High Purity Calcium Beta-Hydroxy-Beta-Methylbutyrate Pharmaceutical Grade Research Grade Powder CAS 135236-72-5

Calcium beta-hydroxy-beta-methylbutyrate More Info

Calcium beta-hydroxy-beta-methylbutyrate, commonly abbreviated as HMB-Ca or CaHMB, is the calcium salt form of HMB acid. With the molecular formula C₁₀H₁₈CaO₆ and a molecular weight of approximately 274.32 g/mol, this compound appears as a white, water-soluble crystalline powder. Chemically known as calcium bis(3-hydroxy-3-methyl) salt, HMB-Ca is a metabolite naturally present in foods such as avocado, citrus fruits, cauliflower, alfalfa, and some fish species.

HMB-Ca serves as a bioactive metabolite derived from the essential amino acid leucine. In human metabolism, approximately 5-10% of dietary leucine is converted into HMB through a two-step pathway: first, leucine undergoes transamination to alpha-ketoisocaproate (KIC), which is then metabolized to HMB by the enzyme KIC-dioxygenase. Leucine plays an important role in protein metabolism, and HMB functions as a key intermediate associated with leucine's effects on muscle protein balance. Unlike free leucine, which is primarily directed toward energy production or protein synthesis, HMB specifically interacts with muscle tissue protein dynamics.

The functional properties of HMB-Ca involve modulation of cellular protein turnover processes. By influencing proteolytic pathways, HMB supports reduced muscle protein breakdown while simultaneously enhancing protein synthesis, creating a net environment favoring lean body mass maintenance. This dual action distinguishes HMB from many other nutritional supplements that primarily focus only on protein synthesis. Additionally, HMB has been observed to interact with lipid metabolism processes, with documented effects on total cholesterol and LDL cholesterol levels.

In the field of sports nutrition and dietary supplementation, HMB-Ca has been extensively studied for applications supporting lean body mass across various populations. It is widely recognized for its role in maintaining muscle mass during aging, supporting physical recovery, and enhancing exercise performance in active individuals. Regulatory bodies worldwide have established a recommended maximum daily intake of 6 grams of CaHMB for adults, with individual servings limited to 1.5 grams in formulated products. The compound has received Generally Recognized as Safe (GRAS) status from the U.S. FDA and has been approved as a novel food ingredient for use in meal replacements, formulated liquid diets, sports nutrition products, and specialty nutrition applications.

The safety profile of HMB-Ca has been evaluated through comprehensive assessments following international guidelines. These evaluations have included oral exposure studies, genetic safety studies, developmental studies, and human clinical trials, all of which support the safe use of the compound at recommended intake levels. Standard handling precautions including protective gloves, eye protection, and adequate ventilation are recommended when handling bulk powder. Materials supplied are intended for use as a raw material ingredient in finished product formulations.

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Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

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