Diuretics reduce the renal clearance of lithium, greatly increasing the risk of lithium toxicity, and concomitant use is not recommended. Consult the instructions for lithium preparations before use. Nonsteroidal anti-inflammatory drugs, including selective COX-2 inhibitors - The use of nonsteroidal anti-inflammatory drugs, including selective COX-2 inhibitors, in some patients may reduce the diuretic, natriuretic, and antihypertensive effects of diuretics. Drug/Laboratory Test Interactions Due to their effects on calcium metabolism, thiazides may interfere with parathyroid function tests (see PRECAUTIONS).