Spermidine HCL

Spermidine trihydrochloride is a stable form of spermidine, which is a white water-soluble powder with activities such as activating cell autophagy, antioxidant and anti-inflammatory. It can efficiently eliminate free radicals, promote the degradation of damaged organelles and cell renewal, and reduce inflammation; At the same time, it can maintain scalp health, prolong hair follicle growth period, and is also commonly used in the fields of nutrition, health care, and scientific research. It has high safety and wide adaptability, and is the preferred active ingredient for anti-aging and repair formulas.

Product Name: Spermidine Trihydrochloride

Appearance: White to off-white powder

CAS No.: 334-50-9

Formula: C7H19N3·3HCl

Formula Weight: 254.63 

Purity: >98%

Package size: 25kg/drum

Spermidine trihydrochloride can penetrate cells and act on autophagy related pathways, inducing cells to initiate autophagy programs, degrade and eliminate aging damaged cells and metabolic waste; Simultaneously clearing excess free radicals in the body, inhibiting the release of inflammatory factors, reducing oxidative stress and inflammatory damage, thereby slowing down the process of cellular aging, stabilizing cellular physiological activity, and achieving anti-aging and repair effects.

There are three mian manufacture process for spermidine trihydrochloride :

natural extraction, chemical synthesis, and microbial fermentation.

1) Natural extraction, mainly extracted from wheat germ. The extracted spermidine is safe and mild, but has low content, high extraction cost, and low purity, generally around 1% purity.  

2) Chemical synthesis (mainstream source), the raw materials are synthesized through multiple steps of reaction, then salted with hydrochloric acid and purified by recrystallization. The synthetic process of spermidine has high purity (greater than or equal to 98%), low cost, scalable production, stable quality, and stable delivery time.

3) Microbial fermentation, produced by engineering bacteria such as Escherichia coli, synthesizes spermidine and then forms salt. The fermentation process is currently not very mature and cannot be mass-produced.

Common foods containing spermidine include cereals such as wheat germ, brown rice, oats and corn, legumes and nuts such as soybeans, black beans, peanuts and walnuts, mushrooms such as shiitake mushrooms, pleurotus ostreatus and agaric, fermented foods such as cheese, Fermented bean curd, natto and pickles, meat and aquatic products such as animal liver, shellfish, fish and shrimp, but the spermidine content in foods is extremely low.

Anti aging application: can be combined with astaxanthin ,Urolithin a, EGCG、 Resveratrol , Pterostilbene.etc.

Hair Health: Can be paired with saw palm extract to stabilize hair follicles and prolong hair growth period .

Spermidine hydrochloride has a high overall safety profile and is well tolerated by the human body under normal dietary and routine supplementation doses, with very few significant adverse reactions occurring; A small number of people may experience mild gastrointestinal discomfort, such as bloating, diarrhea, nausea, and stomach pain, which often occur during the initial use or when the dosage is too high. Reducing the dosage and taking it with meals can alleviate the discomfort.

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