Avanafil CAS 330784-47-9 High Purity Raw Material Supplier
TDS 10 Inquiries
330784-47-9
USP / EP / BP / JP Grade
99%
hk
rongchuang
Customizable
Yes
2026-06-21
Pharmaceutical APIs / Intermediates,Research Peptides,Cognitive Enhancers,Organic Chemicals,Chemical Raw Materials,GHK-CU
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Product Details
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceAvanafil(TA-1790) is a potent and highly selective phosphodiesterase-5(PDE-5) inhibitor(IC50=5.2 nM) for erectile dysfunction; lower selectivity against PDE1, PDE6, and PDE11.IC50 value: 5.2 nM [1]Target: PDE5Avanafil is highly selective toward PDE5 and against all other PDE isozymes tested. Lower selectivity against PDE1, PDE6, and PDE11 is consistent with results from randomized, placebo-controlled, phase 3 trials in which musculoskeletal and hemodynamic adverse events were reported in
Avanafil is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4-[(3-chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid with the amino group of pyrimidin-2-ylmethylamine. Used for treatment of erectile dysfunction. It has a role as an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor and a vasodilator agent. It is a member of pyrimidines, an aromatic amide, an organochlorine compound, a member of prolinols and a monocarboxylic acid amide.|Avanafil is a new phosphodiesterase-5 inhibitor that is faster acting and more selective than other drugs belonging to the same class. Chemically, it is a derivative of pyrimidine and is only available as the S-enantiomer. FDA approved on April 27, 2012.|Avanafil is a Phosphodiesterase 5 Inhibitor. The mechanism of action of avanafil is as a Phosphodiesterase 5 Inhibitor.|Avanafil is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction. Avanafil is a relatively new medication and has yet to be linked to instances of serum enzyme elevations or with clinically apparent acute liver injury.|Avanafil is an orally available phosphodiesterase type 5 (PDE5) inhibitor with vasodilatory activity. Avanafil selectively inhibits PDE5, thus inhibiting the degradation of cyclic guanosine monophosphate (cGMP) found in the smooth muscle of the corpus cavernosa of the penis. The inhibition of cGMP degradation results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, thereby prolonging penile erection.CertificatesBasic Info-
Product Name:
Avanafil
Other Name:5-Pyrimidinecarboxamide,4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-;4-[[(3-Chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide;(S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[N-(2-pyrimidinylmethyl)carbamoyl]pyrimidine;TA 1790;Avanafil;(S)-4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide;Spedra;330785-17-6;647841-09-6
CAS No.:330784-47-9
Molecular Formula:C23H26ClN7O3
InChIKeys:InChIKey=WEAJZXNPAWBCOA-INIZCTEOSA-N
Molecular Weight:483.95
Exact Mass:483.95
UNII:DR5S136IVO
DSSTox ID:DTXSID50186727
NCI Thesaurus Code:C74354
ATC Code:G04BE10|G - Genito urinary system and sex hormones
HScode:2933990090
Categories:
Characteristics-
PSA:
125
XLogP3:2.6
Appearance:White solid
Density:1.4±0.1 g/cm3
Melting Point:150-152°C
Refractive Index:1.651
Storage Conditions:Refrigerator
Hazard IdentificationClassification of the substance or mixture
Skin irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Warning
Hazard statement(s) H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceutical APIs / Intermediates,Research Peptides,Cognitive Enhancers,Organic Chemicals,Chemical Raw Materials,GHK-CU
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Location:
Room 505, Building 5, Dongfang Rongcheng Garden, No. 899 Chisong Road, Chisong Town, Jindong District, Jinhua City, Zhejiang Province
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
15 days
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
5-10
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Year of Establishment:
2026
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Inquiry History10 Inquiries
Country Product Purchase Quantity Date Posted
Pakistan
avanafil
14 MT May 19, 2026
Malaysia
Avanafil CAS No:330784-47-9 Dapoxetine Hydrochloride (CAS Number: 129938-20-1)
100 KG Apr 26, 2026
United States
avanafil
10 G Apr 11, 2026
United States
Avanafil
1 MT Sep 20, 2025
India
Avanafil
25 KG Aug 15, 2025
Jordan
Avanafil powder
1 KG Jun 18, 2025
United States
Avanafil Usp Powder 99% white Crystaline Powder
10 G Feb 19, 2025
United States
Avanafil Usp Powder 99% white Crystaline Powder
1 KG Feb 17, 2025
Pakistan
Avanafil
1 KG Sep 16, 2024
France
Avanafil
1 KG Aug 5, 2024 Post an enquiry for this product
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