Dihydrohonokiol (DHH-B), 99% HPLC, Pharmaceutical Grade Raw Material, CAS 219565-74-9

Dihydrohonokiol-B More Info

Dihydrohonokiol-B, commonly abbreviated as DHH-B, is a bioactive neolignan compound derived from the bark of Magnolia species, particularly Magnolia officinalis. It is a reduced derivative of honokiol, a well-known constituent with a long history of use in traditional Chinese and Japanese medicine . Chemically, DHH-B is identified as [1,1'-]-2,4'-diol, 3'-(2-propen-1-yl)-5-propyl- and is also referred to by the synonym dihydrohonokiol . Its structure features a  core with propyl and propenyl substitutions, and it has the molecular formula C₁₈H₂₀O₂ with a molecular weight of approximately 268.35 g/mol .

The primary mechanism of action for Dihydrohonokiol-B involves its potent interaction with the GABAergic system, specifically as an agonist of the GABAᵪ (GABA-C) receptor . By stimulating this receptor, DHH-B enhances the calming effects of the neurotransmitter GABA, which helps soothe neural activity that can lead to agitation and anxiety . This mechanism is also responsible for its significant anxiolytic (anti-anxiety) properties, which have been a major focus of research. Furthermore, studies indicate that DHH-B can reduce the neurotoxicity induced by amyloid-β protein, suggesting a potential application in research on neurodegenerative conditions such as Alzheimer's disease .

Beyond its effects on the central nervous system, Dihydrohonokiol-B exhibits a multifaceted pharmacological profile that includes anti-inflammatory and antioxidant activities. Research suggests that DHH-B can activate cannabinoid receptors throughout the body, which play a role in modulating the immune system and pain relief, leading to reduced inflammation . Additionally, its antioxidant properties help decrease oxidative stress in the brain, offering a neuroprotective effect. DHH-B has also been researched for its ability to function as a sleep promoter, as its calming effects on the mind and body can increase time spent in REM sleep and reduce the time it takes to fall asleep .

From a physicochemical and handling perspective, Dihydrohonokiol-B is typically supplied as a white to off-white solid powder . For optimal stability and long-term storage, the powder should be kept at -20°C, where it remains stable for up to three years, or at 4°C for up to two years. Once dissolved in a solvent, it is recommended to store the solution at -80°C for up to six months . Suppliers indicate that DHH-B is soluble in organic solvents, and its purity is often verified through analytical methods such as High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Spectrometry (LCMS), with reported purity levels exceeding 99% .

The safety profile for research-grade Dihydrohonokiol-B is well-documented by suppliers. It is strictly intended for laboratory research use only and is explicitly not for human or veterinary therapeutic applications . While some safety data sheets classify it as a non-hazardous substance, others note specific hazards. For example, one source classifies DHH-B with GHS hazard statements H318 (causes serious eye damage) and H411 (toxic to aquatic life with long-lasting effects) . Consequently, standard laboratory precautions should be taken, which include using personal protective equipment such as safety goggles and gloves, ensuring adequate ventilation, and washing thoroughly after handling . It should also be kept away from drains and water courses to prevent environmental contamination .

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